{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:56:25Z","timestamp":1789001785741,"version":"build-2803163510"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"US Food and Drug Administration","doi-asserted-by":"publisher","award":["1UO1FD007049-0"],"award-info":[{"award-number":["1UO1FD007049-0"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tylosin phosphate feed supplementation is the most common method used to control liver abscesses (LAs) in US feedlot cattle, but reducing antimicrobial exposures is critical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>We conducted a 2-phase study, using a randomized controlled trial designed to supplement a Bayesian network meta-analysis (NMA) to test bioequivalence of different durations of tylosin supplementation for the control of A+ LA\u2019s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixteen thousand three hundred sixty-eight feedlot cattle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized controlled trial evaluated 4 treatment groups and was interpreted within an NMA. The treatment groups included no tylosin supplementation (negative control), tylosin supplemented throughout the finishing period (Continuous), withdrawing tylosin 84\u00a0d before harvest (-84WD), or 56\u00a0d before harvest (-56WD). A total of 16 728 animals were randomly allocated in a 1:1:2:2 ratio, respectively. Thirty-two controlled studies with 72 086 enrolled animals, featuring 10 interventions, were incorporated into the NMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Continuous cattle had reduced odds of severe (A+) LAs compared to NC cattle in the randomized trial (odds ratio\u00a0=\u00a00.75; 95% CI, 0.51-1.11). The NMA suggested tylosin use was superior in reducing LAs when compared to untreated cattle. However, early withdrawal did not have equivalent efficacy compared to continuous use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>This investigation successfully merged a systematic review, NMA, and a primary trial to optimize fiscal and animal resources in a major research investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf048","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:49:15Z","timestamp":1769507355000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of tylosin phosphate for liver abscess control in feedlot cattle, by treatment duration: a Bayesian network meta-analysis supported by a randomized trial"],"prefix":"10.1093","volume":"40","author":[{"given":"J Daniel","family":"Young","sequence":"first","affiliation":[{"name":"Department of Agricultural Sciences, West Texas A&M University , Canyon, TX 79015 ,","place":["United States"]},{"name":"VERO Program, Texas A&M University , Canyon, TX 79015 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Morris","sequence":"additional","affiliation":[{"name":"Iowa State University , Veterinary Diagnostic and Production Animal Medicine, Ames, IA 50011 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony C","family":"Bryant","sequence":"additional","affiliation":[{"name":"Five Rivers Cattle Feeding , Johnstown, CO 80534 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Michigan State University , Large Animal Clinical Sciences, East Lansing, MI 48824 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fonseca-Martinez","sequence":"additional","affiliation":[{"name":"Michigan State University , Large Animal Clinical Sciences, East Lansing, MI 48824 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Totton","sequence":"additional","affiliation":[{"name":"Private Consultant , Guelph, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Iowa State University , Veterinary Diagnostic and Production Animal Medicine, Ames, IA 50011 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Weinheimer","sequence":"additional","affiliation":[{"name":"Texas Cattle Feeders Association , Amarillo, TX 79106 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Richeson","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, West Texas A&M University , Canyon, TX 79015 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Morley","sequence":"additional","affiliation":[{"name":"VERO Program, Texas A&M University , Canyon, TX 79015 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026020706121999000_ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2527\/tas2017.0029","article-title":"National Beef Quality Audit-2016: transportation, mobility, and harvest-floor assessments of targeted characteristics that affect quality and value of cattle, carcasses, and by-products","volume":"1","author":"Eastwood","year":"2017","journal-title":"Transl Anim Sci."},{"key":"2026020706121999000_ref2","volume-title":"Canadian Cattleman\u2019s Association.","author":"BCRC","year":"2018"},{"key":"2026020706121999000_ref3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.15232\/aas.2023-02482","article-title":"Relationship of liver abnormalities with carcass performance and value","volume":"40","author":"Grimes","year":"2024","journal-title":"Applied Animal Science."},{"key":"2026020706121999000_ref4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cvfa.2022.08.003","article-title":"Effect of liver abscessation on carcass outcomes","volume":"38","author":"Lawrence","year":"2022","journal-title":"Veterinary Clinics of North America - 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