{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:45Z","timestamp":1787124525064,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"High-Level Talent Introduction Project of the Affiliated Hospital of Guizhou Medical University","award":["gyfygcc-2024-01"],"award-info":[{"award-number":["gyfygcc-2024-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peyronie\u2019s disease (PD) causes debilitating penile curvature. For moderate-to-severe cases failing conservative therapy, plaque incision\/excision with graft repair is a surgical option for selected patients, but it carries risks of erectile dysfunction and penile shortening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To report outcomes of a modified technique combining microscopic plaque grinding with a high-speed micro-burr and graft reconstruction (autologous tunica vaginalis or bovine pericardial patch) in moderate-to-severe PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center retrospective cohort study of 45 patients (curvature &amp;gt;60\u00b0 or compound deformities) treated between January 2021 and December 2025. The median follow-up was 11.5\u00a0months (range 6-24\u00a0months). Outcomes included penile straightening rate, erectile function (International Index of Erectile Function-5 [IIEF-5]), disease-specific bother, complications, and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Outcomes: The primary outcome was satisfactory penile straightening (residual curvature \u226410\u00b0). Secondary outcomes included IIEF-5 score, bother score, satisfaction, and complication rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Satisfactory penile straightening (residual curvature \u226410\u00b0) was achieved in 91.1% (41\/45); 8.9% had residual curvature between 10\u00b0 and 20\u00b0, which was considered acceptable and did not affect sexual function. International Index of Erectile Function-5 remained stable (preoperative: 20.8\u2009\u00b1\u20092.1 vs. postoperative: 20.4\u2009\u00b1\u20092.0, P\u2009=\u20090.360). Transient glans hypoesthesia occurred in 75.6% and resolved within a median of 2.0\u00a0months (range 0.7-2.8). Subjective penile shortening was reported by 53.3%, whereas objective measurement showed a mean increase of +1.4\u00a0cm in stretched penile length. The Peyronie\u2019s Disease Questionnaire symptom bother score decreased significantly from a median of 13 to 2 (P\u2009&amp;lt;\u20090.001). The satisfaction rate (score\u2009\u2265\u20094) was 93.3%. No significant differences were observed between graft types (autologous tunica vaginalis n\u2009=\u200934 vs. bovine pericardial patch n\u2009=\u200911).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>This technique offers effective curvature correction with preserved erectile function in selected patients with moderate-to-severe PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths and Limitations<\/jats:title>\n                    <jats:p>Strengths include (1) the use of microsurgical technique and electric plaque grinding, (2) meticulous tunica vaginalis repair and Buck\u2019s fascia reconstruction, (3) independent outcome assessment, and (4) complete follow-up exceeding 6\u00a0months. Limitations include the single-center retrospective design, small sample size, and non-randomized graft selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microscopic plaque grinding with graft repair appears to be a preferred surgical approach for curvature correction while maintaining stable erectile function in selected patients. Larger prospective studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag240","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:14:35Z","timestamp":1785323675000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical effect of microscopic plaque grinding combined with graft repair in the treatment of Peyronie\u2019s disease: a retrospective cohort study"],"prefix":"10.1093","volume":"23","author":[{"given":"Lin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Urology, The Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, Guizhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiujiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology, The Affiliated Hospital of Guizhou Medical University , Guiyang, 550004, Guizhou 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