{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:35:33Z","timestamp":1783478133883,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-13-166-01"],"award-info":[{"award-number":["RSG-13-166-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Several studies have suggested a decrease in sexual function after risk-reducing salpingo-oophorectomy (RRSO) that is not mitigated by hormone therapy treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This is a prospective cohort study of women followed from the time of diagnosis, including those who chose whether to proceed with RRSO, and changes in sexual function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Premenopausal women were recruited from a high-risk cancer genetics clinic at a large academic center and completed detailed demographics and validated measures regarding their physical, mental, and sexual health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>Women were surveyed over the course of 60\u00a0months, using the Sexual Health Outcomes in Women Questionnaire (SHOW-Q), and results were analyzed, controlling for known confounders in sexual health, comparing women with and without RRSO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred women completed the study, 99 of whom completed baseline SHOW-Q surveys. Forty-one women planned RRSO at the beginning of the study, and another 30 underwent an RRSO during the study period. At baseline, women who underwent RRSO had lower sexual functioning scores in terms of sexual satisfaction and pelvic problem interface. Over 60\u00a0months, there was no difference in sexual function scores between the RRSO and the no-RRSO group in multivariable models that adjusted for depression, hormone use, menopausal symptoms, or other confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Pre-surgery sexual function predicts post-surgery sexual function, which challenges existing dogma, and women can be reassured that surgery likely won\u2019t affect sexual function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>This study\u2019s strength was the relatively large sample size and long-term follow-up. Limitations were a relatively homogeneous population that may not reflect the diversity of patient experiences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings can be useful to providers and patients in understanding the effects of surgery and are reassuring that sexual function may, in fact, not be worsened by surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf183","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:16:36Z","timestamp":1752502596000},"page":"1606-1611","source":"Crossref","is-referenced-by-count":2,"title":["Sexual functioning after risk-reducing oophorectomy: a prospective study"],"prefix":"10.1093","volume":"22","author":[{"given":"Tami S","family":"Rowen","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco , San Francisco 94158, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco , San Francisco 94158, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-May","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco , San Francisco 94158, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco , San Francisco 94158, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Jacoby","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco , San Francisco 94158, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"3","key":"2025090408013584400_ref1","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1097\/AOG.0000000000002296","article-title":"Practice bulletin No 182: hereditary breast and ovarian cancer syndrome","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"21","key":"2025090408013584400_ref2","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa020119","article-title":"Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation","volume":"346","author":"Kauff","year":"2002","journal-title":"N Engl J Med"},{"issue":"5","key":"2025090408013584400_ref3","doi-asserted-by":"publisher","first-page":"508.e1","DOI":"10.1016\/j.ajog.2021.06.070","article-title":"Uptake and timing of risk-reducing salpingo-oophorectomy among patients with BRCA1 and BRCA2 mutations","volume":"225","author":"Smith","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"2025090408013584400_ref4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S1701-2163(16)35160-X","article-title":"Risk-reducing bilateral salpingo-oophorectomy and sexual health: a qualitative study","volume":"34","author":"Brotto","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"issue":"5","key":"2025090408013584400_ref5","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1097\/AOG.0b013e3181898cdb","article-title":"Sexual problems and distress in United States women: prevalence and correlates","volume":"112","author":"Shifren","year":"2008","journal-title":"Obstet Gynecol"},{"issue":"12","key":"2025090408013584400_ref6","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.jsxm.2022.08.191","article-title":"Surgical menopause and bilateral oophorectomy: effect of estrogen-progesterone and testosterone replacement therapy on psychological well-being and sexual functioning; 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