{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:48:15Z","timestamp":1762177695476,"version":"3.37.3"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2B5B02001671"],"award-info":[{"award-number":["NRF-2022R1A2B5B02001671"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Government"},{"name":"Inha University Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Heparin-binding epidermal growth factor\u2013like growth factor (HB-EGF) serves as a pro-angiogenic factor; however, there is to our knowledge currently no reported research on the relationship between HB-EGF and diabetic erectile dysfunction (ED).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>In this study we aimed to determine whether HB-EGF can improve the erectile function of streptozotocin-induced diabetic mice and to explore the related mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eight-week-old male C57BL\/6 mice were used for diabetes induction. Diabetes mellitus (DM) was induced by low-dose injections of streptozotocin (50\u00a0mg\/kg) for 5 consecutive days. Eight weeks after streptozotocin injections, DM was determined by measuring blood glucose and body weight. Diabetic mice were treated with two intracavernous administrations of phosphate-buffered saline (20\u00a0\u03bcL) or various doses of HB-EGF (days \u22123 and 0; 1, 5, and 10\u00a0\u03bcg in 20\u00a0\u03bcL of phosphate-buffered saline). The angiogenesis effect of HB-EGF was confirmed by tube formation and migration assays in mouse cavernous endothelial cells and mouse cavernous pericytes under high-glucose conditions. Erectile function was measured by electrical stimulation of the cavernous nerve, as well as histological examination and Western blot analysis for mechanism assessment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>In vitro angiogenesis, cell proliferation, in vivo intracavernous pressure, neurovascular regeneration, cavernous permeability, and survival signaling were the outcomes measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Expression of HB-EGF was reduced under diabetic conditions. Exogenous HB-EGF induced angiogenesis in mouse cavernous endothelial cells and mouse cavernous pericytes under high-glucose conditions. Erectile function was decreased in the DM group, whereas administration of HB-EGF resulted in a significant improvement of erectile function (91% of the age-matched control group) in association with increased neurovascular content, including cavernous endothelial cells, pericytes, and neuronal cells. Histological and Western blot analyses revealed a significant increase in the permeability of the corpus cavernosum in DM mice, which was attenuated by HB-EGF treatment. The protein expression of phospho-Akt Ser473 and phosphorylated endothelial nitric oxide synthase Ser1177 increased after HB-EGF treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>The use of HB-EGF may be an effective strategy to treat ED associated with DM or other neurovascular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>Similarly to other pro-angiogenic factors, HB-EGF has dual roles in vascular and neuronal development. Our study focused on broadly evaluating the role of HB-EGF in diabetic ED. In view of the properties of HB-EGF as an angiogenic factor, its dose concentration should be strictly controlled to avoid potential side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In the diabetic ED mouse model in this study erectile function was improved by HB-EGF, which may provide new treatment strategies for patients with ED who do not respond to phosphodiesterase 5 Inhibitors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdae079","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T02:04:38Z","timestamp":1721527478000},"page":"751-761","source":"Crossref","is-referenced-by-count":1,"title":["Heparin-binding epidermal growth factor\u2013like growth factor improves erectile function in streptozotocin-induced diabetic mice"],"prefix":"10.1093","volume":"21","author":[{"given":"Fitri Rahma","family":"Fridayana","sequence":"first","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"},{"name":"Program in Biomedical Science & Engineering, Inha University , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyeon","family":"Ock","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lashkari","family":"Niloofar","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"},{"name":"Program in Biomedical Science & Engineering, Inha University , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Nhat","family":"Vo","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"},{"name":"Program in Biomedical Science & Engineering, Inha University , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Nan","family":"Yin","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Kan","family":"Ryu","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine , Incheon 22332 , Republic of Korea"},{"name":"Program in Biomedical Science & Engineering, Inha University , Incheon 22332 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"issue":"3","key":"2024090406284167800_ref1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.14336\/AD.2021.1104","article-title":"DR1 activation inhibits the proliferation of vascular smooth muscle cells through increasing endogenous H(2)S in diabetes","volume":"13","author":"Xi","year":"2022","journal-title":"Aging