{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:18:25Z","timestamp":1767903505988,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministry of Education, University and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Schistosomiasis is a neglected tropical disease caused by trematodes of the genus Schistosoma. Schistosoma haematobium causes urogenital schistosomiasis (UGS), a chronic disease characterized by pathology of the urogenital tract leading to potentially severe morbidity for which the treatment is poorly standardized. We conducted a survey in TropNet centres on the clinical presentations and management strategies of complicated urogenital schistosomiasis (cUGS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the clinical records of patients seen at TropNet centres over a 20-year timespan (January 2001\u2013December 2020). Case definition for cUGS included the presence of urogenital cancer, obstructive uropathy, kidney insufficiency of all grades and female or male genital involvement leading to infertility. Collected data included demographic information, patient category (traveller or migrant), imaging data, microbiological data (serology results and presence\/absence of eggs in urine), histological features and outcome at last visit recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight centres contributed with at least one case. Overall, 31 patients matched the inclusion criteria. Sub-Saharan Africa was the most likely place of infection for included patients. Median age was 30.6\u00a0years (range 21\u201346, interquartile ranges, IQR 27\u201333). Most patients (28\/31, 90.3%) were males. Hydronephrosis was the most frequent complication, being present in 18 (58.1%) patients, followed by cancer, present in 5 patients (16.1%); 27 patients (87.1%) required surgical management of some sort. Use of praziquantel varied across centres, with six different regimens employed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Very few cases of cUGSs were found in our survey, possibly indicating underdiagnosis of this condition. Hydronephrosis was the most frequently observed urogenital complication, and most patients required invasive procedures. Infection by S. haematobium can result in considerable morbidity, resulting in clinically challenging presentations requiring a multidisciplinary approach. As such, development of common protocols for early diagnosis and treatment is urgently needed.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jtm\/taac150","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T15:00:55Z","timestamp":1671721255000},"source":"Crossref","is-referenced-by-count":11,"title":["Management of imported complicated urogenital schistosomiasis in Europe: a TropNet retrospective study"],"prefix":"10.1093","volume":"30","author":[{"given":"Gregorio","family":"Basile","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence, 50134 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-3914","authenticated-orcid":false,"given":"Francesca","family":"Tamarozzi","sequence":"additional","affiliation":[{"name":"Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital , Negrar, 37024 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Salas-Coronas","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital Universitario Poniente , Almer\u00eda, 04700 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Jes\u00fas","family":"Soriano-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital Universitario Poniente , Almer\u00eda, 04700 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Luz\u00f3n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Tropical Medicine Unit, Hospital Universitario Poniente , Almer\u00eda, 04700 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital , Negrar, 37024 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-9407","authenticated-orcid":false,"given":"Spinello","family":"Antinori","sequence":"additional","affiliation":[{"name":"Luigi Sacco Department of Biomedical and Clinical Sciences, Universit\u00e0 di Milano , Milan, 20157 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Arsuaga","sequence":"additional","affiliation":[{"name":"Imported Diseases and International Health Referral Unit, High Level Isolation Unit, La Paz-Carlos III University Hospital , Madrid, 28029 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bartoloni","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence, 50134 Italy"},{"name":"Infectious and Tropical Diseases Unit, Careggi University and Hospital , Florence, 50134 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Rachele","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"University Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili , Brescia, 25125 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Giovanni","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Infectious - Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital , Negrar, 37024 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Travel Medicine and Human parasitology, Center of Competence, Baden-W\u00fcrtttemberg, Universit\u00e4t und Universit\u00e4tsklinikum T\u00fcbingen , T\u00fcbingen, 72074 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona, 08035 , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid, 28029 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona, 08035 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-8404","authenticated-orcid":false,"given":"Lorenzo","family":"Zammarchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence, 50134 Italy"},{"name":"Infectious and Tropical Diseases Unit, Careggi University and Hospital , Florence, 50134 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"2023022014392538400_","volume-title":"Schistosomiasis","author":"World Health Organization","year":"2021"},{"key":"2023022014392538400_","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 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