{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:10:38Z","timestamp":1793761838945,"version":"4.6.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1093\/jtm\/tay116","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T20:48:58Z","timestamp":1542401338000},"source":"Crossref","is-referenced-by-count":33,"title":["Rifamycin SV-MMX\u00ae for treatment of travellers\u2019 diarrhea: equally effective as ciprofloxacin and not associated with the acquisition of multi-drug resistant bacteria"],"prefix":"10.1093","volume":"25","author":[{"given":"Robert","family":"Steffen","sequence":"first","affiliation":[{"name":"Department of Public Health, Epidemiology, Biostatistics and Prevention Institute, WHO Collaborating Centre for Travellers\u2019 Health, University of Zurich, Zurich, Switzerland"},{"name":"Division of Epidemiology, Human Genetics & Environmental Sciences and Center for Infectious Diseases, University of Texas School of Public Health, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Human Genetics & Environmental Sciences and Center for Infectious Diseases, University of Texas School of Public Health, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica L","family":"Gracias Garcia","sequence":"additional","affiliation":[{"name":"Private Clinica, Quetzaltenango, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithi","family":"Araujo","sequence":"additional","affiliation":[{"name":"Medical Department, NUSI Wockhardt Hospital, Cuncolim, Margao, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-0389","authenticated-orcid":false,"given":"Michael","family":"Stiess","sequence":"additional","affiliation":[{"name":"Research and Development, Dr Falk Pharma GmbH, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanju","family":"Nacak","sequence":"additional","affiliation":[{"name":"Research and Development, Dr Falk Pharma GmbH, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Greinwald","sequence":"additional","affiliation":[{"name":"Research and Development, Dr Falk Pharma GmbH, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert L","family":"DuPont","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Human Genetics & Environmental Sciences and Center for Infectious Diseases, University of Texas School of Public Health, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,30]]},"reference":[{"key":"key\n\t\t\t\t2019012510102572300_tay116C1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2014.17006","article-title":"Traveler\u2019s diarrhea: a clinical review","volume":"313","author":"Steffen","year":"2015","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jtm.12179","article-title":"Epidemiology and self-treatment of travelers\u2019 diarrhea in a large, prospective cohort of department of defense beneficiaries","volume":"22","author":"Lalani","year":"2015","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C3","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/taw072","article-title":"Epidemiology of travellers\u2019 diarrhea","volume":"24","author":"Steffen","year":"2017","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C4","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax003","article-title":"Etiology of travellers\u2019 diarrhea","volume":"24","author":"Jiang","year":"2017","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4269\/ajtmh.2009.80.609","article-title":"Global etiology of travelers\u2019 diarrhea: systematic review from 1973 to the present","volume":"80","author":"Shah","year":"2009","journal-title":"Am J Trop Med Hyg"},{"issue":"suppl_1","key":"key\n\t\t\t\t2019012510102572300_tay116C6","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax026","article-title":"Guidelines for the prevention and treatment of travelers\u2019 diarrhea: a graded expert panel report","volume":"24","author":"Riddle","year":"2017","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ajg.2016.126","article-title":"ACG Clinical Guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults","volume":"111","author":"Riddle","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"suppl_1","key":"key\n\t\t\t\t2019012510102572300_tay116C8","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/taw090","article-title":"Resistant pathogens as causes of traveller\u2019s diarrhea globally and impact(s) on treatment failure and recommendations","volume":"24","author":"Tribble","year":"2017","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1473-3099(16)30319-X","article-title":"Import and spread of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study","volume":"17","author":"Arcilla","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tmaid.2017.01.003","article-title":"Fluoroquinolone antibiotic users select fluoroquinolone-resistant ESBL-producing Enterobacteriaceae (ESBL-PE)\u2014data of prospective traveller study","volume":"16","author":"Kantele","year":"2017","journal-title":"Travel Med Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C11","year":"2016"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C12","year":"2016"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1345\/aph.1K347","article-title":"Safety concerns with fluoroquinolones","volume":"41","author":"Mehlhorn","year":"2007","journal-title":"Ann Pharmacother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s40264-013-0089-8","article-title":"Tendon injury and fluoroquinolone use: a systematic review","volume":"36","author":"Stephenson","year":"2013","journal-title":"Drug Saf"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C15","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/cid\/cix693","article-title":"Trial Evaluating Ambulatory Therapy of Travelers\u2019 Diarrhea (TrEAT