{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:26:57Z","timestamp":1788640017896,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Juan Rod\u00e9s","award":["JR18\/00022"],"award-info":[{"award-number":["JR18\/00022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged or recurrent gastrointestinal symptoms may persist after acute traveller\u2019s diarrhoea (TD), even after adequate treatment of the primary cause. This study aims to describe the epidemiological, clinical and microbiological characteristics of patients with post-infectious irritable bowel syndrome (PI-IBS) after returning from tropical or subtropical areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of patients presenting between 2009 and 2018 at the International Health referral centre in Barcelona with persistent gastrointestinal symptoms following a diagnosis of TD. PI-IBS was defined as the presence of persistent or recurrent gastrointestinal manifestations for at least 6 months after the diagnosis of TD, a negative stool culture for bacterial pathogens and a negative ova and parasite exam after targeted treatment. Epidemiological, clinical and microbiological variables were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 669 travellers with a diagnosis of TD. Sixty-eight (10.2%) of these travellers, mean age 33\u00a0years and 36 (52.9%) women, developed PI-IBS. The most frequently visited geographical areas were Latin America (29.4%) and the Middle East (17.6%), with a median trip duration of 30\u00a0days (IQR 14\u201396). A microbiological diagnosis of TD was made in 32 of these 68 (47%) patients, 24 (75%) of whom had a parasitic infection, Giardia duodenalis being the most commonly detected parasite (n\u2009=\u200920, 83.3%). The symptoms persisted for a mean of 15\u00a0months after diagnosis and treatment of TD. The multivariate analysis revealed that parasitic infections were independent risk factors for PI-IBS (OR 3.0, 95%CI 1.2\u20137.8). Pre-travel counselling reduced the risk of PI-IBS (OR 0.4, 95%CI 0.2\u20130.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our cohort, almost 10% of patients with travellers\u2019 diarrhoea developed persistent symptoms compatible with PI-IBS. Parasitic infections, mainly giardiasis, seem to be associated with PI-IBS.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jtm\/taad030","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T19:07:54Z","timestamp":1678216074000},"source":"Crossref","is-referenced-by-count":13,"title":["Post-infectious irritable bowel syndrome following a diagnosis of traveller\u2019s diarrhoea: a comprehensive characterization of clinical and laboratory parameters"],"prefix":"10.1093","volume":"30","author":[{"given":"Sergio","family":"Espa\u00f1a-Cueto","sequence":"first","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Germans Trias i Pujol University Hospital Infectious Diseases Department, , Badalona, Spain"},{"name":"The Fight Infections Foundation , Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Oliveira-Souto","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Goterris","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital and PROSICS Department of Microbiology, , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalv\u00e1","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-6060","authenticated-orcid":false,"given":"Elena","family":"Sulleiro","sequence":"additional","affiliation":[{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"},{"name":"Vall d\u2019Hebron University Hospital and PROSICS Department of Microbiology, , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital and PROSICS Department of Microbiology, , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-7790","authenticated-orcid":false,"given":"Maria Luisa","family":"Aznar","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Bosch-Nicolau","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona International Health Unit Vall d\u2019Hebron-Drassanes, Infectious Diseases Department, , Barcelona, Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Espinosa-Pereiro","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, PROSICS Barcelona, 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