{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:59:25Z","timestamp":1791464365119,"version":"4.3.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U54AR068069-S1"],"award-info":[{"award-number":["U54AR068069-S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of Rare Diseases Research"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development","doi-asserted-by":"publisher","award":["P50HD103555"],"award-info":[{"award-number":["P50HD103555"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development","doi-asserted-by":"publisher","award":["1U54AR068069-0"],"award-info":[{"award-number":["1U54AR068069-0"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteogenesis Imperfecta (OI) is a rare genetic condition caused by an impairment in type I collagen production, resulting in several symptoms, including bone fragility and frequent fractures, bone deformities, and growth abnormalities. While physical characteristics of those with OI are well described, sexual experiences and challenges encountered by individuals with OI remain largely understudied. This study analyzed whether sexual esteem, sexual pain, desire, and emotional distress stratify between different self-reported OI types and health severity perception (HSP) groups. Sexual esteem was further evaluated to determine its relationship with the sex-related and psychosocial constructs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted with 300 adults with self-reported OI diagnoses. Participants completed self-report measures of sexual esteem, sexual desire, sexual pain, anxiety, depression, and HSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study identifies that sexual esteem is significantly different between OI types and individuals with mild vs moderate HSP. Significant associations are observed between sexual esteem with sexual pain and emotional distress. A hierarchical regression model identifies that HSP adds a significant and unique predictive value to sexual esteem. Interestingly, sexual desire was found to negatively correlate with sexual esteem. Overall, this study finds that both OI type and HSP should be considered to understand sexual well-being and highlights an important need for further research on how OI affects sexual well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Individuals with OI can have positive sexual experiences which may be moderated by self-reported OI type, HSP, and emotional distress; these findings provide understanding of what degree different facets of OI affect the sexual well-being of adults with OI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jsxmed\/qdag319","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:59:28Z","timestamp":1790164768000},"source":"Crossref","is-referenced-by-count":0,"title":["Understanding sexual esteem, sexual desire, and sexual pain in adults with Osteogenesis 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N","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine , Houston, TX, 77030 ,","place":["United States"]},{"name":"Texas Children\u2019s Hospital , Houston, TX , 77030,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Eve","family":"Robinson","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children\u2014Canada, McGill University , Montreal, QC H4A 0A9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Ayers","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, 45229 ,","place":["United States"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH , 45267,","place":["United 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