{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:33:44Z","timestamp":1792028024292,"version":"4.4.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recent research has highlighted the potential advantages of combining pharmacologic and non-pharmacologic approaches in treating lifelong premature ejaculation (LPE). Individual therapies have demonstrated efficacy but there is a lack of comprehensive analysis comparing combined treatments to pharmacologic monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the combined effect of dapoxetine with non-pharmacological therapies compared to drug monotherapy in improving ejaculatory latency, functionality, and self-perception of sexual dysfunction in individuals with LPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed in PubMed, PEDro, Cochrane, Web of Science, CINAHL, and Academic Search Ultimate databases from inception to October 2024 to identify randomized controlled trials (RCTs). The primary outcome was the intravaginal ejaculatory latency time (IELT), while secondary outcomes were self-perception improvements, assessed using the Premature Ejaculation Diagnostic Tool (PEDT), the premature ejaculation profile (PEP), and other evaluation instruments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight RCTs (n\u2009=\u2009656 participants) were included. Pooled analysis of studies showed a significant effect of dapoxetine combined with non-pharmacological therapies in improving IELT compared to dapoxetine monotherapy (SDM\u2009=\u20091.6; 95%CI, 0.5-2.8; P\u2009=\u2009.01), PEDT scores (SDM\u2009=\u20090.9; 95%CI, 0.4-1.4; P\u2009&amp;lt;\u2009.001) and PEP subscales, with moderate certainty of evidence according to the GRADE guidelines. The non-pharmacological therapies included shockwave therapy, biofeedback, electric stimulation, pelvic floor muscle training, desensitization techniques, psychotherapy, and behavioral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis indicate that while dapoxetine is recognized for its beneficial effects, its clinical efficacy is significantly enhanced when combined with non-pharmacological interventions. Combination therapy increases IELT, reduces PEDT scores, and improves PEP scores. These findings suggest that combination therapy is more effective than dapoxetine monotherapy in improving functional outcomes and self-perception in patients with LPE, supported by moderate certainty of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf238","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T11:43:36Z","timestamp":1756640616000},"page":"1948-1957","source":"Crossref","is-referenced-by-count":4,"title":["Dapoxetine combined with non-pharmacological approaches for lifelong premature ejaculation. A systematic review and meta-analysis"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7124-4589","authenticated-orcid":false,"given":"Marta","family":"Nieves Mart\u00edn","sequence":"first","affiliation":[{"name":"Woman & Health Research Group, Department of Physiotherapy, Faculty of Medicine, Health and Sports, European University of Madrid , Madrid 28670 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mar\u00edn Novoa","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Pedro , Logro\u00f1o , 26006,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Avenda\u00f1o-Coy","sequence":"additional","affiliation":[{"name":"Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursery, Universidad de Castilla-La Mancha , Toledo 45071 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"2025110819151831700_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jsxmed\/qdae001.292","article-title":"Prevalence of sexual dysfunction and pursuit of sexual medicine evaluation among male physicians\u2014a survey","volume":"21","author":"Lin","year":"2024","journal-title":"Int J Impot Res"},{"issue":"2","key":"2025110819151831700_ref2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/sm2.27","article-title":"An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation","volume":"2","author":"Serefoglu","year":"2014","journal-title":"Sex Med"},{"key":"2025110819151831700_ref3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association"},{"issue":"6","key":"2025110819151831700_ref4","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1111\/jsm.12504","article-title":"An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE)","volume":"11","author":"Althof","year":"2014","journal-title":"J Sex Med"},{"key":"2025110819151831700_ref5","doi-asserted-by":"publisher","volume-title":"Premature Ejaculation","author":"Waldinger","DOI":"10.1007\/978-88-470-2646-9_6"},{"key":"2025110819151831700_ref6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s11930-019-00232-9","article-title":"Premature ejaculation: 2020 update","volume":"11","author":"Russo","year":"2019","journal-title":"Curr Sex Health Rep"},{"issue":"3","key":"2025110819151831700_ref7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5152\/alphapsychiatry.2022.21630","article-title":"Lifelong premature ejaculation and attention-deficit hyperactivity disorder: a controlled study","volume":"23","author":"Ayan","year":"2022","journal-title":"Alpha Psychiatry"},{"issue":"3","key":"2025110819151831700_ref8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/2090598X.2021.1943273","article-title":"An update on the treatment of premature ejaculation: a systematic review","volume":"19","author":"Saleh","year":"2021","journal-title":"Arab J Urol"},{"issue":"1","key":"2025110819151831700_ref9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/iju.13202","article-title":"Current and emerging therapies in premature ejaculation: where we are coming from, where we are going","volume":"24","author":"Martin","year":"2017","journal-title":"Int J