Dis"},{"issue":"2","key":"2024090406284167800_ref2","doi-asserted-by":"crossref","first-page":"e3494","DOI":"10.1002\/dmrr.3494","article-title":"Erectile dysfunction and diabetes: a melting pot of circumstances and treatments","volume":"38","author":"Defeudis","year":"2022","journal-title":"Diabetes Metab Res Rev"},{"issue":"6 Suppl","key":"2024090406284167800_ref3","first-page":"S17","article-title":"Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease","volume":"24","author":"Bivalacqua","year":"2003","journal-title":"J Androl"},{"issue":"1","key":"2024090406284167800_ref4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11892-002-0059-5","article-title":"Erectile dysfunction and diabetes","volume":"2","author":"Chu","year":"2002","journal-title":"Curr Diab Rep"},{"issue":"2","key":"2024090406284167800_ref5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jacc.2003.07.042","article-title":"Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease","volume":"43","author":"Kaiser","year":"2004","journal-title":"J Am Coll Cardiol"},{"journal-title":"Elife","article-title":"Single cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction","author":"Bae","key":"2024090406284167800_ref6"},{"issue":"1","key":"2024090406284167800_ref7","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1038\/s41467-022-30633-9","article-title":"Identification, discrimination and heterogeneity of fibroblasts","volume":"13","author":"Lendahl","year":"2022","journal-title":"Nat Commun"},{"key":"2024090406284167800_ref8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2014.03.004","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): a regulator of several pathways","volume":"28","author":"Taylor","year":"2014","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"2024090406284167800_ref9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41536-021-00189-1","article-title":"VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes","volume":"6","author":"White","year":"2021","journal-title":"NPJ Regen Med"},{"issue":"1","key":"2024090406284167800_ref10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12964-022-00983-4","article-title":"HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1\/2 signaling in human granulosa-lutein cells","volume":"20","author":"Cheng","year":"2022","journal-title":"Cell Commun Signal"},{"issue":"3","key":"2024090406284167800_ref11","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/hep.31076","article-title":"TMPRSS4 drives angiogenesis in hepatocellular carcinoma by promoting HB-EGF expression and proteolytic cleavage","volume":"72","author":"Dong","year":"2020","journal-title":"Hepatology"},{"issue":"5","key":"2024090406284167800_ref12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1432-0436.2007.00250.x","article-title":"Heparin-binding epidermal growth factor-like growth factor inhibits adipocyte differentiation at commitment and early induction stages","volume":"76","author":"Lee","year":"2008","journal-title":"Differentiation"},{"issue":"3","key":"2024090406284167800_ref13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2337\/db19-0643","article-title":"HB-EGF signaling is required for glucose-induced pancreatic beta-cell proliferation in rats","volume":"69","author":"Maachi","year":"2020","journal-title":"Diabetes"},{"issue":"12","key":"2024090406284167800_ref14","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1111\/j.1743-6109.2009.01464.x","article-title":"Functional and morphologic characterizations of the diabetic mouse corpus cavernosum: comparison of a multiple low-dose and a single high-dose streptozotocin protocols","volume":"6","author":"Jin","year":"2009","journal-title":"J Sex Med"},{"issue":"4","key":"2024090406284167800_ref15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.ijir.3901314","article-title":"Water-soluble lipopolymer as a gene carrier to corpus cavernosum","volume":"17","author":"Lee","year":"2005","journal-title":"Int J Impot Res"},{"issue":"7","key":"2024090406284167800_ref16","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1743-6109.2012.02752.x","article-title":"Matrigel-based sprouting endothelial cell culture system from mouse corpus cavernosum is potentially useful for the study of endothelial and erectile dysfunction related to high-glucose exposure","volume":"9","author":"Yin","year":"2012","journal-title":"J Sex Med"},{"issue":"1","key":"2024090406284167800_ref17","doi-asserted-by":"crossref","first-page":"10891","DOI":"10.1038\/srep10891","article-title":"The pericyte as a cellular regulator of penile erection and a novel therapeutic target for erectile dysfunction","volume":"5","author":"Yin","year":"2015","journal-title":"Sci Rep"},{"issue":"7","key":"2024090406284167800_ref18","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2337\/diabetes.54.7.2179","article-title":"Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process","volume":"54","author":"Detaille","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"2024090406284167800_ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5534\/wjmh.180091","article-title":"A simple and nonenzymatic method to isolate human corpus Cavernosum endothelial cells and Pericytes for the study of erectile dysfunction","volume":"38","author":"Yin","year":"2020","journal-title":"World J Mens Health"},{"issue":"4","key":"2024090406284167800_ref20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4111\/icu.20220038","article-title":"Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice","volume":"63","author":"Yin","year":"2022","journal-title":"Investig