{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:04:24Z","timestamp":1793149464350,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771573"],"award-info":[{"award-number":["81771573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Corpus cavernosum (CC) fibrosis significantly contributes to post\u2013radical prostatectomy erectile dysfunction (pRP-ED). Caveolin-1 scaffolding domain (CSD)\u2013derived peptide has gained significant concern as a potent antagonist of tissue fibrosis. However, applying CSD peptide on bilateral cavernous nerve injury (BCNI)\u2013induced rats remains uninvestigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim was to explore the therapeutic outcome and underlying mechanism of CSD peptide for preventing ED in BCNI rats according to the hypothesis that CSD peptide may exert beneficial effects on erectile tissue and function following BCNI through limiting collagen synthesis in CC smooth muscle cells (CCSMCs) and CC fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>After completing a random assignment of male Sprague Dawley rats (10 weeks of age), BCNI rats received either saline or CSD peptide treatment, as opposed to sham-operated rats. The evaluations of erectile function (EF) and succedent collection and histological and molecular biological examinations of penile tissue were accomplished 3\u00a0weeks postoperatively. In addition, the fibrotic model of CCSMCs was used to further explore the mechanism of CSD peptide action in vitro.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The assessments of EF, SMC\/collagen ratio, \u03b1-smooth muscle actin, caveolin-1 (CAV1), and profibrotic indicators expressions were conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BCNI rats exhibited significant decreases in EF, SMC\/collagen ratio, \u03b1-SMA, and CAV1 levels, and increases in collagen content together with transforming growth factor (TGF)-\u03b21\/Smad2 activity. However, impaired EF, activated CC fibrosis, and Smad2 signaling were attenuated after 3\u00a0weeks of CSD peptide treatment in BCNI rats. In vitro, TGF-\u03b21\u2013induced CCSMCs underwent fibrogenetic transformation characterized by lower expression of CAV1, higher collagen composition, and phosphorylation of Smad2; then, the delivery of CSD peptide could significantly block CCSMC fibrosis by inactivating Smad2 signaling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Based on available evidence of CSD peptide in the prevention of ED in BCNI rats, this study can aid in the development and clinical application of CSD peptide targeting pRP-ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>This study provides data to suggest that CSD peptide protects against BCNI-induced deleterious alterations in EF and CC tissues. However, the available evidence still does not fully clarify the detailed mechanism of action of CSD peptide.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Administration of CSD peptide significantly retarded collagen synthesis in CCSMCs, limited CC fibrosis, and prevented ED via confrontation of TGF-\u03b21\/Smad signaling in BCNI rats.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdad108","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T11:18:26Z","timestamp":1695122306000},"page":"1274-1284","source":"Crossref","is-referenced-by-count":18,"title":["Caveolin-1 scaffolding domain peptide prevents corpus cavernosum fibrosis and erectile dysfunction in bilateral cavernous nerve injury\u2013induced rats"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8722-0761","authenticated-orcid":false,"given":"Yuhang","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-1780","authenticated-orcid":false,"given":"Yunlong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"},{"name":"Department of Urology, The Sixth Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong 020-510000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"issue":"4","key":"2023110702383273200_ref1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.eururo.2016.08.003","article-title":"EAU-ESTRO-SIOG guidelines on prostate cancer. 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