{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:17:43Z","timestamp":1785777463737,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA218657"],"award-info":[{"award-number":["R01CA218657"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anodyspareunia may be an adverse outcome of prostate cancer (PCa) treatment for gay, bisexual, and other men who have sex with men (GBM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aims of this study were to (1) describe the clinical symptoms of painful receptive anal intercourse (RAI) in GBM following PCa treatment, (2) estimate the prevalence of anodyspareunia, and (3) identify clinical and psychosocial correlates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a secondary analysis of baseline and 24-month follow-up data from the Restore-2 randomized clinical trial of 401 GBM treated for PCa. The analytic sample included only those participants who attempted RAI during or since their PCa treatment (N\u2009=\u2009195).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>Anodyspareunia was operationalized as moderate to severe pain during RAI for \u22656 months that resulted in mild to severe distress. Additional quality-of-life outcomes included the Expanded Prostate Cancer Index Composite (bowel function and bother subscales), the Brief Symptom Inventory\u201318, and the Functional Assessment of Cancer Therapy\u2013Prostate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall 82 (42.1%) participants reported pain during RAI since completing PCa treatment. Of these, 45.1% experienced painful RAI sometimes or frequently, and 63.0% indicated that the pain was persistent. The pain at its worst was moderate to very severe for 79.0%. The experience of pain was at least mildly distressing for 63.5%. Painful RAI worsened for a third (33.4%) of participants after completing PCa treatment. Of the 82 GBM, 15.4% were classified as meeting criteria for anodyspareunia. Antecedents of anodyspareunia included a lifelong history of painful RAI and bowel dysfunction following PCa treatment. Those reporting symptoms of anodyspareunia were more likely to avoid RAI due to pain (adjusted odds ratio,\u00a04.37), which was negatively associated with sexual satisfaction (mean difference, \u22122.77) and self-esteem (mean difference, \u22123.33). The model explained 37.2% of the variance in overall quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Culturally responsive PCa care should include the assessment of anodyspareunia among GBM and explore treatment options.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>This is the largest study to date focused on anodyspareunia among GBM treated for PCa. Anodyspareunia was assessed with multiple items characterizing the intensity, duration, and distress related to painful RAI. The external validity of the findings is limited by the nonprobability sample. Furthermore, the cause-and-effect relationships between the reported associations cannot be established by the research design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Anodyspareunia should be considered a sexual dysfunction in GBM and investigated as an adverse outcome of PCa treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdad009","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T01:39:27Z","timestamp":1676597967000},"page":"515-524","source":"Crossref","is-referenced-by-count":12,"title":["Unrecognized sexual dysfunction in gay and bisexual men after prostate cancer treatment: the antecedents and impact of anodyspareunia"],"prefix":"10.1093","volume":"20","author":[{"given":"Christopher W","family":"Wheldon","sequence":"first","affiliation":[{"name":"College of Public Health, Temple University Department of Social and Behavioral Sciences, , Philadelphia, P A","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-4855","authenticated-orcid":false,"given":"Alex J","family":"Bates","sequence":"additional","affiliation":[{"name":"University of Minnesota Division of Epidemiology and Community Health, School of Public Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Polter","sequence":"additional","affiliation":[{"name":"University of Minnesota Division of Epidemiology and Community Health, School of Public Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R Simon","family":"Rosser","sequence":"additional","affiliation":[{"name":"University of Minnesota Division of Epidemiology and Community Health, School of Public Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Trinity Teleradiology Services Department of Radiology, , Vancouver, BC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M C","family":"Talley","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Nursing School Adult and Gerontological Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Haggart","sequence":"additional","affiliation":[{"name":"University of Minnesota Department of Urology, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Kohli","sequence":"additional","affiliation":[{"name":"University of Minnesota Department of Educational Psychology, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrinath R","family":"Konety","sequence":"additional","affiliation":[{"name":"Rush Medical College Department of Urology, , Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl","family":"Mitteldorf","sequence":"additional","affiliation":[{"name":"Malecare