{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:17:14Z","timestamp":1759709834292,"version":"build-2065373602"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Multiple guideline-based surgical treatment options for Peyronie\u2019s disease (PD) exist, including penile plication and plaque incision or excision and grafting. Surgical incision type may differ depending upon location and severity of curve, planned concomitant procedures, and surgeon preference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate postoperative wound complications comparing outcomes between ventral and subcoronal incisions in patients undergoing tunica albuginea plication (TAP) and plaque incision or partial excision and grafting (PG) for PD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A single-surgeon, single-center retrospective chart review was conducted on all patients undergoing TAP or PG from 2019 to 2023. Patient demographics, including previous PD treatments, were recorded. A Mann\u2013Whitney U test was utilized to determine differences in wound complication rate, median curvature improvement, and remaining postoperative curvature between ventral and subcoronal approaches.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>Wound complication was classified as any dehiscence and\/or wound exudate suspicious for infection within the first 3\u00a0months postoperatively. A secondary analysis was performed comparing these outcomes between TAP and PG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the analysis, 189 patients were included, including PD straightening surgery, including 125 patients who underwent TAP (66%) and 64 patients (34%) who underwent PG. Among all cases, 49.7% underwent ventral incision (N\u2009=\u200994) and 50.3% (N\u2009=\u200995) underwent subcoronal incision. A total of 12 patients (6.3%) experienced a wound-related complication postoperatively (range 3-23\u00a0days), including 9\/94 (9.6%) in the ventral incision cohort and 3\/95 (3.2%) in the subcoronal cohort (P\u2009=\u20090.081). All the patients were treated with oral antibiotics and two patients required closure under local anesthesia (both in the ventral incision cohort). Secondary analysis did not reveal any significant difference in outcomes between TAP and PG cohorts with respect to wound complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>While we did not identify a statistically significant difference, most of our wound complications, including infection and\/or dehiscence, were seen in those undergoing a ventral penile raphe incision. Despite this, the rate of wound complications with either incisional approach as low.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>Our report represents a large cohort of patients treated with surgical straightening for PD, and to our knowledge is one of the first to compare wound complications between ventral and subcoronal incisions. Limitations include the retrospective single-surgeon series without randomization, lack of power analysis, and heterogenous classification of wound complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Both ventral penile raphe and subcoronal (degloving) incisions can be considered for penile straightening procedures to correct PD curvature deformity with a low risk for serious wound-related complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf189","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T04:57:22Z","timestamp":1756097842000},"page":"1863-1870","source":"Crossref","is-referenced-by-count":0,"title":["What is the right approach for Peyronie\u2019s disease surgery? Comparing postoperative wound complications between ventral and subcoronal incisions with penile straightening surgery"],"prefix":"10.1093","volume":"22","author":[{"given":"Amanda","family":"Seyer","sequence":"first","affiliation":[{"name":"Department of Urology, Mayo Clinic , Rochester, MN 55905 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Piraino","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic , Rochester, MN 55905 ,","place":["United States"]},{"name":"Carolina Urology Partners , Charlotte, NC 28210 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7186-164X","authenticated-orcid":false,"given":"Andres Guillen","family":"Lozoya","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic , Rochester, MN 55905 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Ziegelmann","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic , Rochester, MN 55905 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"issue":"4","key":"2025100504572854900_ref1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.sxmr.2019.02.004","article-title":"Pathophysiology and future therapeutic perspectives for resolving fibrosis in Peyronie\u2019s disease","volume":"7","author":"Milenkovic","year":"2019","journal-title":"Sex Med Rev"},{"issue":"3","key":"2025100504572854900_ref2","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1743-6109.2012.02999.x","article-title":"Psychological impact of Peyronie\u2019s disease: a review","volume":"10","author":"Nelson","year":"2013","journal-title":"J Sex Med"},{"issue":"3","key":"2025100504572854900_ref3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.juro.2015.05.098","article-title":"Peyronie\u2019s disease: AUA guideline","volume":"194","author":"Nehra","year":"2015","journal-title":"J