{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:27:02Z","timestamp":1780572422898,"version":"3.54.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In recent years, multiple outbreaks of measles associated with vaccine hesitancy occurred in high-income countries, where measles incidence had previously been low. Most safety data about the measles, mumps and rubella (MMR) vaccine are derived from studies conducted among children, whereas evidence regarding the safety profile of the vaccine in adults is scarce.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 2017, during an outbreak of measles in Europe, Israeli travellers to high-risk locations who were incompletely vaccinated, were urged to complete the two MMR vaccination schedule before their travel. In this prospective cohort study, we analysed adverse events (AEs) of MMR and MMRV (measles, mumps, rubella and varicella) vaccines among these travellers. All participants were followed up using structured questionnaires 2\u20134\u00a0weeks after vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seven hundred and eighty-five adult travellers whose median age was 49.2\u00a0years were vaccinated and followed up. Any AEs were reported by 25.2% of all participants; 11.6% reported local AEs, and 18.6% reported systemic AEs, none of which were severe. In general, AEs were much more common among female travellers (19.4% of males vs 30.1% of females (P\u2009&amp;lt;\u20090.001)). Local AEs, overall systemic AEs, headache and arthralgia were much more common among females, whereas rates of general malaise and fever were not statistically different between genders. We did not observe any significant differences in the rates of total, local or systemic AEs between the MMR and MMRV vaccines. Higher rates of systemic AEs were observed among participants who were younger and probably immunized once with MMR compared to older vaccines immunized once to measles only and to those who were never immunized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The current study demonstrated low rates of systemic AEs and no serious AEs following either MMR or MMRV administration. More AEs were reported among females, and rates of AEs were similar after either MMR or MMRV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jtm\/taab071","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T19:30:21Z","timestamp":1622230221000},"source":"Crossref","is-referenced-by-count":7,"title":["Safety of measles, rubella and mumps vaccines in adults: a prospective cohort study"],"prefix":"10.1093","volume":"28","author":[{"given":"Neuberger","family":"Ami","sequence":"first","affiliation":[{"name":"Bruce Rappaport Faculty of Medicine, Technion, HaAliya HaShniya St, Haifa, 3109601, Israel"},{"name":"Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, Haifa, 3109601, Israel"},{"name":"Unit of Infectious Diseases, Rambam Healthcare Campus, HaAliya HaShniya St, Haifa, 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadir","family":"Eyal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Kaplan Medical Center, Derech Pasternak 1, Rehovot, 7610001, Israel"},{"name":"Clalit Health Services, Jerusalem District, 9514622, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biber","family":"Asaf","sequence":"additional","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avni","family":"Chen","sequence":"additional","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brom","family":"Adi","sequence":"additional","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attias","family":"Drorit","sequence":"additional","affiliation":[{"name":"Maoz Travel Clinic, Jerusalem, 94622, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petersiel","family":"Neta","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, Haifa, 3109601, Israel"},{"name":"Unit of Infectious Diseases, Rambam Healthcare Campus, HaAliya HaShniya St, Haifa, 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallashi","family":"Hajar","sequence":"additional","affiliation":[{"name":"Bruce Rappaport Faculty of Medicine, Technion, HaAliya HaShniya St, Haifa, 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakedzon","family":"Stav","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, Haifa, 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schwartz","family":"Eli","sequence":"additional","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel"},{"name":"Maoz Travel Clinic, Jerusalem, 94622, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"2021122911111675200_ref1","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay080","article-title":"Measles cases hit record high in Europe in 2018","volume":"25","author":"Leong","year":"2018","journal-title":"J Travel Med"},{"key":"2021122911111675200_ref2","doi-asserted-by":"crossref","first-page":"e20190414","DOI":"10.1542\/peds.2019-0414","article-title":"Spread of Measles 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