{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T13:06:40Z","timestamp":1779023200464,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infection remains a major concern in inflatable penile prosthesis (IPP) surgery. Medtronic\u2019s TYRX Absorbable Antibacterial Envelope is a polypropylene mesh pocket delivering minocycline and rifampin for 7 days and fully absorbing in 9 weeks. It is currently FDA-approved for use with cardiac pacemakers and neuromodulation devices. There is no indication for use in IPP surgeries, particularly for enveloping the scrotal pump during implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This pilot study evaluates the feasibility, safety, and early patient-reported outcomes with the use of the absorbable antibacterial envelope during IPP surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen men who underwent primary or revision IPP placement by a single high-volume surgeon were enrolled between January and May 2025. Demographic and comorbidity data were collected. IPP pumps were placed in the absorbable antibacterial envelope and then positioned into a sub-dartos pouch; no other changes to standard-of-care surgical placement were made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The primary endpoint was the patient\u2019s ability to locate and operate the pump within 6 weeks after surgery. Secondary endpoints included infection and mechanical malfunction within 6 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen patients were enrolled and followed for up to 6 months postoperatively. Patients were able to utilize the pump by the 6-week visit. More than half of participants were overall \u201cvery\u201d or \u201cextremely\u201d satisfied (8\/15, 53%) and confident (12\/15, 80%) with the inflation and deflation process. No patient experienced infection or malfunction. One patient on anticoagulation and hemodialysis developed a scrotal hematoma, which resolved conservatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>These findings support continued evaluation of the absorbable antibacterial envelope as an adjunctive infection-prevention strategy in prosthetic urology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths &amp; Limitations<\/jats:title>\n                    <jats:p>To our knowledge, this is the first study to evaluate the absorbable antibacterial envelope in IPP surgery. Limitations include its single-center design, small sample size, short duration of follow-up, and lack of a control group for patient-reported outcome comparisons. This study was underpowered to evaluate the antibacterial envelope\u2019s efficacy or long-term infection outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Use of the absorbable antibacterial envelope in IPP surgery appears feasible and safe, with patients being able to utilize the pump postoperatively. No infection or mechanical malfunctions were encountered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag136","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:40:12Z","timestamp":1776944412000},"source":"Crossref","is-referenced-by-count":0,"title":["Use of TYRX antibacterial envelope in inflatable penile prosthesis surgery: a prospective pilot study"],"prefix":"10.1093","volume":"23","author":[{"given":"Jack T","family":"Rifkin","sequence":"first","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian H","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tej J","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"DeHoratius","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Kolesnikov","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"issue":"11","key":"2026051708112670900_ref1","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.jsxm.2019.08.001","article-title":"Long-term follow-up after penile prosthesis implantation-survival and quality of life outcomes","volume":"16","author":"Chierigo","year":"2019","journal-title":"J Sex Med"},{"issue":"3","key":"2026051708112670900_ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11934-019-0875-7","article-title":"Infection prevention considerations for complex penile prosthesis 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