Urol"},{"issue":"8","key":"2025110819151831700_ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42913","article-title":"Topical anesthetics and premature ejaculation: a systematic review and meta-analysis","volume":"15","author":"Shah","journal-title":"Cureus"},{"issue":"2","key":"2025110819151831700_ref11","doi-asserted-by":"publisher","first-page":"338","DOI":"10.5534\/wjmh.230030","article-title":"Efficacy of various treatment in premature ejaculation: systematic review and network meta-analysis","volume":"42","author":"Lee","year":"2024","journal-title":"World J Men's Health"},{"issue":"8","key":"2025110819151831700_ref12","doi-asserted-by":"publisher","first-page":"e14500","DOI":"10.1111\/and.14500","article-title":"Comparison of fluoxetine with other selective serotonin reuptake inhibitors in the treatment of premature ejaculation: a systematic review and meta-analysis","volume":"54","author":"Liu","year":"2022","journal-title":"Andrologia."},{"issue":"5","key":"2025110819151831700_ref13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.5144\/0256-4947.2018.366","article-title":"Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis","volume":"38","author":"Li","year":"2018","journal-title":"Ann Saudi Med"},{"issue":"2","key":"2025110819151831700_ref14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/tre.903","article-title":"Non-pharmacological approaches for treatment of premature ejaculation: a systematic review","volume":"14","author":"Pizzol","year":"2023","journal-title":"Trends Urol Men's Health"},{"issue":"3","key":"2025110819151831700_ref15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/1756287214523329","article-title":"Pelvic floor muscle rehabilitation for patients with lifelong premature ejaculation: a novel therapeutic approach","volume":"6","author":"Pastore","year":"2014","journal-title":"Ther Adv Urol"},{"issue":"6","key":"2025110819151831700_ref16","doi-asserted-by":"publisher","first-page":"572","DOI":"10.4103\/aja.aja_30_18","article-title":"Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: long-term outcomes","volume":"20","author":"Pastore","year":"2018","journal-title":"Asian J Androl"},{"issue":"2","key":"2025110819151831700_ref17","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4081\/aiua.2014.2.123","article-title":"Awareness and timing of pelvic floor muscle contraction, pelvic exercises and rehabilitation of pelvic floor in lifelong premature ejaculation: 5 years experience","volume":"86","author":"La Pera","year":"2014","journal-title":"Arch Ital Urol Androl"},{"issue":"4","key":"2025110819151831700_ref18","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/j.1365-2605.2011.01243.x","article-title":"A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation","volume":"35","author":"Pastore","year":"2012","journal-title":"Int J Androl"},{"issue":"2","key":"2025110819151831700_ref19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.physio.2019.01.002","article-title":"Pelvic floor muscle training improves erectile dysfunction and premature ejaculation: a systematic review","volume":"105","author":"Myers","year":"2019","journal-title":"Physiotherapy."},{"key":"2025110819151831700_ref20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/1110-161X.155649","article-title":"Treatment of premature ejaculation: a new combined approach","volume":"42","author":"Kurkar","year":"2015","journal-title":"Egypt Rheumatol Rehabil"},{"issue":"1","key":"2025110819151831700_ref21","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.esxm.2016.08.002","article-title":"Complementary and alternative medicine for management of premature ejaculation: a systematic review","volume":"5","author":"Cooper","year":"2017","journal-title":"Sex Med."},{"issue":"3","key":"2025110819151831700_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfad034","article-title":"Acupuncture for premature ejaculation: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2023","journal-title":"Sex Med"},{"issue":"2","key":"2025110819151831700_ref23","doi-asserted-by":"publisher","first-page":"e0212274","DOI":"10.1371\/journal.pone.0212274","article-title":"Efficacy of sphincter control training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: a parallel-group randomized, controlled trial","volume":"14","author":"Rodr\u00edguez","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"2025110819151831700_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008195.pub2","article-title":"Psychosocial interventions for premature ejaculation","volume":"2011","author":"Melnik","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2025110819151831700_ref25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.aju.2013.04.011","article-title":"Integrating psychotherapy and pharmacotherapy in the treatment of premature ejaculation","volume":"11","author":"Ciocca","year":"2013","journal-title":"Arab J Urol"},{"key":"2025110819151831700_ref26","doi-asserted-by":"publisher","first-page":"631","DOI":"10.4103\/aja.aja_34_19","article-title":"Regular penis-root masturbation, a novel behavioral therapy in the treatment of primary premature ejaculation","volume":"21","author":"Ma","year":"2019","journal-title":"Asian J Androl."