{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:02:01Z","timestamp":1789833721644,"version":"4.0.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To explore women\u2019s sexual functioning and associated quality of life after vaginal natural orifice transluminal endoscopic surgery (vNOTES) as an alternative to laparoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Two parallel group, 1:1 randomized single-centre single-blinded trials comparing the effects of vNOTES and laparoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Gynaecology unit of a Belgian teaching hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Population<\/jats:title>\n                  <jats:p>Women aged between 18 and 70\u00a0years with a benign indication for hysterectomy or adnexectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>After informed consent, women were randomized for vNOTES (experimental group) or laparoscopy (control group). Participants and outcome assessors were blinded. Paper and pencil questionnaires before surgery, as well as at 3 and 6\u00a0months after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The outcome of interest in this secondary analysis was sexual functioning at 3 and 6\u00a0months after surgery. We additionally measured quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 68 women allocated to the vNOTES (experimental) condition and 67 women allocated to the laparoscopy (control) condition. No significant effects of time, type of surgery, and surgical technique were found on patients\u2019 sexual function. At 3 and 6\u00a0months post-surgery, an increasing number of negative associations were found between quality of life and aspects of sexual functioning.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>vNOTES applied for hysterectomy and adnexectomy as compared to laparoscopy does not have a differential impact on women\u2019s sexual functioning. Sexual function has few links to patients\u2019 quality of life before surgery, but grows in relevance as a negative correlate of quality of life after surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf132","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T17:08:01Z","timestamp":1749920881000},"page":"1440-1446","source":"Crossref","is-referenced-by-count":4,"title":["Sexual functioning after vaginal natural orifice transluminal endoscopic surgery: combined results of two randomized controlled trials"],"prefix":"10.1093","volume":"22","author":[{"given":"Sofia","family":"Prekatsounaki","sequence":"first","affiliation":[{"name":"Institute for Family and Sexuality Studies KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J A","family":"Bosteels","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Imelda Hospital , Bonheiden ,","place":["Belgium"]},{"name":"Department of Uro-Gynaecology, Faculty of Medicine, University of Ghent , Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F","family":"Baekelandt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Imelda Hospital , Bonheiden ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben W J","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton Vic ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Enzlin","sequence":"additional","affiliation":[{"name":"Institute for Family and Sexuality Studies KU Leuven , Leuven 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