{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:00:38Z","timestamp":1789610438726,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Premature ejaculation (PE) is a prevalent sexual dysfunction with limited treatment options for some patients. Selective dorsal neurectomy\/cryoablation (SDN\/CA) has emerged as a potential treatment, aiming to desensitize the penis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the efficacy of SDN\/CA on intravaginal ejaculation latency time (IELT), PE-related questionnaires, treatment satisfaction, erectile function, and adverse events in the treatment of PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis were conducted, including randomized controlled trials, clinical trials, and prospective\/retrospective studies. Databases such as Embase, PubMed, Cochrane, and Web of Science were searched. The Cochrane risk-of-bias tool and Risk of Bias in Non-randomized Studies of Interventions-I tool were used for quality assessment. IELT (sec), questionnaires (Premature Ejaculation Diagnostic Tool, Premature Ejaculation Profile, Sexual Satisfaction Score), erectile status (IIEF [International Index of Erectile Function]-5), and adverse events were evaluated. Comprehensive meta-analysis and R software were used for statistical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies (235 patients) were included. SDN\/CA significantly improved IELT (mean difference: 147.47\u00a0sec, P\u2009&amp;lt;\u2009.05). Questionnaires showed improvements in sexual satisfaction and ejaculation control. No meaningful change was observed in the erectile function. The adverse event rate was 11.17%, with no significant difference between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SDN\/CA is controversial as a treatment option for PE, affecting IELT and patient satisfaction. The heterogeneity of the included studies and short-term follow-up periods shed light on further research. However, further research into standard protocols and longer follow-ups is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf140","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:41:55Z","timestamp":1748418115000},"page":"1383-1389","source":"Crossref","is-referenced-by-count":4,"title":["Clinical efficacy and safety of selective dorsal neurectomy\/cryoablation for treatment of premature ejaculation: systematic review and meta-analysis"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-2293","authenticated-orcid":false,"given":"Mehmet Gokhan","family":"Culha","sequence":"first","affiliation":[{"name":"Department of Urology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital , Sisli\/Istanbul, 34384 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