{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:16:47Z","timestamp":1780345007416,"version":"3.54.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220211"],"award-info":[{"award-number":["220211"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:p>Diagnosing scrub typhus in travellers is challenging due to symptom similarities with other travel-related illnesses and limited early diagnostic tools. We present a distinctive case of scrub typhus in a child traveller, providing a comprehensive account of the case, the diagnostic challenges encountered, laboratory findings and the dynamics of antibodies.<\/jats:p>","DOI":"10.1093\/jtm\/taad143","type":"journal-article","created":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:27:51Z","timestamp":1699806471000},"source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic challenges and antibody kinetics in a paediatric traveller with scrub typhus"],"prefix":"10.1093","volume":"30","author":[{"given":"Panita","family":"Looareesuwan","sequence":"first","affiliation":[{"name":"Department of Social and Environmental Medicine , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Thai Travel Clinic , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Aiemjoy","sequence":"additional","affiliation":[{"name":"Division of Epidemiology , Department of Public Health Sciences, , Davis, CA , USA"},{"name":"University of California Davis School of Medicine , Department of Public Health Sciences, , Davis, CA , USA"},{"name":"Department of Microbiology and Immunology , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-0163","authenticated-orcid":false,"given":"Sakarn","family":"Charoensakulchai","sequence":"additional","affiliation":[{"name":"Thai Travel Clinic , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janjira","family":"Thaipadungpanit","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Department of Clinical Tropical Medicine , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jantana","family":"Wongsantichon","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ampai","family":"Tanganuchitcharnchai","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artharee","family":"Rungrojn","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Department of Microbiology , Faculty of Public Health, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Public Health, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D","family":"Blacksell","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Center for Tropical Medicine & Global Health , Nuffield Department of Medicine, , Oxford , UK"},{"name":"Oxford University , Nuffield Department of Medicine, , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-2765","authenticated-orcid":false,"given":"Wasin","family":"Matsee","sequence":"additional","affiliation":[{"name":"Thai Travel Clinic , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Hospital for Tropical Diseases, Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Department of Clinical Tropical Medicine , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Travel Medicine Research Unit , Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, , Bangkok , Thailand"},{"name":"Mahidol University , Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"2023122906164376300_ref1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4269\/ajtmh.12-0600","article-title":"A prospective evaluation of real-time PCR assays for the detection of Orientia tsutsugamushi and Rickettsia spp. for early diagnosis of rickettsial infections during the acute phase of undifferentiated febrile illness","volume":"89","author":"Watthanaworawit","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"2023122906164376300_ref2","doi-asserted-by":"crossref","first-page":"e0008858","DOI":"10.1371\/journal.pntd.0008858","article-title":"Diagnostic accuracy of an in-house Scrub typhus enzyme linked immunoassay for the detection of IgM and IgG antibodies in Laos","volume":"14","author":"Elders","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2023122906164376300_ref3","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/CVI.00390-15","article-title":"Comparative accuracy of the InBios Scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serology","volume":"22","author":"Kingston","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"2023122906164376300_ref4","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.4269\/ajtmh.21-1129","article-title":"Prevalence rate and distribution of eschar in patients with scrub typhus","volume":"106","author":"Yoo","year":"2022","journal-title":"Am J Trop Med Hyg"},{"key":"2023122906164376300_ref5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/tropej\/fmw027","article-title":"Distribution of eschar in pediatric scrub typhus","volume":"62","author":"Rose","year":"2016","journal-title":"J Trop Pediatr"},{"key":"2023122906164376300_ref6","doi-asserted-by":"crossref","first-page":"e0007158","DOI":"10.1371\/journal.pntd.0007158","article-title":"The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: a review of the evidence","volume":"13","author":"Saraswati","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"2023122906164376300_ref7","doi-asserted-by":"crossref","first-page":"622","DOI":"10.4269\/ajtmh.20-1019","article-title":"Analysis of 262 children with scrub typhus infection: a single-center experience","volume":"104","author":"Kispotta","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"2023122906164376300_ref8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/jpids\/piz014","article-title":"Clinical characteristics and outcome of children hospitalized with scrub typhus in an area of endemicity","volume":"9","author":"Wangrangsimakul","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"key":"2023122906164376300_ref9","doi-asserted-by":"crossref","first-page":"e0008233","DOI":"10.1371\/journal.pntd.0008233","article-title":"The estimated burden of scrub typhus in Thailand from national surveillance data (2003-2018)","volume":"14","author":"Wangrangsimakul","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2023122906164376300_ref10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2021.102062","article-title":"Imported scrub typhus in Europe: report of three cases and a literature review","volume":"42","author":"Costa","year":"2021","journal-title":"Travel Med Infect Dis"},{"key":"2023122906164376300_ref11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/tropicalmed7020018","article-title":"Rickettsiosis in Southeast Asia: summary for international travellers during the COVID-19 pandemic","volume":"7","author":"Ngamprasertchai","year":"2022","journal-title":"Trop Med Infect Dis"}],"container-title":["Journal of Travel Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jtm\/advance-article-pdf\/doi\/10.1093\/jtm\/taad143\/54136483\/taad143.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jtm\/article-pdf\/30\/8\/taad143\/54913888\/taad143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jtm\/article-pdf\/30\/8\/taad143\/54913888\/taad143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T06:16:59Z","timestamp":1703830619000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jtm\/article\/doi\/10.1093\/jtm\/taad143\/7413193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,11]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,11,11]]},"published-print":{"date-parts":[[2023,12,28]]}},"URL":"https:\/\/doi.org\/10.1093\/jtm\/taad143","relation":{},"ISSN":["1195-1982","1708-8305"],"issn-type":[{"value":"1195-1982","type":"print"},{"value":"1708-8305","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,11,11]]},"article-number":"taad143"}}