{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:38:25Z","timestamp":1787881105029,"version":"build-2784847793"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071637"],"award-info":[{"award-number":["82071637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P\u2009&amp;lt;\u2009.05). In addition, the larger PA and shorter PL in the APE group than in the NPE and HC groups (P\u2009&amp;lt;\u2009.05). However, the electrophysiological parameters were not significantly different among the NPE, SPE, and HC groups (P\u2009&amp;gt;\u2009.05). In addition, PL &amp;lt;1262.0\u00a0milliseconds and DL &amp;lt;41.85 milliseconds were strong predictors of LPE, 1262.0\u00a0milliseconds\u2009&amp;lt;\u2009PL &amp;lt;1430.0\u00a0milliseconds was a predictor of APE, and PL &amp;gt;1430.0\u00a0milliseconds suggested possible SPE or NPE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical implications<\/jats:title>\n                  <jats:p>Analysis of the electrophysiological parameters of PE may be helpful for classification and treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>No previous study, to our knowledge, has analyzed the electrophysiological parameters of the four types of PE. The main limitation is the small sample size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>APE is characterized by increased sympathetic excitability, whereas LPE is characterized by increased penile sensitivity and increased sympathetic excitability. However, penile sensitivity and sympathetic excitability in SPE and NPE patients may not differ significantly from normal.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdae109","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:31:29Z","timestamp":1726050689000},"page":"1030-1036","source":"Crossref","is-referenced-by-count":6,"title":["The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation"],"prefix":"10.1093","volume":"21","author":[{"given":"Zhimin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Institute of Urology, Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation , Hefei 230022, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Institute of Urology, Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation , Hefei 230022, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Institute of Urology, Anhui Medical University , Hefei 230022, Anhui,","place":["China"]},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation , Hefei 230022, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"issue":"3","key":"2024110500213992500_ref1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.eururo.2006.07.004","article-title":"The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking","volume":"51","author":"Porst","year":"2007","journal-title":"Eur Urol"},{"issue":"2","key":"2024110500213992500_ref2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00926238908403817","article-title":"Premature ejaculation: clinical subgroups and etiology","volume":"15","author":"Godpodinoff","year":"1989","journal-title":"J Sex Marital Ther Summer"},{"issue":"6","key":"2024110500213992500_ref3","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/jsm.12524","article-title":"An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation","volume":"11","author":"Serefoglu","year":"2014","journal-title":"J Sex Med"},{"issue":"4","key":"2024110500213992500_ref4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1743-6109.2006.00276.x","article-title":"Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. 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