Cancer Support , New York, New York ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"Ross","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School Department of Family Medicine and Community Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"West","sequence":"additional","affiliation":[{"name":"University of Minnesota Department of Writing Studies, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Minnesota Division of Epidemiology and Community Health, School of Public Health, , Minneapolis, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"2025052713415169700_ref1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jsxm.2019.05.019","article-title":"Sexual function in patients treated with stereotactic radiotherapy for prostate cancer: a systematic review of the current evidence","volume":"16","author":"Loi","year":"2019","journal-title":"J Sex Med"},{"key":"2025052713415169700_ref2","first-page":"CD006590","article-title":"Radical prostatectomy versus deferred treatment for localised prostate cancer","volume":"6","author":"Vernooij","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"2025052713415169700_ref3","volume-title":"Gay & Bisexual Men Living with ProstateCancer"},{"key":"2025052713415169700_ref4","article-title":"Sexual dysfunction in gay and bisexual prostate cancer survivors: a concept analysis","volume":"69","author":"Mitchell","journal-title":"J Homosex"},{"key":"2025052713415169700_ref5","first-page":"7599","article-title":"A systematic review of Expanded Prostate Cancer Index Composite (EPIC) quality of life after surgery or radiation treatment","volume":"22","author":"Lee","year":"2015","journal-title":"Can J Urol"},{"key":"2025052713415169700_ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/pcan.2013.1","article-title":"Measuring symptoms in localized prostate cancer: a systematic review of assessment instruments","volume":"16","author":"Rnic","year":"2013","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"2025052713415169700_ref7","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.21037\/tau-20-1052","article-title":"Every urologist and oncologist should know about treating sexual and gender minority prostate cancer patients: translating research findings into clinical practice","volume":"10","author":"Rosser","year":"2021","journal-title":"Transl Androl Urol"},{"key":"2025052713415169700_ref8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jsxm.2016.01.015","article-title":"Sexual behaviors of US men by self-identified sexual orientation: results from the 2012 National Survey of Sexual Health and Behavior","volume":"13","author":"Dodge","year":"2016","journal-title":"J Sex Med"},{"key":"2025052713415169700_ref9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/lgbt.2018.0245","article-title":"A pilot study assessing aspects of sexual function predicted to be important after treatment for prostate cancer in gay men: an underserved domain highlighted","volume":"7","author":"Amarasekera","year":"2020","journal-title":"LGBT Health"},{"key":"2025052713415169700_ref10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ca.23006","article-title":"Prostate-induced orgasms: a concise review illustrated with a highly relevant case study\u2014prostate-induced orgasms","volume":"31","author":"Levin","year":"2018","journal-title":"Clin Anat"},{"key":"2025052713415169700_ref11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00384-015-2289-4","article-title":"Chronic radiation proctitis: tricks to prevent and treat","volume":"30","author":"Vanneste","year":"2015","journal-title":"Int J Color Dis"},{"key":"2025052713415169700_ref12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/14681990701481409","article-title":"Anodyspareunia: a novel sexual dysfunction? An exploration into anal sexuality","volume":"22","author":"Hollows","year":"2007","journal-title":"Sex Relatsh Ther"},{"key":"2025052713415169700_ref13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.sxmr.2021.01.002","article-title":"Sexual dysfunction in men who have sex with men","volume":"10","author":"Cheng","year":"2022","journal-title":"Sex Med Rev"},{"key":"2025052713415169700_ref14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.18192\/uojm.v7i2.2198","article-title":"Genito-pelvic pain\/penetration disorder (GPPPD): an overview of current terminology, etiology, and treatment","volume":"7","author":"Conforti","year":"2017","journal-title":"UOJM"},{"key":"2025052713415169700_ref15","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1002\/cncr.26739","article-title":"Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors: FSFI validation in cancer survivors","volume":"118","author":"Baser","year":"2012","journal-title":"Cancer"},{"key":"2025052713415169700_ref16","article-title":"Pelvic floor disorders in women with gynecologic malignancies: a systematic review","volume":"29","author":"Ramaseshan","journal-title":"Int Urogynecol J"},{"key":"2025052713415169700_ref17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1159\/000506148","article-title":"Efficacy and safety of treatments to improve dyspareunia in breast cancer survivors: a systematic review","volume":"15","author":"Mendoza","year":"2020","journal-title":"Breast Care (Basel)"},{"key":"2025052713415169700_ref18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jsxm.2020.01.020","article-title":"Sexual anal pain in gay and bisexual men: in search of explanatory factors","volume":"17","author":"Grabski","year":"2020","journal-title":"J Sex Med"},{"key":"2025052713415169700_ref19","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1995.03520250075037","article-title":"Linking clinical variables with health-related quality of life: a conceptual model of patient outcomes","volume":"273","author":"Wilson","year":"1995","journal-title":"JAMA"},{"key":"2025052713415169700_ref20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00384-013-1784-8","article-title":"Systematic review: anal and rectal changes after radiotherapy for prostate cancer","volume":"29","author":"Krol","year":"2014","journal-title":"Int J Color Dis"},{"key":"2025052713415169700_ref21","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0277-9536(97)00058-0","article-title":"Dimensions of quality of life expressed by men treated for metastatic prostate cancer","volume":"45","author":"Clark","year":"1997","journal-title":"Soc Sci Med"},{"key":"2025052713415169700_ref22","volume-title":"American Community Survey","author":"US Census Bureau","year":"2018"},{"key":"2025052713415169700_ref23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0090-4295(00)00858-X","article-title":"Development and validation of the Expanded Prostate Cancer Index Composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer","volume":"56","author":"Wei","year":"2000","journal-title":"Urol."},{"key":"2025052713415169700_ref24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00849744","article-title":"The Multidimensional Sexuality Questionnaire: an objective self-report measure of psychological tendencies associated with human sexuality","volume":"6","author":"Snell","year":"1993","journal-title":"Ann Sex Res"},{"key":"2025052713415169700_ref25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12874-018-0631-6","article-title":"Norm values and psychometric properties of the Brief Symptom Inventory\u201318 regarding individuals between the ages of 60 and 95","volume":"18","author":"Petrowski","year":"2018","journal-title":"BMC Med Res Methodol"},{"key":"2025052713415169700_ref26","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0090-4295(97)00459-7","article-title":"Measuring quality of life in men with prostate cancer using the Functional Assessment of Cancer Therapy\u2013Prostate instrument","volume":"50","author":"Esper","year":"1997","journal-title":"Urol"},{"key":"2025052713415169700_ref27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/sm2.6","article-title":"The Gay Men Sex Studies: anodyspareunia among Belgian gay men","volume":"1","author":"Vansintejan","year":"2013","journal-title":"Sex Med"},{"key":"2025052713415169700_ref28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jsxm.2018.12.010","article-title":"Stigma on the streets, dissatisfaction in the sheets: is minority stress associated with decreased sexual functioning among young men who have sex with men?","volume":"16","author":"Li","year":"2019","journal-title":"J Sex Med"},{"key":"2025052713415169700_ref29","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1001\/jama.2017.1704","article-title":"Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years","volume":"317","author":"Barocas","year":"2017","journal-title":"JAMA"},{"key":"2025052713415169700_ref30","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"2025052713415169700_ref31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cnur.2020.05.003","article-title":"Proctitis in men who have sex with men","volume":"55","author":"Steed","year":"2020","journal-title":"Nurs Clin North Am"},{"key":"2025052713415169700_ref32","article-title":"Current treatment and future directions in the management of anal cancer","volume":"72","author":"Tchelebi","journal-title":"CA A Cancer J Clin"},{"key":"2025052713415169700_ref33","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/nau.22654","article-title":"Pelvic floor muscle training for bowel dysfunction following colorectal cancer surgery: a systematic review\u2014pelvic floor muscle training in bowel cancer","volume":"34","author":"Lin","year":"2015","journal-title":"Neurourol Urodyn"},{"key":"2025052713415169700_ref34","article-title":"Pelvic floor involvement in male and female sexual dysfunction and the role of pelvic floor rehabilitation in treatment: a literature review","volume":"4","author":"Rosenbaum","journal-title":"J Sex Med"},{"key":"2025052713415169700_ref35","first-page":"CD007291","article-title":"Vaginal dilator therapy for women receiving pelvic radiotherapy","author":"Miles","year":"2014","journal-title":"Cochrane Database Syst Rev"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/20\/4\/515\/49714677\/qdad009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/20\/4\/515\/49714677\/qdad009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:42:02Z","timestamp":1748367722000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/20\/4\/515\/7043314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2,16]]},"published-print":{"date-parts":[[2023,3,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdad009","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"value":"1743-6095","type":"print"},{"value":"1743-6109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4]]},"published":{"date-parts":[[2023,2,16]]}}}