{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:04:46Z","timestamp":1789571086692,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Selective dorsal cryoneurolysis (SDC) is a minimally invasive, potentially reversible neuromodulatory intervention for men with lifelong premature ejaculation (PE) refractory to conventional therapy.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To evaluate the efficacy, safety, and objective sensory effects of SDC in men with lifelongPE.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort included 108 men with lifelong PE (mean age 40.4\u2009\u00b1\u200911.6\u00a0years; body mass index 25.5\u2009\u00b1\u20093.2\u00a0kg\/m2) who underwent SDC between January 2024 and January 2025. All reported stopwatch-measured intravaginal ejaculatory latency time (IELT) &lt;1\u00a0min, normal erectile function, and inadequate response to pharmacological and behavioral treatment. Intravaginal ejaculatory latency time, Premature Ejaculation Diagnostic Tool (PEDT), Premature Ejaculation Profile (PEP), penile vibration-perception thresholds (biothesiometry), adverse events, and treatment failure were assessed to 12\u00a0months. Complete data were available for all patients, with no loss to follow-up. Normality was tested with Shapiro\u2013Wilk; changes over time were analyzed with Wilcoxon signed-rank and paired t-tests and the Friedmantest.<\/jats:p>\n <\/jats:sec>\n \n Outcomes<\/jats:title>\n The primary outcome was change in IELT; secondary outcomes were PEDT and PEP scores and adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Geometric-mean IELT rose from 54.4\u00a0s (95% confidence interval [CI], 45.8-64.5) to 231.3\u00a0s at 12\u00a0months (95% CI, 209.1-256.0)\u2014an approximately 4-fold improvement first reached by month 3 and sustained thereafter (P\u2009&lt;\u2009.001). Premature Ejaculation Diagnostic Tool decreased from 14.3\u2009\u00b1\u20092.3 to 8.4\u2009\u00b1\u20092.1 and the total PEP score increased from 6.0\u2009\u00b1\u20092.0 to 11.6\u2009\u00b1\u20092.4 (both P\u2009&lt;\u2009.001). Penile thresholds rose from ~4.5 to ~10.7\u00a0V at all sites (P\u2009&lt;\u2009.001), confirming objective desensitization. Procedure-related discomfort occurred in 8\/108 patients (7.4%), all mild and self-limiting, and persistent PE in 11\/108 (10.2%); 82\/108 (75.9%) underwent a second and 22\/108 (20.4%) a third session. No erectile dysfunction, anorgasmia, persistent numbness, or infection occurred.<\/jats:p>\n <\/jats:sec>\n \n Clinical Implications<\/jats:title>\n Selective dorsal cryoneurolysis provides significant, sustained improvements in ejaculatory latency and patient-reported outcomes without compromising sexual function, although approximately one in ten patients did not achieve a meaningful response.<\/jats:p>\n <\/jats:sec>\n \n Strengths and Limitations<\/jats:title>\n Strengths include a relatively large cohort, standardized outcome measures, and objective sensory (biothesiometry) testing. Limitations include the retrospective, uncontrolled, non-randomized design, and the absence of partner-reported outcomes.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Selective dorsal cryoneurolysis appears to be a safe, effective, minimally invasive, and potentially reversible option for refractory lifelong PE, positioned between pharmacotherapy and permanent neurotomy. It remains investigational, and prospective randomized controlled trials are warranted to confirm long-term durability and comparative efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag284","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:18:46Z","timestamp":1788520726000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes of selective dorsal cryoneurolysis in patients with lifelong premature ejaculation: a retrospective cohort of 108 men"],"prefix":"10.1093","volume":"23","author":[{"given":"Yasar","family":"Basaga","sequence":"first","affiliation":[{"name":"School of Medicine, Urology Department, Nisantasi University , Istanbul , 34398,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-5686","authenticated-orcid":false,"given":"Ahmet Tevfik","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Sisli Hamidiye Etfal Training and Research Hospital, Urology Department, University of Health Sciences , Istanbul , 34396,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfu","family":"Sertkaya","sequence":"additional","affiliation":[{"name":"Zulfu Sertkaya Men's Health Clinic , Istanbul , 34010,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ege Can","family":"Serefo\u011flu","sequence":"additional","affiliation":[{"name":"School of Medicine, Urology Department, Biruni University , Istanbul , 34295,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"7","key":"2026091610315587100_ref1","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1111\/jsm.12180","article-title":"Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: a large observational study in 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