{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:08:09Z","timestamp":1790118489435,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collagenase Clostridium histolyticum (CCH) has been proven effective in multiple subpopulations of PD men; however, no studies have evaluated its role with congenital penile curvature (CPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the safety and efficacy of CCH in men with CPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective registry was queried of men undergoing CCH injections at our institution. Beginning in 2016, CCH was administered to CPC men using a similar protocol to PD. A comparative analysis was performed between cohorts to evaluate the safety and efficacy of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Objective measures included penile length and curvature, while subjective outcomes included standardized (International Index of Erectile Function and Peyronie\u2019s Disease Questionnaire) and non-standardized assessments. Curvature outcomes were categorized as follows: 1 \u2013 included all men, with the most recent assessment considered final, and 2 \u2013 only men who had completed eight CCH injections or stopped early due to satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2014 to Oct 2021, a total of 453 men (408 PD, 45 CPC) underwent one or more CCH injections. In comparing cohorts, CPC men were younger (33 vs 58 years, p&amp;lt;0.0001), had lesser baseline curvatures (52.5 vs 65\u00b0, p&amp;lt;0.01), more ventral curves (25.7 vs 9.2%, p&amp;lt;0.01), and longer penile lengths (12.5 vs 12.0 cm, p=0.04). Following treatment, both cohorts experienced similar curvature improvements. Specifically, PD men experienced 20-25\u00b0 or 33-35% improvements depending on definition compared to 25-30\u00b0 or 40-50% in CPC men (all p-values &amp;gt;0.05). CPC and PD men also demonstrated similar changes on standardized questionnaires, with the exception of the Psychological and Physical subdomain, which was more improved in CPC men (-11 vs -4, p&amp;lt;0.01). Baseline curvature was positively correlated with greater absolute (degree) and relative (percent) improvements. Adverse events were similar between groups after controlling for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>CCH may be safely and effectively administered in men with CPC. These data provide the first evidence for the efficacy of a non-surgical therapeutic option in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths and Limitations<\/jats:title><jats:p>Strengths \u2013 large, prospective series with standardized assessments; Limitations - non-randomized study, short-term follow-up, and lack of standardized method to differentiate CPC from PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CCH may be safely and effectively administered to men with CPC, with similar success rates compared to PD. Increasing curvature was associated with greater absolute (degree) and relative (percent) improvements, supporting the role for CCH in men with mild, moderate, or severe curvatures. External validation is warranted prior to routine implementation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jsxmed\/qdac006","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T09:06:08Z","timestamp":1673514368000},"page":"194-199","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of collagenase<i>Clostridium histolyticum<\/i>in men with congenital penile curvature"],"prefix":"10.1093","volume":"20","author":[{"given":"Yogesh","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Hampton University School of Pharmacy , Hampton, VA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Green","sequence":"additional","affiliation":[{"name":"CURE PD , Orem, UT , United States"},{"name":"Brigham Young University , Provo, UT , United States"},{"name":"Male Fertility and Peyronie\u2019s Clinic , Orem, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Pattillo","sequence":"additional","affiliation":[{"name":"Brigham Young University , Provo, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Stirland","sequence":"additional","affiliation":[{"name":"Brigham Young University , Provo, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Flores","sequence":"additional","affiliation":[{"name":"CURE PD , Orem, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ziegelmann","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kohler","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevann","family":"Helo","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon","family":"Trost","sequence":"additional","affiliation":[{"name":"CURE PD , Orem, UT , United States"},{"name":"Brigham Young University , Provo, UT , United States"},{"name":"Male Fertility and Peyronie\u2019s Clinic , Orem, UT , United States"},{"name":"Mayo Clinic , Rochester, MN , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"282503","DOI":"10.1155\/2011\/282503","article-title":"A population-based study of Peyronie's disease: prevalence and treatment patterns in the United States","volume":"2011","author":"Dibenedetti","year":"2011","journal-title":"Advances Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1100\/tsw.2011.136","article-title":"Abnormalities of penile curvature: chordee and penile torsion","volume":"11","author":"Montag","year":"2011","journal-title":"Sci World J"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-5347(17)37988-0","article-title":"The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie's disease: