{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T23:05:57Z","timestamp":1783897557919,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangdong Science and Technology Department","award":["2023B1212060028"],"award-info":[{"award-number":["2023B1212060028"]}]},{"name":"National Natural Science Foundation-Young Scientists Fund","award":["82500049"],"award-info":[{"award-number":["82500049"]}]},{"name":"China Post-doctoral Science Foundation","award":["2024\u00a0M760657"],"award-info":[{"award-number":["2024\u00a0M760657"]}]},{"name":"China Post-doctoral Science Foundation","award":["2025\u00a0M782880"],"award-info":[{"award-number":["2025\u00a0M782880"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20251324"],"award-info":[{"award-number":["GZC20251324"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20250983"],"award-info":[{"award-number":["GZC20250983"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that regulates diverse biological processes, including osmoregulation, thermosensation, and ion transport. As a key component of the female reproductive tract, the vaginal epithelium plays a crucial role in maintaining luminal moisture and lubrication. However, the contribution of TRPV4 to vaginal epithelial function remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To characterize the expression pattern of TRPV4 in vaginal epithelial cells and to elucidate its physiological role in regulating transepithelial ion transport and vaginal lubrication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female SD rats were used in this study. Primary culture of rat vaginal epithelial cells was established. TRPV4 expression levels, transepithelial ion transport, and vaginal fluid secretion were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The primary outcome of the study was the functional relationship between TRPV4 activation and vaginal lubrication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TRPV4 was expressed in rat vaginal epithelial cells and that its activation promoted transepithelial K+ secretion across vaginal epithelium. Pharmacological blockade of large-conductance Ca2+-activated K+ channel (BKCa) but not ATP-sensitive K+ channel significantly attenuated TRPV4-mediated transepithelial K+ secretion, indicating functional coupling between TRPV4 and BKCa. In vivo studies revealed that activation of TRPV4 robustly enhanced vaginal fluid secretion in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical implications<\/jats:title>\n                    <jats:p>TRPV4-BKCa axis represents a potential molecular target for the treatment of female reproductive disorders characterized by vaginal dryness and impaired lubrication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and limitations<\/jats:title>\n                    <jats:p>The combined in vitro and in vivo approaches provide mechanistic insight into TRPV4-mediated regulation of vaginal fluid secretion. However, the absence of human tissues or clinical data limits the direct translational extrapolation of these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies TRPV4 as a key regulator of vaginal moistness and lubrication, providing novel insights into the physiological mechanisms governing female reproductive function and suggesting new therapeutic avenues for conditions associated with vaginal dryness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag215","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T22:44:16Z","timestamp":1783896256000},"source":"Crossref","is-referenced-by-count":0,"title":["Activation of TRPV4 promotes transepithelial K+ secretion in rat vaginal 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