{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:14:24Z","timestamp":1783718064225,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"2024 China National Health Commission Research Project","award":["WKZX2024ED1018"],"award-info":[{"award-number":["WKZX2024ED1018"]}]},{"name":"2025 Research Projects of Sichuan Medical Association","award":["S20250084"],"award-info":[{"award-number":["S20250084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension is an important risk factor for erectile dysfunction. Yes-associated protein (YAP) is a multifunctional protein involved in diverse biological processes; whether hypertension influences erectile function through the regulation of YAP remains unclear; therefore, this study investigated whether hypertension impairs erectile function in spontaneously hypertensive rats (SHR) by upregulating YAP expression in the penile corpus cavernosum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve 8-week-old male WKY rats were randomly divided into the WKY group and the WKY\u2009+\u2009LV group (n\u00a0=\u20096), and twenty-four 8-week-old male SHR rats were randomly divided into four groups: the SHR group, SHR\u2009+\u2009NC group, SHR\u2009+\u2009LV group, and SHR\u2009+\u2009RES group (n\u00a0=\u20096). SHR\u2009+\u2009RES group received resveratrol (10\u00a0mg\/kg\/d) by gavage for 4\u00a0weeks, and the WKY\u2009+\u2009LV,SHR\u2009+\u2009LV and SHR\u2009+\u2009NC groups were treated with a single intracavernosal injection of YAP siRNA lentivirus or empty vector (20\u00a0\u03bcL\/rat, 1\u2009\u00d7\u2009109 TU\/mL) at week 4. One week later, ICPmax\/MAP, serum testosterone, NO, and expression of YAP, Caspase-1, Gasdermin D-N, Caspase-3, and p-eNOS\/eNOS in the corpus cavernosum were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>YAP was predominantly expressed in the cytoplasm and nuclei of endothelial cells in the corpus cavernosum. Compared with the WKY group, the SHR group showed significantly lower NO levels, ICPmax\/MAP, and p-eNOS\/eNOS expression, but significantly higher expression of YAP, Caspase-1, GSDMD-N, and Caspase-3. In contrast, both the SHR\u2009+\u2009LV and SHR\u2009+\u2009RES groups showed significantly increased NO levels and ICPmax\/MAP, decreased YAP, Caspase-1, GSDMD-N, and Caspase-3 expression, and reduced endothelial apoptosis and pyroptosis compared with the SHR group (P\u00a0&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Hypertension impairs erectile function by upregulating YAP expression in the penile corpus cavernosum, thereby promoting endothelial apoptosis and pyroptosis and reducing p-eNOS\/eNOS and NO production, whereas resveratrol may ameliorate these changes by suppressing YAP expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag219","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:24:16Z","timestamp":1783715056000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertension up-regulates yes-associated protein expression in the penile corpus cavernosum and suppresses erectile function in spontaneously hypertensive rats"],"prefix":"10.1093","volume":"23","author":[{"given":"Yifan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, the Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan 646000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Longchang People's Hospital , Neijiang, Sichuan 642150 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, the Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan 646000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology, the Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan 646000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026071016241074200_ref1","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2026071016241074200_ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jare.2023.05.008","article-title":"Insights into modifiable risk factors of erectile dysfunction, a wide-angled mendelian randomization study","volume":"58","author":"Xiong","year":"2024","journal-title":"J Adv Res"},{"issue":"3","key":"2026071016241074200_ref3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/jch.14123","article-title":"Hypertension and erectile dysfunction: the role of endovascular therapy in Asia","volume":"23","author":"Wang","year":"2021","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"2","key":"2026071016241074200_ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/aja202433","article-title":"Autophagy in erectile dysfunction: focusing on apoptosis and fibrosis","volume":"27","author":"Luo","year":"2025","journal-title":"Asian J Androl"},{"issue":"1","key":"2026071016241074200_ref5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvw014","article-title":"Modulators of right ventricular apoptosis and contractility in a rat model of