{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:02:42Z","timestamp":1779393762920,"version":"3.53.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Erectile dysfunction (ED) is increasingly recognized as a marker of vascular health, yet its incidence following myocardial infarction (MI) remains imprecisely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To quantify the pooled incidence of de novo ED after first-time MI and to examine its correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Via a systematic review and meta-analysis, PubMed\/MEDLINE and Web of Science were searched from inception to June 10, 2025, for studies enrolling adult men without prior ED and assessing post-MI ED using validated instruments (5-item International Index of Erectile Function or 15-item International Index of Erectile Function). Incidence estimates were pooled using random-effects meta-analysis and between-study heterogeneity assessed with I2. Sensitivity analyses included leave-one-out models; narrative syntheses described timing of onset and secondary sexual outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The main primary outcome was pooled incidence of de novo ED after first MI, while secondary outcomes included timing of ED onset, severity correlates, and changes in sexual activity\/intercourse frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five studies (n\u2009=\u2009428 MI survivors) met inclusion criteria. Among the 428 men, 271 developed new ED post-MI, yielding a pooled incidence of 64.4% (95% CI, 44.0-85.0). Between-study heterogeneity was high (I2\u2009=\u200990%). Narrative data indicate that most cases manifest within 6 months post-MI, and severity correlates with age and comorbid burden. Reporting on sexual activity resumption and intercourse frequency revealed significant declines compared to pre-MI levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>De novo ED is common and arises early after first MI. If clinically suspected, screening for sexual dysfunction, incorporation of structured sexual counseling into cardiac rehabilitation, and timely consideration of therapeutic interventions may be considered to improve quality of life and potentially signal broader cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and Limitations<\/jats:title>\n                    <jats:p>Focus on incident cases and use of validated ED instruments showing likely association in MI-ED development, but limited by small number of eligible studies, incomplete baseline reporting, and high between-study heterogeneity limiting precision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>New-onset ED affects a substantial proportion of men after a first MI and commonly appears within months of the event. These findings may warrant consideration of assessment of sexual function in post-MI care and integration of targeted interventions into recovery programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf338","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:19:44Z","timestamp":1762435184000},"source":"Crossref","is-referenced-by-count":1,"title":["De novo erectile dysfunction after first myocardial infarction: systematic review and meta-analysis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-6537","authenticated-orcid":false,"given":"Carlson","family":"Sama","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Institute , Morgantown, WV 26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Al-Saed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, West Virginia University Hospital , Morgantown, WV26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efeturi","family":"Okorigba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, West Virginia University Hospital , Morgantown, WV26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalla Kara","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Institute , Morgantown, WV 26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huzaifah","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, West Virginia University Hospital , Morgantown, WV26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Warrier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, West Virginia University Hospital , Morgantown, WV26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Institute , Morgantown, WV 26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muchi Ditah","family":"Chobufo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Institute , Morgantown, WV 26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshith","family":"Thyagaturu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Vascular Institute , Morgantown, WV 26506 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"2026010506163296100_ref1","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","article-title":"A systematic review of the association between erectile dysfunction and cardiovascular disease","volume":"65","author":"Gandaglia","year":"2014","journal-title":"Eur Urol"},{"key":"2026010506163296100_ref2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1161\/HYPERTENSIONAHA.114.03505","article-title":"Erectile dysfunction: a marker of increased cardiovascular risk","volume":"64","author":"Jackson","year":"2014","journal-title":"Hypertension."