{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:41:46Z","timestamp":1782567706218,"version":"3.54.5"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>0.05% Chlorhexidine gluconate (CHG) is now commonly used as an antiseptic irrigation for inflatable penile prosthesis (IPP) surgery. Limited in vitro data suggest compatibility of 0.05% CHG with antibiotic impregnated IPP devices; however, very little clinical research exists to guide use of 0.05% CHG in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Assess the relationship of 0.05% CHG and antibiotic impregnated IPP infection in a large multi-institutional cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed a multi-institutional cohort of patients who underwent antibiotic impregnated IPP implantation. We identified cases using intraoperative 0.05% CHG and an equal number of consecutive control cases without 0.05% CHG use from each center for comparison. The primary outcome was IPP infection requiring explantation. Patient demographics and surgical variables were analyzed using chi-square tests and multivariable logistic regression to identify variables associated with infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The primary outcome was IPP infection requiring device explanation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 14 participating institutions, 761 cases using an antibiotic impregnated IPP were analyzed. Of these, 348 (45.7%) had 0.05% CHG used during the case. Median follow-up was 4\u00a0months (interquartile range 1-12) for the 0.05% CHG group and 8\u00a0months (interquartile range 2-21) for the control group.<\/jats:p>\n                    <jats:p>Intraoperative 0.05% CHG utilization was not associated with antibiotic impregnated IPP infection rate (1.9% vs. 2.0%, P\u00a0=\u2009.9). On multivariable analysis, prior IPP infection (OR 6.32, 95% CI 1.32-30.2, P\u00a0=\u2009.021) and prior priapism (OR 10.01, 95% CI 1.18-89.7, P\u00a0=\u2009.039) were associated with increased infection risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical implications<\/jats:title>\n                    <jats:p>The use of 0.05% CHG irrigation with antibiotic impregnated IPPs was associated with similar infection rates compared to antibiotic irrigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and limitations<\/jats:title>\n                    <jats:p>Limitations include the use of a historical comparator cohort which may introduce unknown confounders, practice variation between multiple sites, shorter follow-up in the 0.05% CHG cohort, and the low incidence of IPP infection which may limit statistical power despite a large sample. The major strengths include the large, multi-institutional cohort, and the use of consecutive patients to minimize selection bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>0.05% CHG utilization was not associated with infection rates in antibiotic impregnated IPPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdaf368","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:12:18Z","timestamp":1765545138000},"source":"Crossref","is-referenced-by-count":2,"title":["0.05% Chlorhexidine gluconate is not associated with infection in antibiotic impregnated inflatable penile prosthesis surgery: results from a large multi-institutional collaborative"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-5952","authenticated-orcid":false,"given":"Samuel J","family":"Ivan","sequence":"first","affiliation":[{"name":"Fox Chase-Temple Urologic Institute , Department of Urology, Philadelphia, PA 19111,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-896X","authenticated-orcid":false,"given":"Elia","family":"Abou Chawareb","sequence":"additional","affiliation":[{"name":"University of California-Irvine, Department of Urology , Orange, CA 92697,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Hammad","sequence":"additional","affiliation":[{"name":"University of California-Irvine, Department of Urology , Orange, CA 92697,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lesgart","sequence":"additional","affiliation":[{"name":"Fox Chase-Temple Urologic Institute , Department of Urology, Philadelphia, PA 19111,","place":["United 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L","family":"Bernie","sequence":"additional","affiliation":[{"name":"Indiana University, Department of Urology , Indianapolis, IN 46202,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raevti","family":"Bole","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University , Philadelphia, PA 10038,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketch","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Urology, Erlanger Health System , Chattanooga, TN 37403,","place":["United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Mass-Lindenbaum","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine , Cleveland, OH 44195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen F","family":"Morey","sequence":"additional","affiliation":[{"name":"Urology Clinics of North Texas , Dallas, TX 75093,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Urology, University of California San Diego , San Diego, CA 92103,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thairo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Indiana University, Department of Urology , Indianapolis, IN 46202,","place":["United 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decreases risk of infection in inflatable penile prosthesis implantation to 0.46%","volume":"79","author":"Eid","year":"2012","journal-title":"Urology."},{"issue":"5","key":"2026010506134577800_ref4","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1743-6109.2011.02207.x","article-title":"Antibiotic patterns with inflatable penile prosthesis insertion","volume":"8","author":"Wosnitzer","year":"2011","journal-title":"J Sex Med"},{"issue":"8","key":"2026010506134577800_ref5","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.21037\/tau-23-497","article-title":"Perioperative infection prevention during inflatable penile prosthesis surgery: a narrative review","volume":"13","author":"Matthew-Onabanjo","year":"2024","journal-title":"Transl Androl Urol"},{"issue":"9","key":"2026010506134577800_ref6","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1093\/jsxmed\/qdae093","article-title":"Minocycline-rifampin-impregnated penile prosthesis surfaces retain 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