TD) study: a randomized controlled trial comparing 3 single-dose antibiotic regimens with loperamide","volume":"65","author":"Riddle","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C16","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.4269\/ajtmh.2006.74.1060","article-title":"A randomized, double-blind, multicenter study of rifaximin compared with placebo and with ciprofloxacin in the treatment of travelers\u2019 diarrhea","volume":"74","author":"Taylor","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/cr030112j","article-title":"Rifamycin-mode of action, resistance, and biosynthesis","volume":"105","author":"Floss","year":"2005","journal-title":"Chem Rev"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C18","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2174\/092986710791111170","article-title":"New drug delivery systems in inflammatory bowel disease: MMX and tailored delivery to the gut","volume":"17","author":"Fiorino","year":"2010","journal-title":"Curr Med Chem"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C19","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1128\/AAC.00688-10","article-title":"In vitro activity and single-step mutational analysis of rifamycin SV tested against enteropathogens associated with traveler\u2019s diarrhea and Clostridium difficile","volume":"55","author":"Farrell","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C20","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1128\/AAC.01504-10","article-title":"Systemic absorption of rifamycin SV MMX administered as modified-release tablets in healthy volunteers","volume":"55","author":"Di Stefano","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/jtm.12168","article-title":"Targeting of rifamycin SV to the colon for treatment of travelers\u2019 diarrhea: a randomized, double-blind, placebo-controlled phase 3 study","volume":"21","author":"DuPont","year":"2014","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1086\/338834","article-title":"Prevalence of enteric pathogens among international travelers with diarrhea acquired in Kenya (Mombasa), India (Goa), or Jamaica (Montego Bay)","volume":"185","author":"Jiang","year":"2002","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1128\/JCM.02072-09","article-title":"Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and Mexico","volume":"48","author":"Koo","year":"2010","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C24","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1086\/320756","article-title":"Enteroaggregative Escherichia coli as a major etiologic agent in traveler\u2019s diarrhea in 3 regions of the world","volume":"32","author":"Adachi","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C25","first-page":"1","volume-title":"Performance standards for antimicrobial susceptibility testing: twenty-second informational supplement","author":"Institute CaLS","year":"2012"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/clinids\/10.4.867","article-title":"Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns","volume":"10","author":"Jarlier","year":"1988","journal-title":"Rev Infect Dis"},{"issue":"5","key":"key\n\t\t\t\t2019012510102572300_tay116C27","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax046","article-title":"What proportion of international travellers acquire a travel related illness? A review of the literature","volume":"24","author":"Angelo","year":"2017","journal-title":"J Travel Med"},{"issue":"4","key":"key\n\t\t\t\t2019012510102572300_tay116C28","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax007","article-title":"Global travel patterns: an overview","volume":"24","author":"Glaesser","year":"2017","journal-title":"J Travel Med"},{"issue":"5","key":"key\n\t\t\t\t2019012510102572300_tay116C29","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax056","article-title":"Previous exposure in a high-risk area for travellers\u2019 diarrhoea within the past year is associated with a significant protective effect for travellers\u2019 diarrhoea: a prospective observational cohort study in travellers to South Asia","volume":"24","author":"Kuenzli","year":"2017","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C30","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay099","article-title":"Stand-by antibiotics for travelers\u2019 diarrhea: risks, benefits and research needs","author":"Riddle","year":"2018","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C31","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay081","article-title":"Should travel medicine practitioners prescribe antibiotics for self-treatment of travelers\u2019 diarrhea?","author":"Ericsson","year":"2018","journal-title":"J Travel Med"},{"issue":"6","key":"key\n\t\t\t\t2019012510102572300_tay116C32","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax064","article-title":"Redefining priorities towards graded travel-related infectious disease research","volume":"24","author":"Torresi","year":"2017","journal-title":"J Travel Med"},{"issue":"1","key":"key\n\t\t\t\t2019012510102572300_tay116C33","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay046","article-title":"Travel vaccine preventable diseases\u2014updated logarithmic scale with monthly incidence rates","volume":"25","author":"Steffen","year":"2018","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C34","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1086\/323814","article-title":"Rifaximin versus ciprofloxacin for the treatment of traveler\u2019s diarrhea: a randomized, double-blind clinical trial","volume":"33","author":"DuPont","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C35","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1128\/JCM.26.5.1047-1049.1988","article-title":"Test-of-cure