{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:20:04Z","timestamp":1776435604899,"version":"3.51.2"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA197077"],"award-info":[{"award-number":["K07CA197077"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001252","name":"Mount Zion Health Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Women diagnosed with colorectal cancer (CRC) or anal squamous cell carcinoma (ASCC) are at high risk of sexual dysfunction after treatment, yet little is known about recovery and risk factors for chronic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to describe sexual function and sexual activity among women who underwent definitive treatment for CRC or ASCC, examine relationships between time since treatment completion and sexual function, and explore factors associated with desire and changes in sexual desire over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of a prospective cohort study of patients with gastrointestinal cancer at the University of California San Francisco, female-identifying participants who finished definitive treatment for CRC or ASCC completed the Female Sexual Function Index (FSFI) at 6- to 12-month intervals. We used multivariable linear mixed models to explore factors associated with the FSFI desire subscale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Outcomes were rates of sexual activity, proportion at risk for sexual dysfunction (FSFI score\u2009&amp;lt;26.55), total FSFI score, and FSFI desire subscale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 97 cancer survivors who completed at least 1 FSFI, the median age was 59\u00a0years, the median time since treatment end was 14\u00a0months, and 87% were menopausal. Fifty-five women (57%) had a history of colon cancer; 21 (22%), rectal cancer; and 21 (22%), ASCC. An additional 13 (13%) had a current ostomy. Approximately half the women were sexually active (n\u2009=\u200948, 49%). Among these 48 sexually active women, 34 (71%) had FSFI scores indicating risk for sexual dysfunction. Among the 10 sexually active women who completed a FSFI \u22652\u00a0years since end of treatment, the median total score was 22.6 (IQR, 15.6-27.3). None of the evaluated characteristics were associated with desire (age, tumor site, treatment, menopause status, or ostomy status).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>Consistent with prior studies, we found low desire scores after treatment for CRC or ASCC, with little recovery over time, suggesting that patients should not expect an eventual rebound of sexual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths and Limitations<\/jats:title><jats:p>Strengths of our study include longitudinal data and use of the validated FSFI. Women with ASCC composed 22% of our cohort, allowing for insight into this rare disease group. Limitations of this study include the small sample size, particularly for longitudinal analyses, and the enrollment of patients at variable times since treatment end.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a high prevalence of sexual health concerns, including low desire, after the treatment of CRC and ASCC that persisted for years after treatment was completed.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jsxmed\/qdac047","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T19:52:56Z","timestamp":1676749976000},"page":"439-446","source":"Crossref","is-referenced-by-count":10,"title":["Sexual function remains persistently low in women after treatment for colorectal cancer and anal squamous cell carcinoma"],"prefix":"10.1093","volume":"20","author":[{"given":"Marissa B","family":"Savoie","sequence":"first","affiliation":[{"name":"School of Medicine, University of California San Francisco , San Francisco, CA 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Diller Family Comprehensive Cancer Center, University of California San Francisco , San Francisco, CA 94143 , United States"},{"name":"Department of Radiation Oncology, University of California San Francisco , San Francisco, CA 94143 , United States"},{"name":"Department of Electrical Engineering and Computer Sciences, University of California Berkeley , Berkeley, CA 94720 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe E","family":"Atreya","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center, University of California San Francisco , San Francisco, CA 94143 , United States"},{"name":"Division of Hematology and Oncology, Department of Medicine, University of California San Francisco , San Francisco, CA 94143 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Connor","family":"Johnson","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02115 , 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