Urol"},{"issue":"4","key":"2025100504572854900_ref4","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/S0022-5347(17)37988-0","article-title":"The incidence of Peyronie\u2019s disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J Urol"},{"issue":"6 Part 1","key":"2025100504572854900_ref5","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1097\/01.ju.0000127744.18878.f1","article-title":"Subjective and objective analysis of the prevalence of Peyronie\u2019s disease in a population of men presenting for prostate cancer screening","volume":"171","author":"Mulhall","year":"2004","journal-title":"J Urol"},{"issue":"2","key":"2025100504572854900_ref6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.sxmr.2019.06.004","article-title":"The etiology of Peyronie\u2019s disease: pathogenesis and genetic contributions","volume":"8","author":"Sharma","year":"2020","journal-title":"Sex Med Rev"},{"issue":"7","key":"2025100504572854900_ref7","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie\u2019s disease: results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"issue":"3","key":"2025100504572854900_ref8","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1743-6109.2009.01655.x","article-title":"Peyronie\u2019s disease following radical prostatectomy: incidence and predictors","volume":"7","author":"Tal","year":"2010","journal-title":"J Sex Med"},{"issue":"5 Part 1","key":"2025100504572854900_ref9","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/S0022-5347(17)35816-0","article-title":"The incidence of congenital penile curvature","volume":"150","author":"Yachia","year":"1993","journal-title":"J Urol"},{"issue":"2356-6140","key":"2025100504572854900_ref10","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1100\/tsw.2011.136","article-title":"Abnormalities of penile curvature: chordee and penile torsion","volume":"11","author":"Montag","year":"2011","journal-title":"ScientificWorldJournal."},{"issue":"4","key":"2025100504572854900_ref11","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s11934-012-0257-x","article-title":"Congenital penile curvature: update and management","volume":"13","author":"Makovey","year":"2012","journal-title":"Curr Urol Rep"},{"issue":"5","key":"2025100504572854900_ref12","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1080\/13685538.2019.1586870","article-title":"Supporting the role of penile trauma and micro-trauma in the etiology of Peyronie\u2019s disease. Prospective observational study using the electronic microscope to examine two types of plaques","volume":"23","author":"De Rose","year":"2020","journal-title":"Aging Male"},{"issue":"6","key":"2025100504572854900_ref13","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1016\/j.juro.2008.01.093","article-title":"Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleukin-1beta and transforming growth factor-beta in Peyronie\u2019s plaque fibroblasts","volume":"179","author":"Del Carlo","year":"2008","journal-title":"J Urol"},{"issue":"4","key":"2025100504572854900_ref14","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/S0022-5347(01)64223-X","article-title":"Peyronie\u2019s disease is associated with an increase in transforming growth factor-beta protein expression","volume":"158","author":"El-Sakka","year":"1997","journal-title":"J Urol"},{"issue":"9","key":"2025100504572854900_ref15","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1046\/j.1464-410X.2003.04224.x","article-title":"Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie\u2019s disease","volume":"91","author":"Davila","year":"2003","journal-title":"BJU Int"},{"issue":"5","key":"2025100504572854900_ref16","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.5489\/cuaj.5255","article-title":"2018 Canadian Urological Association guideline for Peyronie\u2019s disease and congenital penile curvature","volume":"12","author":"Bella","year":"2018","journal-title":"Can Urol Assoc J"},{"issue":"2","key":"2025100504572854900_ref17","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jsxm.2020.11.013","article-title":"Comparing and contrasting Peyronie\u2019s disease guidelines: points of consensus and deviation","volume":"18","author":"Manka","year":"2021","journal-title":"J Sex Med"},{"issue":"6","key":"2025100504572854900_ref18","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.jsxm.2016.04.062","article-title":"Evidence-based management guidelines on Peyronie\u2019s disease","volume":"13","author":"Chung","year":"2016","journal-title":"J Sex Med"},{"issue":"3","key":"2025100504572854900_ref19","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ucl.2022.04.006","article-title":"Complex penile surgery: plication, grafting, and implants","volume":"49","author":"Lee","year":"2022","journal-title":"Urol Clin North Am"},{"issue":"6","key":"2025100504572854900_ref20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/1756287212448224","article-title":"Update on plication procedures for Peyronie\u2019s disease and other penile deformities","volume":"4","author":"Mobley","year":"2012","journal-title":"Ther Adv Urol"},{"key":"2025100504572854900_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2022.03.005","article-title":"Penile plication for Peyronie\u2019s disease: the iterative 8-dot technique","volume":"164","author":"Demzik","year":"2022","journal-title":"Urology"},{"issue":"1","key":"2025100504572854900_ref22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0022-5347(05)00063-7","article-title":"Factors