{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:14:15Z","timestamp":1764494055202,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy of neuroendocrine origin presenting as a painless, rapidly growing nodule. MCC often presents in elderly, fair-skinned individuals in sun-exposed areas. Diagnosis is often overlooked at time of presentation due to its rarity, but MCC is twice as deadly as malignant melanoma. There has been bigger interest in the disease due to increasing incidence and an association with the prevalent virus Merkel cell polyomavirus. This study describes an uncommon presentation of MCC as a right gluteal lesion in an Afro-Panamanian patient. The tumor was suspected to be fibrolipoma, but Immunohistochemistry revealed the diagnosis of MCC, as stains for CD56 and CK20 were positive. In addition to surgical excision, the patient was referred for adjuvant radiotherapy. This case report and literature review elucidates the clinical, histopathologic and management aspects of MCC, which will help in recognizing and treating these tumors.<\/jats:p>","DOI":"10.1093\/jscr\/rjz322","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T04:10:36Z","timestamp":1570507836000},"source":"Crossref","is-referenced-by-count":7,"title":["Merkel cell carcinoma: a case report and literature review"],"prefix":"10.1093","volume":"2019","author":[{"given":"Nicholas","family":"Mulchan","sequence":"first","affiliation":[{"name":"St George\u2019s University School of Medicine, True Blue, Grenada, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cayton","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Brooklyn Hospital Center, Icahn School of Medicine at Mount Sinai, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armand","family":"Asarian","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Brooklyn Hospital Center, Icahn School of Medicine at Mount Sinai, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Brooklyn Hospital Center, Icahn School of Medicine at Mount Sinai, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2019122310301596000_ref1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fonc.2018.00048","article-title":"Merkel cell carcinoma: An update and immunotherapy","volume":"8","author":"","year":"2018","journal-title":"Front Oncol"},{"key":"2019122310301596000_ref2","first-page":"1","article-title":"Burden of disease, early 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system","volume":"23","author":"Harms","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"2019122310301596000_ref6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jaad.2007.11.020","article-title":"Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: The AEIOU features","volume":"58","author":"Heath","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2019122310301596000_ref7","doi-asserted-by":"crossref","DOI":"10.1111\/dth.12749","article-title":"Recurrent Merkel cell carcinoma of the gluteal region: A case report","volume":"32","author":"Turkkan","year":"2019","journal-title":"Dermatol Ther"},{"key":"2019122310301596000_ref8","first-page":"849767","article-title":"Giant merkel cell carcinoma masquerading as a benign cyst on the buttock of an african american man","volume":"2011","author":"Perman","year":"2011","journal-title":"Case Rep Oncol Med"},{"key":"2019122310301596000_ref9","first-page":"rjy185","article-title":"An unusual presentation of Merkel cell carcinoma: A case report","volume":"8","author":"Howell","year":"2018","journal-title":"J Surg Case Rep"},{"key":"2019122310301596000_ref10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40425-017-0310-x","article-title":"Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after \u22651 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial","volume":"6","author":"Kaufman","year":"2018","journal-title":"J Immunother Cancer"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2019\/11\/rjz322\/31062571\/rjz322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2019\/11\/rjz322\/31062571\/rjz322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T10:32:46Z","timestamp":1577097166000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjz322\/5634098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjz322","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,11,1]]},"article-number":"rjz322"}}