{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:58:06Z","timestamp":1787237886059,"version":"build-2736575974"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Necrotising soft tissue infection (NSTI) is a rare yet life-threatening surgical emergency, characterized by rapidly spreading infection below the epidermis to the soft tissue layers of the dermis, subcutaneous layers, fascia and sometimes muscle. Multi-focal NSTIs have been rarely described in the literature, with reported cases predominantly involving immunocompromised patients. We report a case of an immunocompromised 70-year-old woman who initially presented with concern of a perforated colonic malignancy requiring exploratory laparotomy and within 24\u00a0hours while on inotropes, developed rapidly progressing necrotizing fasciitis (NF) of the left thigh with renal failure secondary to sepsis. Despite aggressive debridement, a progress computed tomography later showed multi-focal non-contiguous necrotising myositis of the whole left lower limb and right gluteal regions. Early diagnosis of multi-focal NF especially in immunocompromised patients, repeat assessment, aggressive surgical debridement and prompt antibiotics usage are the key to treatment.<\/jats:p>","DOI":"10.1093\/jscr\/rjz338","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T15:27:01Z","timestamp":1571066821000},"source":"Crossref","is-referenced-by-count":5,"title":["A rare case of multi-focal non-contiguous necrotizing soft tissue infections and literature review"],"prefix":"10.1093","volume":"2019","author":[{"given":"Yaying Eileen","family":"Xu","sequence":"first","affiliation":[{"name":"General Surgical Department, Caboolture Hospital, Brisbane 4510, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Gounder","sequence":"additional","affiliation":[{"name":"General Surgical Department, Caboolture Hospital, Brisbane 4510, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2019112008302115100_ref1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2478\/v10039-010-0002-y","article-title":"Multifocal necrotizing fasciitis - case report","volume":"55","author":"Musialkowska","year":"2010","journal-title":"Adv Med Sci"},{"key":"2019112008302115100_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12245-018-0183-x","article-title":"Necrotising fasciitis: a fatal case of sepsis and a diagnostic challenge \u2013 case report and review of literature","volume":"11","author":"Agarwal","year":"2018","journal-title":"Int J Emerg Med"},{"key":"2019112008302115100_ref3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/crsi.2017.0014","article-title":"Fatal multi-focal necrotizing soft tissue infection in an Immunocompromised patient","volume":"2","author":"Sheka","year":"2017","journal-title":"Surg Infect Case Reports"},{"key":"2019112008302115100_ref4","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.jemermed.2013.05.064","article-title":"\u2018Synchronous\u2019 multifocal necrotizing fasciitis","volume":"45","author":"Tocco","year":"2013","journal-title":"J Emerg Med"},{"key":"2019112008302115100_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bcr-2014-207089","article-title":"Multifocal necrotising fasciitis: a rarer presentation of a rare disease","volume":"2014","author":"Herrod","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2019112008302115100_ref6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bjps.2011.09.001","article-title":"Multifocal necrotising fasciitis: an overlooked entity?","volume":"65","author":"El-Khani","year":"2012","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2019112008302115100_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-019-4103-3","article-title":"Risk factors of synchronous multifocal necrotizing fasciitis: a case control study in comparison with monofocal necrotizing fasciitis in Taiwan","volume":"19","author":"Lee","year":"2019","journal-title":"BMC Infect Dis"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2019\/11\/rjz338\/31062642\/rjz338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2019\/11\/rjz338\/31062642\/rjz338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T08:30:36Z","timestamp":1574238636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjz338\/5634109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":7,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjz338","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,11,1]]},"article-number":"rjz338"}}