},{"key":"2026010506163296100_ref3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/MCA.0000000000000145","article-title":"Microvascular endothelial dysfunction predicts the development of erectile dysfunction in men with coronary atherosclerosis without critical stenoses","volume":"25","author":"Reriani","year":"2014","journal-title":"Coron Artery Dis"},{"key":"2026010506163296100_ref4","doi-asserted-by":"publisher","first-page":"19M","DOI":"10.1016\/j.amjcard.2005.07.006","article-title":"The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease","volume":"96","author":"Montorsi","year":"2005","journal-title":"Am J Cardiol"},{"key":"2026010506163296100_ref5","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13643-024-02525-0","article-title":"Global prevalence of sexual dysfunction in cardiovascular patients: a systematic review and meta-analysis","volume":"13","author":"Ziapour","year":"2024","journal-title":"System Rev"},{"key":"2026010506163296100_ref6","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/aja.2012.41","article-title":"Comparison between primary angioplasty and thrombolytic therapy on erectile dysfunction after acute ST elevation myocardial infarction","volume":"14","author":"Akdemir","year":"2012","journal-title":"Asian J Androl"},{"key":"2026010506163296100_ref7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/sj.ijir.3901274","article-title":"Distress: associated variables of erectile dysfunction post-acute myocardial infarction. A pilot study","volume":"17","author":"Vacanti","year":"2005","journal-title":"Int J Impot Res"},{"key":"2026010506163296100_ref8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1590\/S1677-5538.IBJU.2013.04.03","article-title":"Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?","volume":"39","author":"Canat","year":"2013","journal-title":"Int Braz J Urol"},{"key":"2026010506163296100_ref9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.17392\/981-19","article-title":"Effect of myocardial infarction on the occurrence of erectile dysfunction","volume":"16","author":"Hod\u017ei\u0107","year":"2019","journal-title":"Med Glas (Zenica)"},{"key":"2026010506163296100_ref10","first-page":"185","article-title":"Erectile dysfunction after myocardial infarction--myth or a real problem?","volume":"31","author":"Ruzi\u0107","year":"2007","journal-title":"Coll Antropol"},{"key":"2026010506163296100_ref11","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.jsxm.2019.04.004","article-title":"Erectile dysfunction predicts cardiovascular events as an independent risk factor: a systematic review and meta-analysis","volume":"16","author":"Zhao","year":"2019","journal-title":"J Sex Med"},{"issue":"10","key":"2026010506163296100_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101103","article-title":"The prevalence of erectile dysfunction and its association with cardiovascular risk factors in patients after myocardial infarction","volume":"57","author":"Rink\u016bnien\u0117","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"2026010506163296100_ref13","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1093\/eurheartj\/ehl142","article-title":"Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial","volume":"27","author":"Montorsi","year":"2006","journal-title":"Eur Heart J"},{"key":"2026010506163296100_ref14","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1001\/jamacardio.2016.2362","article-title":"Sexual activity and function of younger patients after acute myocardial infarction","volume":"1","author":"Lindau","year":"2016","journal-title":"JAMA Cardiol"},{"key":"2026010506163296100_ref15","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1093\/eurheartj\/eht270","article-title":"Sexual counselling for individuals with cardiovascular disease and their partners: a consensus document from the American Heart Association and the ESC Council on cardiovascular nursing and allied professions (CCNAP)","volume":"34","author":"Steinke","year":"2013","journal-title":"Eur Heart J"},{"key":"2026010506163296100_ref16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1161\/CIRCHEARTFAILURE.108.802116","article-title":"Phosphodiesterase-5 inhibition in chronic heart failure\u2014an emerging therapeutic opportunity","volume":"1","author":"Guazzi","year":"2008","journal-title":"Circ Heart Fail"},{"key":"2026010506163296100_ref17","article-title":"Cardiac rehabilitation linked to improved sexual functioning and frequency"},{"key":"2026010506163296100_ref18","doi-asserted-by":"publisher","first-page":"qfae043","DOI":"10.1093\/sexmed\/qfae043","article-title":"Impact of cardiac rehabilitation on erectile dysfunction in cardiovascular patients: a systematic review and meta-analysis","volume":"12","author":"Sadeghi","year":"2024","journal-title":"Sex Med"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/23\/1\/qdaf338\/65661233\/qdaf338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/23\/1\/qdaf338\/65661233\/qdaf338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:16:39Z","timestamp":1767611799000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/doi\/10.1093\/jsxmed\/qdaf338\/8361809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdaf338","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"value":"1743-6095","type":"print"},{"value":"1743-6109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,11,30]]},"article-number":"qdaf338"}}