pulmonary hypertension","volume":"110","author":"Zungu-Edmondson","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"12","key":"2026071016241074200_ref6","first-page":"1126","article-title":"Cell apoptosis and male erectile dysfunction","volume":"14","author":"Rao","year":"2008","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"14","key":"2026071016241074200_ref7","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798321","article-title":"Mechanism of membrane pore formation by human gasdermin-D","volume":"37","author":"Mulvihill","year":"2018","journal-title":"EMBO J"},{"issue":"8","key":"2026071016241074200_ref8","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/jsxmed\/qdae067","article-title":"Mode of cell death in the penile cavernous tissue of type 1 diabetes mellitus rats","volume":"21","author":"Li","year":"2024","journal-title":"J Sex Med"},{"issue":"1","key":"2026071016241074200_ref9","doi-asserted-by":"crossref","first-page":"qfaf017","DOI":"10.1093\/sexmed\/qfaf017","article-title":"Icariin inhibits hyperglycemia-induced cell death in penile cavernous tissue and improves erectile function in type 1 diabetic rats","volume":"13","author":"Yang","year":"2025","journal-title":"Sex Med"},{"issue":"2","key":"2026071016241074200_ref10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00018-014-1742-9","article-title":"The mammalian hippo pathway: regulation and function of YAP1 and TAZ","volume":"72","author":"Kodaka","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"2026071016241074200_ref11","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"21","key":"2026071016241074200_ref12","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"issue":"7","key":"2026071016241074200_ref13","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tem.2018.04.006","article-title":"Hippo Signaling: key emerging pathway in cellular and whole-body metabolism","volume":"29","author":"Ardestani","year":"2018","journal-title":"Trends Endocrinol Metab"},{"issue":"9","key":"2026071016241074200_ref14","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/cdd.2017.99","article-title":"The LATS1 and LATS2 tumor suppressors: beyond the hippo pathway","volume":"24","author":"Furth","year":"2017","journal-title":"Cell Death Differ"},{"issue":"12","key":"2026071016241074200_ref15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123770","article-title":"The ambivalent function of YAP in apoptosis and cancer","volume":"19","author":"Zhang","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2026071016241074200_ref16","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1158\/0008-5472.CAN-07-6205","article-title":"Negative regulation of YAP by LATS1 underscores evolutionary conservation of the drosophila hippo pathway","volume":"68","author":"Zhang","year":"2008","journal-title":"Cancer Res"},{"issue":"4","key":"2026071016241074200_ref17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1083\/jcb.201806065","article-title":"YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility","volume":"218","author":"Mason","year":"2019","journal-title":"J Cell Biol"},{"issue":"12","key":"2026071016241074200_ref18","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1038\/emm.2014.77","article-title":"Role of LPA and the hippo pathway on apoptosis in salivary gland epithelial cells","volume":"46","author":"Hwang","year":"2014","journal-title":"Exp Mol Med"},{"issue":"8","key":"2026071016241074200_ref19","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s10495-011-0608-y","article-title":"YAP accelerates a\u03b2(25-35)-induced apoptosis through upregulation of Bax expression by interaction with p73","volume":"16","author":"Zhang","year":"2011","journal-title":"Apoptosis."},{"issue":"3","key":"2026071016241074200_ref20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.4049\/jimmunol.1200415","article-title":"Salmonella downregulates nod-like receptor family CARD domain containing protein 4 expression to promote its survival in B cells by preventing inflammasome activation and cell death","volume":"190","author":"Perez-Lopez","year":"2013","journal-title":"J Immunol"},{"issue":"9","key":"2026071016241074200_ref21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1017\/S0007114512003406","article-title":"Molecular mechanisms of the cardiovascular protective effects of polyphenols","volume":"108","author":"Andriantsitohaina","year":"2012","journal-title":"Br J Nutr"},{"key":"2026071016241074200_ref22","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.2147\/IJN.S259628","article-title":"Phytochemical-based nanomedicine for advanced cancer Theranostics: perspectives on clinical trials to clinical use","volume":"15","author":"Dhupal","year":"2020","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"2026071016241074200_ref23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10641963.2015.1089882","article-title":"Resveratrol