},{"issue":"15-16","key":"2025110819151831700_ref27","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.purol.2023.09.010","article-title":"Regular penis-root masturbation: a promising behavioral treatment method for lifelong premature ejaculation","volume":"33","author":"Memik","year":"2023","journal-title":"Prog Urol"},{"issue":"9","key":"2025110819151831700_ref28","doi-asserted-by":"publisher","first-page":"e0257284","DOI":"10.1371\/journal.pone.0257284","article-title":"Efficacy of sphincter control training and medical device in the treatment of premature ejaculation: a multicenter randomized controlled clinical trial","volume":"16","author":"Rodr\u00edguez","year":"2021","journal-title":"PLoS One"},{"issue":"5","key":"2025110819151831700_ref29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.18621\/eurj.565190","article-title":"The impact of transcutaneous posterior tibial nerve stimulation in patients with premature ejaculation","volume":"6","author":"Aydos","year":"2020","journal-title":"Eur Res J"},{"issue":"4","key":"2025110819151831700_ref30","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41443-019-0196-x","article-title":"Transcutaneous electric nerve stimulation to treat patients with premature ejaculation: phase II clinical trial","volume":"32","author":"Uribe","year":"2020","journal-title":"Int J Impot Res"},{"issue":"1","key":"2025110819151831700_ref31","doi-asserted-by":"publisher","first-page":"e12799","DOI":"10.1111\/and.12799","article-title":"Impact of physical activity on patient self-reported outcomes of lifelong premature ejaculation patients: results of a prospective, randomised, sham-controlled trial","volume":"50","author":"Kilinc","year":"2018","journal-title":"Andrologia."},{"issue":"1","key":"2025110819151831700_ref32","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000445253","article-title":"A prospective randomized controlled study to compare acupuncture and dapoxetine for the treatment of premature ejaculation","volume":"97","author":"Sahin","year":"2016","journal-title":"Urol Int"},{"key":"2025110819151831700_ref33","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Jpt","year":"2008"},{"key":"2025110819151831700_ref34","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ."},{"issue":"4","key":"2025110819151831700_ref35","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/j.1743-6109.2005.00070.x","article-title":"A multinational population survey of intravaginal ejaculation latency time","volume":"2","author":"Waldinger","year":"2005","journal-title":"J Sex Med"},{"issue":"2","key":"2025110819151831700_ref36","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/j.1743-6109.2007.00696.x","article-title":"Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy","volume":"5","author":"Waldinger","year":"2008","journal-title":"J Sex Med"},{"issue":"4","key":"2025110819151831700_ref37","doi-asserted-by":"publisher","first-page":"470","DOI":"10.21037\/tau.2016.05.04","article-title":"Patient reported outcomes in the assessment of premature ejaculation","volume":"5","author":"Althof","year":"2016","journal-title":"Transl Androl Urol"},{"issue":"4","key":"2025110819151831700_ref38","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jsxm.2019.01.311","article-title":"Content validity of the premature ejaculation profile, original and per-event formats, in men with lifelong premature ejaculation","volume":"16","author":"Burbridge","year":"2019","journal-title":"J Sex Med"},{"key":"2025110819151831700_ref39","first-page":"38","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.0","author":"Higgins","year":"2011"},{"issue":"2","key":"2025110819151831700_ref40","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"4","key":"2025110819151831700_ref41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction\u2014GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"2025110819151831700_ref42","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","edition":"2nd ed"},{"issue":"7414","key":"2025110819151831700_ref43","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ."},{"key":"2025110819151831700_ref44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jclinepi.2022.10.003","article-title":"In a meta-analysis, the I-squared statistic does not tell us how much the effect size varies","volume":"152","author":"Borenstein","year":"2022","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"2025110819151831700_ref45","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1464-410X.2008.08041.x","article-title":"The premature ejaculation profile: validation of self-reported outcome measures for research and practice","volume":"103","author":"Patrick","year":"2009","journal-title":"BJU Int"},{"issue":"7","key":"2025110819151831700_ref46","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1111\/jsm.12925","article-title":"The combination of dapoxetine and behavioral treatment provides better results than dapoxetine alone in the management of patients with lifelong premature ejaculation","volume":"12","author":"Cormio","year":"2015","journal-title":"J Sex Med"},{"issue":"4","key":"2025110819151831700_ref47","doi-asserted-by":"publisher","first-page":"e13135","DOI":"10.1111\/and.13135","article-title":"Effect of premature ejaculation desensitisation therapy combined with dapoxetine hydrochloride on the treatment of primary premature ejaculation","volume":"51","author":"Fu","year":"2019","journal-title":"Andrologia."},{"issue":"7","key":"2025110819151831700_ref48","first-page":"611","article-title":"Priligy combined with behavioral therapy and psychological counseling for primary premature ejaculation","volume":"26","author":"Cai","year":"2020","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"8","key":"2025110819151831700_ref49","first-page":"92","article-title":"A randomized controlled trial of combined low-intensity extracorporeal shockwave therapy and dapoxetine use in the management of lifelong premature ejaculation","volume":"19","author":"Dogan","year":"2023","journal-title":"J Men's Health"},{"issue":"11","key":"2025110819151831700_ref50","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1007\/s11255-022-03338-7","article-title":"Efficacy of combination therapy with biofeedback and dapoxetine in lifelong premature ejaculation treatment: a prospective randomized study","volume":"54","author":"Y\u0131lmaz","year":"2022","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"2025110819151831700_ref51","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4081\/aiua.2017.2.114","article-title":"Premature