affecting the loss of length associated with tunica albuginea plication for correction of penile curvature","volume":"175","author":"Greenfield","year":"2006","journal-title":"J Urol"},{"issue":"S6","key":"2025100504572854900_ref23","doi-asserted-by":"publisher","first-page":"63s","DOI":"10.1002\/j.1939-4640.1994.tb01709.x","article-title":"Our experience with penile deformations: incidence, operative techniques, and results","volume":"15","author":"Yachia","year":"1994","journal-title":"J Androl"},{"issue":"6","key":"2025100504572854900_ref24","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/0090-4295(85)90285-7","article-title":"New surgical treatment for Peyronie disease","volume":"25","author":"Essed","year":"1985","journal-title":"Urology"},{"issue":"6","key":"2025100504572854900_ref25","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/S0022-5347(17)35341-7","article-title":"Dorsal tunica albuginea plication for hypospadias curvature","volume":"151","author":"Baskin","year":"1994","journal-title":"J Urol"},{"issue":"4","key":"2025100504572854900_ref26","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.urology.2011.12.036","article-title":"Penile plication without degloving enables effective correction of complex Peyronie\u2019s deformities","volume":"79","author":"Adibi","year":"2012","journal-title":"Urology"},{"issue":"2","key":"2025100504572854900_ref27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1743-6109.2007.00429.x","article-title":"Surgical techniques: 16-dot procedure for penile curvature","volume":"4","author":"Brant","year":"2007","journal-title":"J Sex Med"},{"issue":"6","key":"2025100504572854900_ref28","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1111\/jsm.12910","article-title":"Examining postoperative outcomes after employing a surgical algorithm for management of Peyronie\u2019s disease: a single-institution retrospective review","volume":"12","author":"Papagiannopoulos","year":"2015","journal-title":"J Sex Med"},{"issue":"1","key":"2025100504572854900_ref29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/andr.12421","article-title":"Grafts for Peyronie\u2019s disease: a comprehensive review","volume":"6","author":"Garcia-Gomez","year":"2018","journal-title":"Andrology"},{"issue":"10","key":"2025100504572854900_ref30","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1111\/j.1464-410X.2009.08991.x","article-title":"Penoscrotal plication as a uniform approach to reconstruction of penile curvature","volume":"105","author":"Dugi","year":"2010","journal-title":"BJU Int"},{"issue":"6","key":"2025100504572854900_ref31","doi-asserted-by":"publisher","first-page":"100462","DOI":"10.1016\/j.esxm.2021.100462","article-title":"Plication for correction of congenital penile curvature: with or without degloving?","volume":"9","author":"Kusin","year":"2021","journal-title":"Sex Med"},{"issue":"0169-409X","key":"2025100504572854900_ref32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.addr.2014.12.002","article-title":"Wound healing in urology","volume":"82\u201383","author":"Ninan","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"2025100504572854900_ref33","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.jsxm.2018.07.003","article-title":"Penile size restoration with nondegloving approach for Peyronie\u2019s disease: initial experience","volume":"15","author":"Clavell-Hern\u00e1ndez","year":"2018","journal-title":"J Sex Med"},{"issue":"3","key":"2025100504572854900_ref34","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.juro.2012.09.085","article-title":"Favorable patient reported outcomes after penile plication for wide array of Peyronie disease abnormalities","volume":"189","author":"Hudak","year":"2013","journal-title":"J Urol"},{"issue":"4","key":"2025100504572854900_ref35","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/JU.0000000000003619","article-title":"Subcoronal incision for inflatable penile prosthesis does not risk glans necrosis","volume":"210","author":"Park","year":"2023","journal-title":"J Urol"},{"issue":"0090-4295","key":"2025100504572854900_ref36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.urology.2017.06.020","article-title":"Glans necrosis following penile prosthesis implantation: prevention and treatment suggestions","volume":"107","author":"Wilson","year":"2017","journal-title":"Urology"},{"issue":"3","key":"2025100504572854900_ref37","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/S0022-5347(17)38872-9","article-title":"Peyronie\u2019s disease: surgical experience and presentation of a proximal approach","volume":"142","author":"Cohen","year":"1989","journal-title":"J Urol"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/22\/10\/1863\/64116055\/qdaf189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/22\/10\/1863\/64116055\/qdaf189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T08:57:34Z","timestamp":1759654654000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/22\/10\/1863\/8240470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,8,25]]},"published-print":{"date-parts":[[2025,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdaf189","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"type":"print","value":"1743-6095"},{"type":"electronic","value":"1743-6109"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,8,25]]}}}