{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:39:50Z","timestamp":1767623990966,"version":"3.48.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary premature ejaculation (PPE) is a common lifelong sexual disorder that adversely affects sexual satisfaction and quality of life (QoL), and current treatments have limitations in efficacy, tolerability, or durability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy, safety, and feasibility of sacral nerve root magnetic stimulation (SNRMS) vs sham in men with PPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From July 2023 to September 2024, we conducted a prospective, single-blind, randomized, sham-controlled trial. Fifty-three men meeting ISSM criteria for PPE (age 18-65, stable sexual relationship) were randomized 1:1. Active stimulation used a Magneuro60F coil positioned over S2-S4. Sham delivered identical coil placement and initial low-intensity pulse but no therapeutic output thereafter. Randomization used computer-generated permuted blocks with allocation concealment by sealed envelopes; patients were blinded, and outcome assessors\/statisticians remained masked. Analyses used intention-to-treat principles; continuous outcomes reported as mean\u2009\u00b1\u2009SD with 95% CI and Cohen\u2019s d; categorical outcomes compared with Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>Primary outcome was change in intravaginal ejaculatory latency time (IELT) measured by stopwatch at 6\u00a0months after treatment completion; treatment success defined as IELT \u226590\u00a0s at 6\u00a0months. Secondary outcomes included Premature Ejaculation Profile (PEP), sexual satisfaction (5-point Likert), International Index of Erectile Function (IIEF-5), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), SF-12 QoL, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 6\u00a0months, mean IELT increased from 37.4\u2009\u00b1\u200913.7 to 92.1\u2009\u00b1\u200946.4\u00a0s in the SNRMS group (mean change 54.7\u00a0s; 95% CI, 38.2-71.1; Cohen\u2019s d\u2009=\u20091.37). Treatment success (IELT \u226590\u00a0s) occurred in 33.3% (9\/27) of SNRMS participants. PEP, sexual satisfaction, SAS, SDS, and SF-12 mental scores improved significantly more with SNRMS (all P\u2009&amp;lt;\u2009.01). Adverse events were mild and transient; no serious adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>Sacral nerve root magnetic stimulation is a promising non-invasive therapy that can substantially prolong IELT and improve sexual and psychological outcomes in men with PPE, potentially offering a durable alternative to daily pharmacotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and Limitations<\/jats:title>\n                    <jats:p>Strengths include prospective randomized sham-control, blinded outcome assessment, and multi-domain outcomes with 6-month follow-up. Limitations include single-center design, modest sample size limiting subgroup analyses, lack of objective neurophysiological measures (electromyography [EMG]\/functional MRI [fMRI]) to confirm mechanisms, and the need to confirm durability beyond 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this randomized sham-controlled study, SNRMS produced clinically and statistically significant improvements in IELT, ejaculatory control, sexual satisfaction, and psychological well-being in men with PPE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf318","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:26:25Z","timestamp":1761045985000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of sacral nerve root magnetic stimulation in primary premature ejaculation: mechanistic and clinical analysis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5752-9756","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second People\u2019s Hospital of Hefei , Hefei 230011, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"1","key":"2026010506134594500_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00926230490475252","article-title":"The neurobiological basis of premature ejaculation","volume":"31","author":"Waldinger","year":"2005","journal-title":"J Sex Marital 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