stool cultures for traveler\u2019s diarrhea","volume":"26","author":"Ericsson","year":"1988","journal-title":"J Clin Microbiol"},{"issue":"6","key":"key\n\t\t\t\t2019012510102572300_tay116C36","doi-asserted-by":"crossref","DOI":"10.1177\/030006059702500601","article-title":"Twenty years of experience with intra-articular rifamycin for chronic arthritides","volume":"25","author":"Caruso","year":"1997","journal-title":"J Int Med Res"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ijantimicag.2013.04.020","article-title":"Anti-inflammatory and immunomodulatory activities of rifamycin SV","volume":"42","author":"Rosette","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1023\/A:1027314419843","article-title":"Rifamycins inhibit human neutrophil functions: new derivatives with potential antiinflammatory activity","volume":"21","author":"Spisani","year":"1997","journal-title":"Inflammation"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jac\/dkp178","article-title":"Evolution of antimicrobial resistance in enteroaggregative Escherichia coli and enterotoxigenic Escherichia coli causing traveller\u2019s diarrhoea","volume":"64","author":"Mendez Arancibia","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C40","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1128\/AAC.00739-10","article-title":"In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008","volume":"55","author":"Ouyang-Latimer","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C41","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/cid\/ciu957","article-title":"Antimicrobials increase travelers\u2019 risk of colonization by extended-spectrum betalactamase-producing Enterobacteriaceae","volume":"60","author":"Kantele","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3201\/eid2201.151272","article-title":"Increased risk for ESBL-producing bacteria from co-administration of loperamide and antimicrobial drugs for travelers\u2019 diarrhea","volume":"22","author":"Kantele","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C43","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.3201\/eid1908.130257","article-title":"Extended-spectrum \u03b2-Lactamase\u2013producing Enterobacteriaceae among travelers from the Netherlands","volume":"19","author":"Paltansing","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C44","doi-asserted-by":"crossref","first-page":"731 e1","DOI":"10.1016\/j.cmi.2016.05.003","article-title":"Travel to Asia and traveller\u2019s diarrhoea with antibiotic treatment are independent risk factors for acquiring ciprofloxacin-resistant and extended spectrum beta-lactamase-producing Enterobacteriaceae-a prospective cohort study","volume":"22","author":"Reuland","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C45","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1128\/AAC.00220-10","article-title":"Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum beta-lactamases: a prospective study with Swedish volunteers","volume":"54","author":"Tangden","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"key\n\t\t\t\t2019012510102572300_tay116C46","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tav024","article-title":"High carriage rate of ESBL-producing Enterobacteriaceae at presentation and follow-up among travellers with gastrointestinal complaints returning from India and Southeast Asia","volume":"23","author":"Barreto Miranda","year":"2016","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijantimicag.2014.01.026","article-title":"In vitro activity of rifaximin against clinical isolates of Escherichia coli and other enteropathogenic bacteria isolated from travellers returning to the UK","volume":"43","author":"Hopkins","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/AAC.02163-12","article-title":"Rifaximin resistance in Escherichia coli associated with inflammatory bowel disease correlates with prior rifaximin use, mutations in rpoB, and activity of Phe-Arg-beta-naphthylamide-inhibitable efflux pumps","volume":"57","author":"Kothary","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C49","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/mdr.2011.0010","article-title":"Fitness and molecular mechanisms of resistance to rifaximin in in vitro selected Escherichia coli mutants","volume":"18","author":"Pons","year":"2012","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C50","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1708-8305.2010.00475.x","article-title":"Travelers\u2019 diarrhea in Nepal: an update on the pathogens and antibiotic resistance","volume":"18","author":"Pandey","year":"2011","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t2019012510102572300_tay116C51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s40801-016-0062-9","article-title":"Incidence of sustained ventricular tachycardia in patients with prolonged QTc after the administration of azithromycin: a retrospective study","volume":"3","author":"Sears","year":"2016","journal-title":"Drugs Real World Outcomes"}],"container-title":["Journal of Travel Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jtm\/article-pdf\/25\/1\/tay116\/27502557\/tay116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T06:28:12Z","timestamp":1605421692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jtm\/article\/doi\/10.1093\/jtm\/tay116\/5193265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,30]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jtm\/tay116","relation":{},"ISSN":["1708-8305"],"issn-type":[{"value":"1708-8305","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018]]},"published":{"date-parts":[[2018,1,1]]}}}