{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:38:55Z","timestamp":1770539935656,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kansas State University College of Veterinary Medicine Mentor Clinical"},{"name":"Translational Research Intramural Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effects of a Food and Drug Administration approved non-steroidal anti-inflammatory drug (NSAID) on bovine herpesvirus-1 (BHV-1) shedding in cattle has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The hypothesis of this study was that a single dose of flunixin meglumine would increase the magnitude and duration of viral shedding in calves inoculated with BHV-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve, 6- to 8-week-old, commercial Holstein cross-bred steer calves purchased for research, and BHV-1 polymerase chain reaction (PCR) negative on intake (day-4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized-control study, calves were equally divided into treatment (FM) and control (CON) groups. All calves were inoculated intranasally with approximately 4\u00a0mL of 1\u00a0\u00d7\u00a0105 TCID50 of BHV-1. Nasal swabs for BHV-1 PCR testing were collected every 24\u00a0h after inoculation. Calves in the FM group were treated with 2.2\u00a0mg\/kg of flunixin meglumine intravenously once after the first BHV-1 PCR positive sample. Magnitude and duration of viral shedding between groups was compared, and a P-value of &amp;lt;.05 was considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Least square mean of the total Log10 AUC of the FM group was 6.11 (95% CI: 4.62-7.60) and CON group was 7.49 (95% CI: 6.00-8.98). The FM group\u2019s mean duration from initial to last positive PCR was 7.33\u00a0days\u00a0\u00b1\u00a0SD: 4.41 and the CON group\u2019s mean was 9.5\u00a0days\u00a0\u00b1\u00a0SD: 5.80.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Intranasal inoculation with BHV-1 resulted in a wide range of shedding magnitude and duration. Flunixin meglumine administration in BHV-1 challenged calves did not result in an increase in magnitude or duration of viral shedding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf030","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:02:25Z","timestamp":1768986145000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of a single dose of flunixin meglumine on shedding of inoculated bovine herpesvirus-1 in weaned calves"],"prefix":"10.1093","volume":"40","author":[{"given":"Trey N W","family":"Neyland III","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Kansas State University , Manhattan, KS 66506, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie F","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Kansas State University , Manhattan, KS 66506, \u00a0","place":["United 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