lowers blood pressure in spontaneously hypertensive rats via calcium-dependent endothelial NO production","volume":"38","author":"Li","year":"2016","journal-title":"Clin Exp Hypertens"},{"key":"2026071016241074200_ref24","doi-asserted-by":"crossref","first-page":"113642","DOI":"10.1016\/j.biopha.2022.113642","article-title":"Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability","volume":"154","author":"Gruji\u0107-Milanovi\u0107","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"2026071016241074200_ref25","doi-asserted-by":"crossref","first-page":"120424","DOI":"10.1016\/j.lfs.2022.120424","article-title":"Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses","volume":"296","author":"Bal","year":"2022","journal-title":"Life Sci"},{"key":"2026071016241074200_ref26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jare.2024.01.005","article-title":"Resveratrol and p53: how are they involved in CRC plasticity and apoptosis?","volume":"66","author":"Brockmueller","year":"2024","journal-title":"J Adv Res"},{"key":"2026071016241074200_ref27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12933-016-0366-9","article-title":"Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum","volume":"15","author":"Boydens","year":"2016","journal-title":"Cardiovasc Diabetol"},{"issue":"5","key":"2026071016241074200_ref28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ijir.2013.6","article-title":"The potent relaxant effect of resveratrol in rat corpus cavernosum and its underlying mechanisms","volume":"25","author":"Dalaklioglu","year":"2013","journal-title":"Int J Impot Res"},{"key":"2026071016241074200_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/pr.8477","article-title":"Effects of dietary polyphenols on vasculogenic erectile dysfunction: a systematic review of pre-clinical studies","author":"Geraldo","year":"2025","journal-title":"Phytother Res"},{"issue":"Pt 1","key":"2026071016241074200_ref30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2022.10.077","article-title":"Resveratrol inhibits proliferation and induces apoptosis via the hippo\/YAP pathway in human colon cancer cells","volume":"636","author":"Qin","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2026071016241074200_ref31","doi-asserted-by":"crossref","DOI":"10.3390\/nu8100546","article-title":"YAP inhibition by resveratrol via activation of AMPK enhances the sensitivity of pancreatic cancer cells to gemcitabine","volume":"8","author":"Jiang","year":"2016","journal-title":"Nutrients."},{"issue":"2","key":"2026071016241074200_ref32","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1038\/emm.2016.151","article-title":"Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA\/YAP signaling axis","volume":"49","author":"Kim","year":"2017","journal-title":"Exp Mol Med"},{"issue":"10","key":"2026071016241074200_ref33","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/1440-1681.13546","article-title":"Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGF\u03b21-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers","volume":"48","author":"ShamsEldeen","year":"2021","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"2026071016241074200_ref34","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s10753-021-01586-w","article-title":"Resveratrol alleviates hepatic fibrosis in associated with decreased endoplasmic reticulum stress-mediated apoptosis and inflammation","volume":"45","author":"Ma","year":"2022","journal-title":"Inflammation."},{"issue":"1","key":"2026071016241074200_ref35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/1673-5374.264464","article-title":"Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury","volume":"15","author":"Yang","year":"2020","journal-title":"Neural Regen Res"},{"issue":"11","key":"2026071016241074200_ref36","doi-asserted-by":"crossref","first-page":"e0166652","DOI":"10.1371\/journal.pone.0166652","article-title":"The influence of isoflurane anaesthesia on the rat grimace scale","volume":"11","author":"Miller","year":"2016","journal-title":"PLoS One"},{"issue":"194","key":"2026071016241074200_ref37","doi-asserted-by":"publisher","DOI":"10.3791\/64954","article-title":"Rat model of normothermic ex-situ perfused heterotopic heart transplantation","author":"Kayumov","year":"2023","journal-title":"J Vis Exp"},{"issue":"6","key":"2026071016241074200_ref38","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/andr.12844","article-title":"Low androgen status inhibits erectile function by inducing eNOS uncoupling in rat corpus cavernosum","volume":"8","author":"Xiong","year":"2020","journal-title":"Andrology."