{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:45:15Z","timestamp":1787507115796,"version":"build-2736575974"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS), a prevalent endocrine disorder characterized by menstrual irregularities and hyperandrogenic manifestations, has been increasingly associated with psychological distress and impaired self-image. However, results regarding sexual function (SF) in PCOS women are still controversial, and their interpretation is complicated by the use of different SF assessment tools across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate female sexual dysfunction in PCOS women diagnosed through modified Rotterdam criteria by conducting specific meta-analyses for each validated SF questionnaire and assess the influence of overweight\/obesity (OW\/O) on these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Systematic Review (PRISMA) of 8 databases was performed until March 2024. Meta-analysis employed STATA software, employing a random-effects model to compare groups via Hedges\u2019 g and standardized mean difference (SMD). Heterogeneity (I2 statistic; Q test) and publication bias (funnel plots; Egger\u2019s test) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The influence of PCOS and OW\/O on SF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 6171 articles were initially screened, and 40\/6171 studies were included in this systematic review. Meta-analyses were performed solely for the Female Sexual Function Index (FSFI) score as it was the only SF assessment tool widely used across published studies. Pooled meta-analysis results showed that PCOS women had significantly lower FSFI scores in all fields than controls: total FSFI: -0.4 (95% CI -0.45; -0.36, I2\u00a0=\u200994.3%); desire: -0.22 (95% CI -0.26; -0.17, I2\u00a0=\u200990.8%); arousal: -0.3 (95% CI -0.34; -0.25, I2\u00a0=\u200994.1%); lubrication: -0.31 (95% CI -0.36; -0.26, I2\u00a0=\u200993%); orgasm: -0.27 (95% CI -0.32; -0.22 I2\u00a0=\u200989.2%); satisfaction: -0.23 (95% CI -0.28; -0.18, I2\u00a0=\u200981.5%); pain: -0.3 (95% CI -0.35; -0.25, I2\u00a0=\u200991.1%). OW\/O PCOS women scored with higher lubrication scores than OW\/O controls (SMD\u2009=\u20090.3 95% CI [0.03;0.58], P\u2009=\u2009.02, I2\u00a0=\u20090%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Translation<\/jats:title>\n                    <jats:p>These findings emphasize the importance of incorporating SF assessments into PCOS follow-up protocols and multidisciplinary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and Limitations<\/jats:title>\n                    <jats:p>Strengths include a large cohort, analysis of an OW\/O subgroup, and robust quality assessment using the Newcastle\u2013Ottawa Scale. The main limitation was the lack of published studies using SF-assessment tools other than the FSFI, which precluded meta-analyses for other questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While PCOS women experience significantly impaired SF than controls, those with OW\/O and PCOS may have comparable or even enhanced SF in certain domains, particularly lubrication, suggesting that the interplay between obesity and SF in PCOS women may not always be negative. By integrating routine screening with a multidisciplinary approach, we can more effectively address the sexual health challenges faced by PCOS women, ultimately empowering them to achieve optimal health and overall well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf163","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:46:43Z","timestamp":1753192003000},"page":"1612-1628","source":"Crossref","is-referenced-by-count":7,"title":["New comprehension on polycystic ovary syndrome and sexual function: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-7177","authenticated-orcid":false,"given":"Fernanda S","family":"Bachega","sequence":"first","affiliation":[{"name":"Disciplina de Ginecologia, Departamento de Obstetr\u00edcia e Ginecologia, Hospital das Cl\u00ednicas , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-921X","authenticated-orcid":false,"given":"Jos\u00e9 Ant\u00f4nio O","family":"Turri","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Departamento de Obstetr\u00edcia e Ginecologia, Hospital das Cl\u00ednicas , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-4045","authenticated-orcid":false,"given":"Maria C\u00e2ndida P","family":"Baracat","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia , , S\u00e3o Paulo ,","place":["Brazil"]},{"name":"Escola Paulista de Medicina\/ Universidade Federal de S\u00e3o Paulo , , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-0015","authenticated-orcid":false,"given":"Ricardo Santos","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Departamento de Obstetr\u00edcia e Ginecologia, Hospital das Cl\u00ednicas , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9097-8528","authenticated-orcid":false,"given":"Gustavo A R","family":"Maciel","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Departamento de Obstetr\u00edcia e Ginecologia, Hospital das Cl\u00ednicas , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1472-8313","authenticated-orcid":false,"given":"Roger A","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons , 622 West 168th Street, New York, NY 10032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-9404","authenticated-orcid":false,"suffix":"Jr","given":"Jos\u00e9 Maria","family":"Soares","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Departamento de Obstetr\u00edcia e Ginecologia, Hospital das Cl\u00ednicas , , 05466-040 S\u00e3o Paulo, SP ,","place":["Brazil"]},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP) , , 05466-040 S\u00e3o Paulo, SP 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