{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:08Z","timestamp":1792794668356,"version":"4.5.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Uni\u00f3n Europea\u2014NextGenerationEU"},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIBER\u2014Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red","id":[{"id":"https:\/\/ror.org\/02g87qh62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melioidosis, caused by Burkholderia pseudomallei, may be considered a neglected tropical disease that remains underdiagnosed in many geographical areas. Travellers can act as the sentinels of disease activity, and data from imported cases may help complete the global map of melioidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search for imported melioidosis for the period 2016\u201322 was performed in PubMed and Google Scholar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 137 reports of melioidosis associated with travel were identified. The majority were males (71%) and associated with exposure in Asia (77%) (mainly Thailand, 41%, and India, 9%). A minority acquired the infection in the Americas\u2013Caribbean area (6%), Africa (5%) and Oceania (2%). The most frequent comorbidity was diabetes mellitus (25%) followed by underlying pulmonary, liver or renal disease (8, 5 and 3%, respectively). Alcohol\/tobacco use were noted for seven and six patients, respectively (5%). Five patients (4%) had associated non-human immunodeficiency virus (HIV)-related immunosuppression, and three patients (2%) had HIV infection. One patient (0.8%) had concomitant coronavirus disease 19. A proportion (27%) had no underlying diseases. The most frequent clinical presentations included pneumonia (35%), sepsis (30%) and skin\/soft tissue infections (14%). Most developed symptoms &amp;lt;1\u00a0week after return (55%), and 29% developed symptoms &amp;gt;12\u00a0weeks after. Ceftazidime and meropenem were the main treatments used during the intensive intravenous phase (52 and 41% of patients, respectively) and the majority (82%) received co-trimoxazole alone\/combination, for the eradication phase. Most patients had a favourable outcome\/survived (87%). The search also retrieved cases in imported animals or cases secondary to imported commercial products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As post-pandemic travel soars, health professionals should be aware of the possibility of imported melioidosis with its diverse presentations. Currently, no licensed vaccine is available, so prevention in travellers should focus on protective measures (avoiding contact with soil\/stagnant water in endemic areas). Biological samples from suspected cases require processing in biosafety level 3 facilities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jtm\/taad039","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T03:10:44Z","timestamp":1679713844000},"source":"Crossref","is-referenced-by-count":22,"title":["Travel-associated melioidosis: a narrative review"],"prefix":"10.1093","volume":"30","author":[{"given":"Francesca F","family":"Norman","sequence":"first","affiliation":[{"name":"Ram\u00f3n y Cajal University Hospital, IRYCIS, Universidad de Alcal\u00e1, CIBER de Enfermedades Infecciosas National Referral Unit for Tropical Diseases, Infectious Diseases Department, , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin H","family":"Chen","sequence":"additional","affiliation":[{"name":"Mount Auburn Hospital Division of Infectious Diseases and Travel Medicine, , Cambridge, MA , USA"},{"name":"Harvard Medical School Faculty of Medicine, , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"2023051915583568600_ref1","doi-asserted-by":"crossref","first-page":"15008","DOI":"10.1038\/nmicrobiol.2015.8","article-title":"Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis","volume":"1","author":"Limmathurotsakul","year":"2016","journal-title":"Nat Microbiol"},{"key":"2023051915583568600_ref2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S1473-3099(19)30157-4","article-title":"Global burden of melioidosis in 2015: a systematic review and data synthesis","volume":"19","author":"Birnie","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2023051915583568600_ref3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/QCO.0000000000000827","article-title":"Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and 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