{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:08:05Z","timestamp":1789398485327,"version":"build-2803163510"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chikungunya is an expanding global health threat, with chronic arthralgia representing the main long-term driver of disability. Although many studies have assessed post-chikungunya outcomes, evidence remains fragmented and contradictory. We aimed to identify reproducible predictors of chronic arthralgia (\u22653\u00a0months) after laboratory-confirmed chikungunya and to distinguish stable prognostic signals from context-dependent associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, Cochrane Library and BVS\/LILACS from inception to 6 February 2026, without restrictions. Eligible studies compared participants with and without chronic arthralgia at follow-up and reported extractable baseline or acute-phase factors. Two reviewers independently screened records, extracted data and assessed risk of bias using QUIPS. Random-effects restricted maximum likelihood meta-analyses pooled odds ratios and mean differences, with subgroup analyses by follow-up window. PROSPERO: CRD420251169320.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1784 records, 29 studies were included, comprising 4108 participants: 1878 with chronic arthralgia and 2230 without. After harmonization, 22 predictors were meta-analysed. The most consistent associations were female sex [odds ratio (OR) 2.08, 95% confidence interval (CI) 1.77\u20132.46; I2\u00a0=\u20098.3%], comorbidity presence (1.99, 1.55\u20132.55; I2\u00a0=\u20090%) and high blood pressure (1.52, 1.13\u20132.04; I2\u00a0=\u200933.4%). In contrast, several acute-phase manifestations and treatment-related markers showed less stable, timing-dependent or study-sensitive associations. Overall risk of bias was high in most studies and moderate in the remainder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chronic post-chikungunya arthralgia was most reproducibly associated with readily identifiable baseline host factors, rather than with a uniform acute-severity phenotype. These findings suggest that risk stratification should not rely only on acute symptom burden, and that pre-existing vulnerability may define a clinically important high-risk group. Point-of-care identification of patients with these characteristics could support prioritization of follow-up and resource allocation during outbreaks, inform post-outbreak surveillance and guideline development, and may guide future burden-based vaccination strategies in endemic settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jtm\/taag078","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:22:23Z","timestamp":1787937743000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of chronic arthralgia after chikungunya virus infection: a systematic review and meta-analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5508-0679","authenticated-orcid":false,"given":"Lucas Bussiki Corr\u00eaa da Costa","family":"Kotecki","sequence":"first","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0941-5587","authenticated-orcid":false,"given":"Vit\u00f3ria Diniz","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Bussiki Corr\u00eaa da Costa","family":"Kotecki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2740-1490","authenticated-orcid":false,"given":"Bianca Gabriela Tavares","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5598-2063","authenticated-orcid":false,"given":"Miguel Chaves","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of Rio Grande do Norte , Mossor\u00f3 , Rio Grande do Norte,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Pasqualette","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2343-1764","authenticated-orcid":false,"given":"Rafaela Coelho","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor Kayser","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Figueredo Nascimento Salom\u00e3o","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine, FG University Center , Brumado , Bahia,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5419-2576","authenticated-orcid":false,"given":"Gabriela Stutz F","family":"Moreira","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Medicine, Federal Hospital of Servants of Rio de Janeiro , Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Aldair","family":"Kotecki","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Life Human Reproduction , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Pompeu","family":"Salom\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Fortes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Varzea Grande University Center , Cuiab\u00e1, Mato Grosso 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Immunol"},{"key":"2026091410315368900_ref24","doi-asserted-by":"crossref","first-page":"e0008467","DOI":"10.1371\/journal.pntd.0008467","article-title":"A clinical scoring system to predict