Clin Urol"},{"issue":"26","key":"2024090406284167800_ref21","doi-asserted-by":"crossref","first-page":"E2731","DOI":"10.1073\/pnas.1403471111","article-title":"Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse","volume":"111","author":"Yin","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024090406284167800_ref22","first-page":"79","article-title":"Abstract reasoning in age-related neurological disease","volume":"24","author":"Cronin-Golomb","year":"1987","journal-title":"J Neural Transm Suppl"},{"issue":"4","key":"2024090406284167800_ref23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/08977190701773070","article-title":"HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways","volume":"25","author":"Mehta","year":"2007","journal-title":"Growth Factors"},{"issue":"3","key":"2024090406284167800_ref24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jdermsci.2009.06.002","article-title":"HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells","volume":"55","author":"Nakai","year":"2009","journal-title":"J Dermatol Sci"},{"issue":"3","key":"2024090406284167800_ref25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.urology.2005.03.058","article-title":"Application of angiogenic factors for therapy of erectile dysfunction: protein and DNA transfer of VEGF 165 into the rat penis","volume":"66","author":"Burchardt","year":"2005","journal-title":"Urology"},{"issue":"3","key":"2024090406284167800_ref26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2337\/db10-0354","article-title":"Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse","volume":"60","author":"Jin","year":"2011","journal-title":"Diabetes"},{"issue":"12","key":"2024090406284167800_ref27","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1111\/jsm.12278","article-title":"Effect of intracavernous administration of angiopoietin-4 on erectile function in the streptozotocin-induced diabetic mouse","volume":"10","author":"Kwon","year":"2013","journal-title":"J Sex Med"},{"issue":"11","key":"2024090406284167800_ref28","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.jsxm.2016.09.017","article-title":"Effectiveness of Intracavernous delivery of recombinant human hepatocyte growth factor on erectile function in the Streptozotocin-induced diabetic mouse","volume":"13","author":"Das","year":"2016","journal-title":"J Sex Med"},{"issue":"6","key":"2024090406284167800_ref29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2337\/db17-0833","article-title":"Pericyte-derived Dickkopf2 regenerates damaged penile neurovasculature through an Angiopoietin-1-Tie2 pathway","volume":"67","author":"Yin","year":"2018","journal-title":"Diabetes"},{"issue":"5","key":"2024090406284167800_ref30","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s12276-022-00773-5","article-title":"Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function","volume":"54","author":"Yin","year":"2022","journal-title":"Exp Mol Med"},{"issue":"3","key":"2024090406284167800_ref31","doi-asserted-by":"crossref","first-page":"e12924","DOI":"10.1111\/and.12924","article-title":"Essential role of brain-derived neurotrophic factor (bdnf) in diabetic erectile dysfunction","volume":"50","author":"Hu","year":"2018","journal-title":"Andrologia"},{"issue":"5","key":"2024090406284167800_ref32","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1097\/01.ju.0000158056.66236.1f","article-title":"Improvement in erectile dysfunction after neurotrophic factor gene therapy in diabetic rats","volume":"173","author":"Bennett","year":"2005","journal-title":"J Urol"},{"issue":"4","key":"2024090406284167800_ref33","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001945R","article-title":"Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin\/orexin expression","volume":"35","author":"Xiang","year":"2021","journal-title":"FASEB J"},{"issue":"3","key":"2024090406284167800_ref34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000319823","article-title":"Heparin-binding epidermal growth factor-like growth factor is a potent neurotrophic factor for PC12 cells","volume":"18","author":"Zhou","year":"2010","journal-title":"Neurosignals"},{"issue":"22","key":"2024090406284167800_ref35","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1182\/blood-2010-05-286872","article-title":"Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization","volume":"116","author":"Stratman","year":"2010","journal-title":"Blood"},{"issue":"9","key":"2024090406284167800_ref36","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.7150\/ijbs.72243","article-title":"Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice","volume":"18","author":"Anita","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"9","key":"2024090406284167800_ref37","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.7150\/ijbs.81809","article-title":"Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury","volume":"19","author":"Ock","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"3","key":"2024090406284167800_ref38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.RES.81.3.363","article-title":"High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha","volume":"81","author":"Hempel","year":"1997","journal-title":"Circ Res"},{"issue":"2","key":"2024090406284167800_ref39","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/andr.13234","article-title":"IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice","volume":"11","author":"Ock","year":"2023","journal-title":"Andrology"},{"issue":"2","key":"2024090406284167800_ref40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/andr.12307","article-title":"Establishment of in vitro model of erectile dysfunction for the study of high-glucose-induced angiopathy and neuropathy","volume":"5","author":"Yin","year":"2017","journal-title":"Andrology"},{"issue":"6","key":"2024090406284167800_ref41","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jpedsurg.2013.03.030","article-title":"Heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from radiation therapy-induced intestinal injury","volume":"48","author":"Matthews","year":"2013","journal-title":"J Pediatr Surg"},{"issue":"1","key":"2024090406284167800_ref42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/pr.2015.63","article-title":"Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice","volume":"78","author":"Wei","year":"2015","journal-title":"Pediatr Res"},{"issue":"1","key":"2024090406284167800_ref43","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1038\/srep26794","article-title":"Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus","volume":"6","author":"Shim","year":"2016","journal-title":"Sci Rep"},{"issue":"6","key":"2024090406284167800_ref44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/08977190802393596","article-title":"HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis","volume":"26","author":"Mehta","year":"2008","journal-title":"Growth Factors"},{"issue":"Suppl 2","key":"2024090406284167800_ref45","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.33549\/physiolres.934345","article-title":"The PI3k\/Akt pathway is associated with angiogenesis, oxidative stress and survival of mesenchymal stem cells in pathophysiologic condition in ischemia","volume":"68","author":"Samakova","year":"2019","journal-title":"Physiol Res"},{"issue":"5","key":"2024090406284167800_ref46","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/1753-0407.12521","article-title":"Macro- and microvascular endothelial dysfunction in diabetes","volume":"9","author":"Shi","year":"2017","journal-title":"J Diabetes"},{"issue":"5","key":"2024090406284167800_ref47","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1158\/1541-7786.MCR-12-0428","article-title":"Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer","volume":"11","author":"Yotsumoto","year":"2013","journal-title":"Mol Cancer Res"},{"issue":"1-2","key":"2024090406284167800_ref48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0165-3806(98)00057-1","article-title":"Neuronal and glial expression of heparin-binding EGF-like growth factor in central nervous system of prenatal and early-postnatal rat","volume":"108","author":"Nakagawa","year":"1998","journal-title":"Brain Res Dev Brain Res"},{"issue":"3","key":"2024090406284167800_ref49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s007020200022","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons","volume":"109","author":"Farkas","year":"2002","journal-title":"J Neural Transm (Vienna)"},{"issue":"2","key":"2024090406284167800_ref50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/andr.13475","article-title":"BMP2 restores erectile dysfunction through neurovascular regeneration and fibrosis reduction in diabetic mice","volume":"12","author":"Kwon","year":"2024","journal-title":"Andrology."},{"issue":"1","key":"2024090406284167800_ref51","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41598-020-80925-7","article-title":"Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice","volume":"11","author":"Song","year":"2021","journal-title":"Sci Rep"},{"issue":"5","key":"2024090406284167800_ref52","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/andr.12784","article-title":"Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse","volume":"8","author":"Song","year":"2020","journal-title":"Andrology"},{"issue":"1","key":"2024090406284167800_ref53","doi-asserted-by":"crossref","first-page":"20072","DOI":"10.1038\/s41598-019-54431-4","article-title":"Embryonic stem cell-derived extracellular vesicle-mimetic nanovesicles rescue erectile function by enhancing penile neurovascular regeneration in the streptozotocin-induced diabetic mouse","volume":"9","author":"Kwon","year":"2019","journal-title":"Sci Rep"},{"issue":"3","key":"2024090406284167800_ref54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jsxm.2019.01.013","article-title":"Inhibition of proNGF and p75(NTR) pathway restores erectile function through dual Angiogenic and neurotrophic effects in the diabetic mouse","volume":"16","author":"Nguyen","year":"2019","journal-title":"J Sex Med"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/21\/9\/751\/59002147\/qdae079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/21\/9\/751\/59002147\/qdae079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T23:48:01Z","timestamp":1725493681000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/21\/9\/751\/7717613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,20]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,7,20]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdae079","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"type":"print","value":"1743-6095"},{"type":"electronic","value":"1743-6109"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,20]]}}}