{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:47:12Z","timestamp":1789501632456,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A study was conducted to assess the safety and tolerability of the tetravalent live-attenuated dengue vaccine Qdenga\u00ae, which received marketing approval in Germany in 2022. The study evaluated vaccine-related reactions in a predominantly dengue-na\u00efve population, highlighting the importance of post-marketing surveillance as an essential component of safety evaluation for newly licensed vaccines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Following dengue vaccination, participants were recruited for an anonymous online questionnaire through the national \u2018Trav VacNet\u2019 network in Germany. The questionnaire focused on post-vaccination reactions up to 18\u00a0days after the first and second vaccination, as well as previous travel history and coadministration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study included 1176 participants, with a median age of 39\u00a0years (IQR 28\u201356), 53.2% female (n\u2009=\u2009625), 46.5% male (n\u2009=\u2009547), and 0.3% non-binary participants (n\u2009=\u20094). After the first dose, 51% of the participants reported systemic reactions such as headache [40% (190\/474)], weakness [40% (189\/474)], and malaise [32% (154\/474)], which were most pronounced between days 7 and 11 post vaccination. After the second dose, localized signs and symptoms such as pain at the injection site [22% (n\u2009=\u200955\/250)] were more common. Fever was more common after the first dose [20% (96\/474)] vs. 2% (6\/250) after the second. Females reported significantly more reactions than males after both vaccinations (1st dose P\u2009=\u20090.0002; 2nd dose P\u2009=\u20090.0003). A total of 334 (28%) co-administrations were reported whereby assessing adverse events were reported in 47% (157\/333) of participants, with the highest prevalence observed when combined with the Japanese encephalitis vaccine [56.8%, (42\/74)]. Differences in age groups were observed, with a decrease in reactions in the elderly (\u226565\u00a0years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Vaccine-related reactions were frequently reported, predominantly after the first dose in dengue-na\u00efve participants. Coadministration was a common strategy without significantly increasing side effects. The study provides important insights into reactogenicity and may help improve vaccination strategies in dengue-na\u00efve populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jtm\/taaf004","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T16:47:51Z","timestamp":1738514871000},"source":"Crossref","is-referenced-by-count":23,"title":["First clinical experiences with the tetravalent live vaccine against dengue (Qdenga\u00ae) in travellers: a multicentric TravVacNet study in Germany"],"prefix":"10.1093","volume":"32","author":[{"given":"Clara","family":"K\u00f6pke","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Saarland University , Homburg\/Saar , Kirrberger Str. 100, 66421 Homburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Rothe","sequence":"additional","affiliation":[{"name":"LMU University Hospital Centre, Institute of Infectious Diseases and Tropical Medicine , Leopoldstra\u00dfe 5, 80802 M\u00fcnchen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zeder","sequence":"additional","affiliation":[{"name":"LMU University Hospital Centre, Institute of Infectious Diseases and Tropical Medicine , Leopoldstra\u00dfe 5, 80802 M\u00fcnchen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Boecken","sequence":"additional","affiliation":[{"name":"Medical Service, German Foreign Office, Regional Medical Office West Africa , Accra, No. 1, Drive North Ridge, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Feldt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital D\u00fcsseldorf , Heinrich-Heine-University D\u00fcsseldorf, Moorenstr. 5, 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Janke","sequence":"additional","affiliation":[{"name":"LMU University Hospital Centre, Institute of Infectious Diseases and Tropical Medicine , Leopoldstra\u00dfe 5, 80802 M\u00fcnchen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine, I. Department of Medicine, University Medical Center Hamburg-Eppendorf and Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine , Hamburg, Bernhard-Nocht-Stra\u00dfe 7420359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen, Institute of Tropical Medicine , Wilhelmstra\u00dfe 2772074 T\u00fcbingen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha","family":"L\u00f6bermann","sequence":"additional","affiliation":[{"name":"University of Rostock, Department of Infectious Diseases and Tropical Medicine , Ernst-Heydemann-Stra\u00dfe 6, 18057 Rostock,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic II , Infectiology \/ Tropical Medicine W\u00fcrzburg, Oberd\u00fcrrbacher Stra\u00dfe 6, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Martin","family":"Orth","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital D\u00fcsseldorf , Heinrich-Heine-University D\u00fcsseldorf, Moorenstr. 5, 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise Marie","family":"Pr\u00fcfer-Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"MVZ am Franziskus Hospital, Private Practice for Tropical Medicine and Infectious Diseases , Internal Medicine, Bielefeld, Kiskerstra\u00dfe 19, 33615 Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Paul-Lechler Hospital T\u00fcbingen, Department of Tropical Medicine , Paul-Lechler-Stra\u00dfe 26, 72076 T\u00fcbingen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Slesak","sequence":"additional","affiliation":[{"name":"Paul-Lechler Hospital T\u00fcbingen, Department of Tropical Medicine , Paul-Lechler-Stra\u00dfe 26, 72076 T\u00fcbingen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Stich","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg, Medical Clinic and Polyclinic II , Infectiology \/ Tropical Medicine W\u00fcrzburg, Oberd\u00fcrrbacher Stra\u00dfe 6, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"B\u00e9lard","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen, Institute of Tropical Medicine , Wilhelmstra\u00dfe 2772074 T\u00fcbingen,","place":["Germany"]},{"name":"German 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