{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:40Z","timestamp":1753877200668,"version":"3.41.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Infection with Mansonella perstans is a neglected filariasis, widely distributed in sub-Saharan Africa, characterized by an elusive clinical picture; treatment for mansonellosis is not standardized. This retrospective study aimed to describe the clinical features, treatment schemes and evolution, of a large cohort of imported cases of M. perstans infection seen in four European centres for tropical diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mansonella perstans infections, diagnosed by identification of blood microfilariae in migrants, expatriates and travellers, collected between 1994 and 2018, were retrospectively analysed. Data concerning demographics, clinical history and laboratory examinations at diagnosis and at follow-up time points were retrieved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 392 patients were included in the study. Of the 281 patients for whom information on symptoms could be retrieved, 150 (53.4%) reported symptoms, abdominal pain and itching being the most frequent. Positive serology and eosinophilia were present in 84.4% and 66.1%, respectively, of those patients for whom these data were available. Concomitant parasitic infections were reported in 23.5% of patients. Treatment, administered to 325 patients (82.9%), was extremely heterogeneous between and within centres; the most commonly used regimen was mebendazole 100\u00a0mg twice a day for 1 month. A total of 256 (65.3%) patients attended a first follow-up, median 3\u00a0months (interquartile range 2\u201312) after the first visit; 83.1% of patients having received treatment based on mebendazole and\/or doxycycline, targeting Wolbachia, became amicrofilaremic, 41.1\u201378.4% of whom within 12\u00a0months from single treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lack of specific symptoms, together with the inconstant positivity of parasitological and antibody-based assays in the infected population, makes the clinical suspicion and screening for mansonellosis particularly difficult. Prospective studies evaluating prevalence of infection in migrants from endemic areas, infection-specific morbidity, presence of Wolbachia endosymbionts in M. perstans populations from different geographical areas and efficacy of treatment regimens are absolutely needed to optimize the clinical management of infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jtm\/taac048","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T15:09:14Z","timestamp":1649862554000},"source":"Crossref","is-referenced-by-count":8,"title":["A large case series of travel-related <i>Mansonella perstans<\/i> (vector-borne filarial nematode): a TropNet study in Europe"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-3914","authenticated-orcid":false,"given":"Francesca","family":"Tamarozzi","sequence":"first","affiliation":[{"name":"Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Rodari","sequence":"additional","affiliation":[{"name":"Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Salas-Coronas","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Bottieau","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Jes\u00fas","family":"Soriano-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Cabeza-Barrera","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Van Esbroeck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-6822","authenticated-orcid":false,"given":"Dora","family":"Buonfrate","sequence":"additional","affiliation":[{"name":"Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico G","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"2022043018374889800_ref1","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.actatropica.2010.01.014","article-title":"Mansonella perstans filariasis in Africa","volume":"120","author":"Simonsen","year":"2011","journal-title":"Acta Trop"},{"key":"2022043018374889800_ref2","first-page":"9","article-title":"Mansonellosis: current perspectives","volume":"9","author":"Ta-Tang","year":"2018","journal-title":"Res Rep Trop Med"},{"key":"2022043018374889800_ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004184","article-title":"Cross-reactivity of filariais ICT cards in areas of contrasting endemicity of Loa loa and Mansonella perstans in Cameroon: implications for shrinking of the lymphatic filariasis map in the central African region","volume":"9","author":"Wanji","year":"2015","journal-title":"PLoS Negl Trop 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