{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:56:03Z","timestamp":1753876563139,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant melanoma is an aggressive neural crest cell-derived neoplasm with a propensity for metastasis to almost any organ. Gastrointestinal metastasis may manifest as gallbladder polyps. We report a case of metastatic malignant melanoma diagnosed in an 81-year-old male after cholecystectomy performed for acute cholecystitis. Cholecystectomy remains the standard of care for treatment of isolated gallbladder metastasis, especially in the setting of symptomatic disease. Mutation-directed chemotherapeutic and immunotherapeutic modalities serve as efficacious adjunctive therapy in addition to primary surgical resection for this rare condition.<\/jats:p>","DOI":"10.1093\/jscr\/rjz324","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T03:22:28Z","timestamp":1570159348000},"source":"Crossref","is-referenced-by-count":6,"title":["Metastatic melanoma of the gallbladder presenting as polyp in acute cholecystitis"],"prefix":"10.1093","volume":"2019","author":[{"given":"Nirvana B","family":"Saraswat","sequence":"first","affiliation":[{"name":"Department of Surgery, Riverside Methodist Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William B","family":"DeVoe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Riverside Methodist Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"volume-title":"Cutaneous Melanoma: Etiology and Therapy","year":"2017","author":"Matthews","key":"2019121107071245800_ref1"},{"key":"2019121107071245800_ref2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"2019121107071245800_ref3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ijc.27616","article-title":"International trends in the incidence of malignant melanoma 1953-2008--are recent generations at higher or lower risk","volume":"132","author":"Erdmann","year":"2013","journal-title":"Int J Cancer"},{"key":"2019121107071245800_ref4","first-page":"23","article-title":"\u00dcber die physiologische und pathologische Melaninpigmentierung und den epithelialen Ursprung der Melanoblastome. Ein prim\u00e4res Melanoblastom der Gallenblase","volume":"42","author":"Wieting","year":"1907","journal-title":"Beitr Path Anat"},{"key":"2019121107071245800_ref5","article-title":"Primary malignant melanoma of the gallbladder with multiple metastases: a case report","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine"},{"key":"2019121107071245800_ref6","first-page":"68","article-title":"Metastatic malignant melanoma to the gallbladder. 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