long-term arthralgia in chikungunya disease: a cohort study","volume":"14","author":"Moraes","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2026091410315368900_ref25","first-page":"e72","article-title":"Persistent arthralgia and related risk factors in laboratory-confirmed cases of chikungunya virus infection in Mexico","volume":"41","author":"Murillo-Zamora","year":"2017","journal-title":"Rev Panam Salud Publica"},{"key":"2026091410315368900_ref26","doi-asserted-by":"crossref","first-page":"101618","DOI":"10.1016\/j.tmaid.2020.101618","article-title":"Prevalence of and risk factors for long-term disabilities following chikungunya virus disease: a meta-analysis","volume":"35","author":"Noor","year":"2020","journal-title":"Travel Med Infect 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in autoimmunity","volume":"134","author":"Fairweather","year":"2024","journal-title":"J Clin Invest"},{"key":"2026091410315368900_ref34","doi-asserted-by":"crossref","first-page":"e220271","DOI":"10.1530\/JOE-22-0271","article-title":"Immunology of chronic low-grade inflammation: relationship with metabolic function","volume":"257","author":"Vyver","year":"2023","journal-title":"J Endocrinol"},{"key":"2026091410315368900_ref35","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S2213-8587(23)00154-7","article-title":"Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases","volume":"11","author":"Perakakis","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026091410315368900_ref36","first-page":"189","article-title":"Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses","volume":"11","author":"Chen","year":"2014","journal-title":"Virol J"},{"key":"2026091410315368900_ref37","doi-asserted-by":"crossref","first-page":"620","DOI":"10.23736\/S1973-9087.21.06520-5","article-title":"Resistance exercises improve physical function in chronic chikungunya fever patients: a randomized controlled trial","volume":"57","author":"Neumann","year":"2021","journal-title":"Eur J Phys Rehabil Med"},{"key":"2026091410315368900_ref38","doi-asserted-by":"crossref","first-page":"101672","DOI":"10.1016\/j.eclinm.2022.101672","article-title":"An evaluation of global chikungunya clinical management guidelines: a systematic review","volume":"54","author":"Webb","year":"2022","journal-title":"EClinicalMedicine"},{"key":"2026091410315368900_ref39","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(25)00372-1","article-title":"Chikungunya virus virus-like particle vaccine safety and immunogenicity in adults older than 65 years: a phase 3, randomised, double-blind, placebo-controlled trial","volume":"405","author":"Tindale","year":"2025","journal-title":"Lancet"},{"key":"2026091410315368900_ref40","doi-asserted-by":"crossref","first-page":"958820","DOI":"10.3389\/fimmu.2022.958820","article-title":"Increased platelet activation and platelet-inflammasome engagement during chikungunya infection","volume":"13","author":"Gomes de Azevedo-Quintanilha","year":"2022","journal-title":"Front Immunol"},{"key":"2026091410315368900_ref41","doi-asserted-by":"crossref","first-page":"e0007327","DOI":"10.1371\/journal.pntd.0007327","article-title":"Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): a prospective cohort study","volume":"14","author":"Bertolotti","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"2026091410315368900_ref42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/590003","article-title":"Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on Reunion Island","volume":"47","author":"Borgherini","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2026091410315368900_ref43","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1007\/s10067-025-07737-w","article-title":"Post-chikungunya musculoskeletal symptoms and predictors of chronic inflammatory joint disease, Mato Grosso, Brazil","volume":"44","author":"Brito","year":"2025","journal-title":"Clin Rheumatol"},{"key":"2026091410315368900_ref44","doi-asserted-by":"crossref","first-page":"102726","DOI":"10.1016\/j.tmaid.2024.102726","article-title":"Clinical profile and management of a Spanish single-center retrospective cohort of patients with post-chikungunya associated complications","volume":"60","author":"Calle-Prieto","year":"2024","journal-title":"Travel Med Infect Dis"},{"key":"2026091410315368900_ref45","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/art.40384","article-title":"Frequency of chronic joint pain following chikungunya virus infection: a Colombian cohort study","volume":"70","author":"Chang","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2026091410315368900_ref46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tmaid.2017.11.013","article-title":"Post-chikungunya chronic inflammatory rheumatism: follow-up of cases after 1 year of infection in Tolima","volume":"21","author":"Consuegra-Rodr\u00edguez","year":"2018","journal-title":"Colombia. 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