results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000049830","article-title":"Peyronie's disease: prevalence and association with cigarette smoking. A multicenter population-based study in men aged 50-69 years","volume":"40","author":"La Pera","year":"2001","journal-title":"Eur Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1097\/01.ju.0000127744.18878.f1","article-title":"Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening","volume":"171","author":"Mulhall","year":"2004","journal-title":"J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1743-6109.2009.01655.x","article-title":"Peyronie's disease following radical prostatectomy: incidence and predictors","volume":"7","author":"Tal","year":"2010","journal-title":"J Sex Med"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ijir.3901518","article-title":"The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction","volume":"19","author":"Arafa","year":"2007","journal-title":"Int J Impot Res"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0022-5347(17)67140-4","article-title":"Embryogenesis of chordee","volume":"114","author":"Kaplan","year":"1975","journal-title":"J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"E7194","DOI":"10.1073\/pnas.1515981112","article-title":"Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies","volume":"112","author":"Zheng","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.sxmr.2018.09.007","article-title":"Review of management options for active-phase Peyronie's disease","volume":"7","author":"Brimley","year":"2019","journal-title":"Sex Med Rev."},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.sxmr.2019.06.004","article-title":"The etiology of Peyronie's disease: pathogenesis and genetic contributions","volume":"8","author":"Sharma","year":"2020","journal-title":"Sex Med Rev"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00345-019-02815-6","article-title":"A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease","volume":"38","author":"Patel","year":"2020","journal-title":"World J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1464-410X.2006.05969.x","article-title":"Risk factors for Peyronie's disease: a case-control study","volume":"97","author":"Bjekic","year":"2006","journal-title":"BJU Int"},{"key":"2023021713593426200_","first-page":"280","article-title":"Three anatomical levels: possibilities to decrease invasiveness of reconstructive surgery for congenital penile curvature","volume":"70","author":"Perdzynski","year":"2017","journal-title":"Cent European J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.juro.2013.01.087","article-title":"Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies","volume":"190","author":"Gelbard","year":"2013","journal-title":"J Urol"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"100321","DOI":"10.1016\/j.esxm.2021.100321","article-title":"Treatment patterns and healthcare outcomes with collagenase Clostridium histolyticum vs surgery in Peyronie's disease: a retrospective claims database analysis","volume":"9","author":"Trost","year":"2021","journal-title":"Sex Med"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.urology.2018.06.003","article-title":"Plaque calcification: an important predictor of collagenase Clostridium histolyticum treatment outcomes for men with Peyronie's disease","volume":"119","author":"Wymer","year":"2018","journal-title":"Urology"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.urology.2019.01.055","article-title":"Safety and efficacy of collagenase Clostridium histolyticum in Peyronie's disease men with ventral curvatures","volume":"129","author":"Alom","year":"2019","journal-title":"Urology"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.urology.2020.07.048","article-title":"Safety and efficacy of collagenase Clostridium histolyticum in the treatment of acute phase Peyronie's disease: a multi-institutional analysis","volume":"145","author":"Nguyen","year":"2020","journal-title":"Urology"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.urology.2017.04.045","article-title":"Self-reported clinical meaningfulness early in the treatment course predicts objective outcomes in men undergoing collagenase Clostridium histolyticum injections for Peyronie disease","volume":"106","author":"Ziegelmann","year":"2017","journal-title":"Urology"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jsxm.2019.03.007","article-title":"Efficacy of combined collagenase Clostridium histolyticum and RestoreX penile traction therapy in men with Peyronie's disease","volume":"16","author":"Alom","year":"2019","journal-title":"J Sex Med"},{"key":"2023021713593426200_","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jsxm.2021.11.017","article-title":"Surgical correction of adult congenital penile curvature: a systematic review","volume":"19","author":"Britton","year":"2022","journal-title":"J Sex Med"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/20\/2\/194\/49232761\/qdac006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/20\/2\/194\/49232761\/qdac006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T20:02:08Z","timestamp":1679342528000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/20\/2\/194\/6985888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,12]]},"published-print":{"date-parts":[[2023,2,14]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdac006","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"value":"1743-6095","type":"print"},{"value":"1743-6109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2023,1,12]]}}}