{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:38:02Z","timestamp":1762083482826,"version":"build-2065373602"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"OXAGON AB, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaginal atrophy is common after menopause and is often linked to sexual dysfunction, particularly dyspareunia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to investigate the effect of intravaginally applied oxytocin on expressions of vaginal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty postmenopausal women aged 47 to 66\u00a0years with vaginal atrophy participated in this double-blinded placebo-controlled study. The women were randomized to intravaginal treatment with either gel with 600\u00a0IU\/mL of oxytocin (oxytocin group) or gel alone (control group) once daily for 2 weeks. The gel consisted of hypromellose, pH 3.8 (Vagovital).<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>The color of the vaginal mucosa, the vaginal pH, and the cytology of vaginal epithelial cells were investigated before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The color of the vaginal mucosa shifted from pale to red in all 25 patients treated with oxytocin but only in 4 patients in the control group (P\u2009&amp;lt;\u2009.001). There was a significant decrease in intravaginal pH in the oxytocin group and the control group, with the delta value being significantly greater in the oxytocin group than in the control group (P\u2009&amp;lt;\u2009.001). The vaginal maturation index increased significantly (P\u2009&amp;lt;\u2009.001) in the oxytocin group but not in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>Topical oxytocin gel offers an effective solution to the sexual dysfunction that is related to vaginal atrophy after menopause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths and Limitations<\/jats:title><jats:p>Strengths include studying different outcomes of applying the oxytocin gel for vaginal atrophy. Limitations include the small-scale population with a relatively short duration of treatment (2\u00a0weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intravaginal treatment with a gel containing 600\u00a0IU\/mL of oxytocin effectively counteracts physical expressions of vaginal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov (NCT05275270; https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05275270).<\/jats:p><\/jats:sec>","DOI":"10.1093\/jsxmed\/qdac021","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T10:17:41Z","timestamp":1673518661000},"page":"177-183","source":"Crossref","is-referenced-by-count":3,"title":["Effect of topical oxytocin gel on vaginal mucosa in postmenopausal Egyptian women: a clinical randomized trial"],"prefix":"10.1093","volume":"20","author":[{"given":"Asem","family":"Moussa","sequence":"first","affiliation":[{"name":"Al-Azhar University Obstetrics and Gynecology Department, Faculty of Medicine, , Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin Uvn\u00e4s","family":"Moberg","sequence":"additional","affiliation":[{"name":"Swedish University of Agricultural Sciences Animal Environment and Health Department, , Skara, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael","family":"Elgrahy","sequence":"additional","affiliation":[{"name":"Al-Azhar University Obstetrics and Gynecology Department, Faculty of Medicine, , Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Elsayied","sequence":"additional","affiliation":[{"name":"El Galaa Teaching Hospital Obstetrics and Gynecology Department, , Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Abdel-Rasheed","sequence":"additional","affiliation":[{"name":"National Research Centre Reproductive Health Research Department, , 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