ejaculation: pharmacotherapy vs group psychotherapy alone or in combination","volume":"89","author":"Pavone","year":"2017","journal-title":"Ital Arch Urol Androl"},{"issue":"2","key":"2025110819151831700_ref52","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4081\/aiua.2017.2.148","article-title":"Pharmacological\/dynamic rehabilitative behavioural therapy for premature ejaculation: results of a pilot study","volume":"89","author":"Mantovani","year":"2017","journal-title":"Arch Ital Urol Androl"},{"issue":"9","key":"2025110819151831700_ref53","first-page":"815","article-title":"Clinical observation of dapoxetine combined with percutaneous neuromuscular electrical stimulation in the treatment of primary premature ejaculation","volume":"29","author":"Xu","year":"2023","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"2","key":"2025110819151831700_ref54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1569-9056(10)60313-2","article-title":"Clinical global impression of change (CGIC): predictors and correlates following treatment in men with premature ejaculation (PE)","volume":"9","author":"Rowland","year":"2010","journal-title":"Eur Urol Suppl"},{"issue":"6","key":"2025110819151831700_ref55","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1111\/j.1743-6109.2010.01793.x","article-title":"Validity of the patient-reported clinical global impression of change as a measure of treatment response in men with premature ejaculation","volume":"7","author":"Althof","year":"2010","journal-title":"J Sex Med"},{"key":"2025110819151831700_ref56","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfac012","article-title":"Clinical value of penile sympathetic skin response to assess the efficacy of sertraline in the treatment of patients with sympathetic hyperexcitability in primary premature ejaculation","volume":"11","author":"Li","year":"2023","journal-title":"Sex Med."},{"issue":"2","key":"2025110819151831700_ref57","first-page":"101","article-title":"Clinical validation of an anxiety and depression screening test for intensive in-hospital rehabilitation","volume":"58","author":"Vedana","year":"2002","journal-title":"Monaldi Arch Chest Dis"},{"issue":"3","key":"2025110819151831700_ref58","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MLR.0b013e318160d093","article-title":"Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population","volume":"46","author":"L\u00f6we","year":"2008","journal-title":"Med Care"},{"key":"2025110819151831700_ref59","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jad.2020.09.131","article-title":"Screening for depression in primary care with patient health Questionnaire-9 (PHQ-9): a systematic review","volume":"279","author":"Costantini","year":"2021","journal-title":"J Affect Disord"},{"issue":"4","key":"2025110819151831700_ref60","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.urology.2015.01.009","article-title":"Efficacy of dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events","volume":"85","author":"Yue","year":"2015","journal-title":"Urology."},{"issue":"7","key":"2025110819151831700_ref61","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/j.1464-410X.2008.07845.x","article-title":"Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine","volume":"102","author":"Shabsigh","year":"2008","journal-title":"BJU Int"},{"key":"2025110819151831700_ref62","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/s41443-024-00875-w","article-title":"New technologies developed for treatment of premature ejaculation","volume":"36","author":"Shechter","year":"2024","journal-title":"Int J Impot Res"},{"issue":"1","key":"2025110819151831700_ref63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00926230701640355","article-title":"Premature ejaculation: different pathophysiologies and etiologies determine its treatment","volume":"34","author":"Waldinger","year":"2007","journal-title":"J Sex Marital Ther"},{"issue":"6","key":"2025110819151831700_ref64","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s40618-023-02015-5","article-title":"The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian scientific societies, guidelines on the diagnosis and management of erectile dysfunction","volume":"46","author":"Corona","year":"2023","journal-title":"J Endocrinol Investig"},{"issue":"7","key":"2025110819151831700_ref65","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1111\/jsm.12180","article-title":"Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: a large observational study in China","volume":"10","author":"Gao","year":"2013","journal-title":"J Sex Med"},{"key":"2025110819151831700_ref66","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1590\/s1677-5538.ibju.2020.04.11","article-title":"Editorial comment: erectile dysfunction and premature ejaculation in homosexual and heterosexual men: a systematic review and meta-analysis of comparative studies","volume":"46","author":"Javaroni","year":"2020","journal-title":"Int Braz J Urol"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/22\/11\/1948\/64426434\/qdaf238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/22\/11\/1948\/64426434\/qdaf238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:15:22Z","timestamp":1762647322000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/22\/11\/1948\/8267781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":66,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,9,29]]},"published-print":{"date-parts":[[2025,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdaf238","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"value":"1743-6095","type":"print"},{"value":"1743-6109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,9,29]]}}}