},{"issue":"1","key":"2026071016241074200_ref39","doi-asserted-by":"crossref","first-page":"e43053","DOI":"10.5812\/ijem.43053","article-title":"The effects of testosterone deficiency and its replacement on inflammatory markers in rats: a pilot study","volume":"15","author":"Chin","year":"2017","journal-title":"Int J Endocrinol Metab"},{"issue":"3","key":"2026071016241074200_ref40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jsxmed\/qdaf014","article-title":"Icariin improves erectile function in spontaneously hypertensive rats by downregulating GRK2 in penile cavernous tissue","volume":"22","author":"Li","year":"2025","journal-title":"J Sex Med"},{"key":"2026071016241074200_ref41","doi-asserted-by":"crossref","first-page":"910564","DOI":"10.1155\/2014\/910564","article-title":"Identification of endothelial progenitor cells in the corpus cavernosum in rats","volume":"2014","author":"Lee","year":"2014","journal-title":"Biomed Res Int"},{"issue":"2","key":"2026071016241074200_ref42","doi-asserted-by":"crossref","first-page":"qfad017","DOI":"10.1093\/sexmed\/qfad017","article-title":"Low testosterone state inhibits erectile function by downregulating the expression of GIT1 in rat penile corpus cavernosum","volume":"11","author":"Gu","year":"2023","journal-title":"Sex Med"},{"issue":"1","key":"2026071016241074200_ref43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12916-024-03609-3","article-title":"IL-17A exacerbates corpus cavernosum fibrosis and neurogenic erectile dysfunction by inducing CSMC senescence via the mTORC2-ACACA pathway","volume":"22","author":"Yang","year":"2024","journal-title":"BMC Med"},{"issue":"1","key":"2026071016241074200_ref44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/excr.2000.4955","article-title":"Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation","volume":"259","author":"Bedner","year":"2000","journal-title":"Exp Cell Res"},{"issue":"7484","key":"2026071016241074200_ref45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature12940","article-title":"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection","volume":"505","author":"Doitsh","year":"2014","journal-title":"Nature."},{"issue":"5","key":"2026071016241074200_ref46","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"2026071016241074200_ref47","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","article-title":"Pyroptosis: molecular mechanisms and roles in disease","volume":"35","author":"Broz","year":"2025","journal-title":"Cell Res"},{"issue":"9","key":"2026071016241074200_ref48","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1182\/blood.V98.9.2603","article-title":"Cellular stress response and apoptosis in cancer therapy","volume":"98","author":"Herr","year":"2001","journal-title":"Blood."},{"issue":"1","key":"2026071016241074200_ref49","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1038\/s41467-023-39009-z","article-title":"The role of mechano-regulated YAP\/TAZ in erectile dysfunction","volume":"14","author":"Ji","year":"2023","journal-title":"Nat Commun"},{"issue":"45","key":"2026071016241074200_ref50","doi-asserted-by":"crossref","first-page":"e2210809119","DOI":"10.1073\/pnas.2210809119","article-title":"The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1\/11","volume":"119","author":"Hu","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2026071016241074200_ref51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13567-024-01376-w","article-title":"RACK1 and NEK7 mediate GSDMD-dependent macrophage pyroptosis upon Streptococcus suis infection","volume":"55","author":"Shen","year":"2024","journal-title":"Vet Res"},{"issue":"10","key":"2026071016241074200_ref52","doi-asserted-by":"crossref","first-page":"e26391","DOI":"10.1371\/journal.pone.0026391","article-title":"Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure","volume":"6","author":"Rimbaud","year":"2011","journal-title":"PLoS One"},{"issue":"23","key":"2026071016241074200_ref53","doi-asserted-by":"crossref","DOI":"10.3390\/nu16234076","article-title":"Resveratrol butyrate esters reduce hypertension in a juvenile rat model of chronic kidney disease exacerbated by microplastics","volume":"16","author":"Huang","year":"2024","journal-title":"Nutrients."}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/23\/8\/qdag219\/68756712\/qdag219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/23\/8\/qdag219\/68756712\/qdag219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:24:22Z","timestamp":1783715062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/doi\/10.1093\/jsxmed\/qdag219\/8732209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jsxmed\/qdag219","relation":{},"ISSN":["1743-6095","1743-6109"],"issn-type":[{"value":"1743-6095","type":"print"},{"value":"1743-6109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,3]]},"article-number":"qdag219"}}