{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:37:44Z","timestamp":1791999464182,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Peyronie\u2019s disease leads to penile deformities and can cause physical symptoms, for example, penile pain, and erectile dysfunction, along with psychological issues, such as depressive symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this study was to investigate whether men with Peyronie\u2019s disease have an increased risk of depression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This nationwide cohort study included men with Peyronie\u2019s disease (ICD-10 code: N486) from 1997 to 2021 and age-matched (1:10) men without Peyronie\u2019s disease. We obtained complete medical history before the Peyronie\u2019s disease diagnosis\/index date. We followed both cohorts for depression. We computed the cumulative incidence of depression at 5 and 10\u00a0years of follow-up and estimated hazard ratios for depression comparing the 2 cohorts while adjusting for selected chronic diseases using Cox regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome<\/jats:title>\n                  <jats:p>The primary outcome, depression, was defined by ICD-10 code: F32, F33 recorded in the Danish National Patient Registry or the Psychiatric Central Research Registry and\/or redemption of at least 2 prescriptions for an antidepressant (ATC-code: N06A).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 10\u2009053 men with Peyronie\u2019s disease and 100\u2009530 without (median age 55.6\u00a0years). At the index date, 19.6% men with Peyronie\u2019s disease had depression versus 14.0% men without. At baseline, men with Peyronie\u2019s disease had a 5-year risk of depression of 7.0% versus 4.4% in men without, while the 10-year risks were 12.5% and 8.7%, respectively. The adjusted hazard ratio was 1.42 (95% CI, 1.32, 1.52).<\/jats:p>\n                  <jats:p>Men with Peyronie\u2019s disease had a 10-year all-cause mortality of 5.9%, while it was 9.1% in men without.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Health professionals should ensure that men with Peyronie\u2019s disease are examined for depression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>A limitation of our study is the potential underdiagnosis of men with Peyronie\u2019s disease, which may lead to an incorrect estimation of depression among Peyronie\u2019s disease patients. It is a strength that we include a nationwide cohort of men with Peyronie\u2019s disease and age-matched controls. Other strengths are that we included information from several Danish medical databases and depression was defined as a clinic diagnosis and\/or redemption of at least 2 prescriptions for an antidepressant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Men with Peyronie\u2019s disease had a higher prevalence of depression at the time of diagnosis and a higher risk of depression following diagnosis compared with men without.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf168","type":"journal-article","created":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T05:31:18Z","timestamp":1752989478000},"page":"1640-1646","source":"Crossref","is-referenced-by-count":2,"title":["Peyronie\u2019s disease and risk of depression. A nationwide 25-year cohort study"],"prefix":"10.1093","volume":"22","author":[{"given":"Sophie L\u00f8fvall","family":"Lindhardt-Mejlholm","sequence":"first","affiliation":[{"name":"Department of Urology, Odense University Hospital , 5000 Odense C,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7638-2322","authenticated-orcid":false,"given":"Katrine Schmidt","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Urology, Odense University Hospital , 5000 Odense C,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Trolle","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital , 8200 Aarhus N,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus 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