{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:09:20Z","timestamp":1790057360933,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypersomatotropism (HST) in cats has predominantly been associated with diabetes mellitus (DM) and HST in nondiabetic cats is poorly described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To describe the clinical presentation, clinicopathologic findings, and outcome of nondiabetic cats with presumed HST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-eight client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multi-site retrospective study based on medical records of nondiabetic cats seen at 10 institutions between 2014 and 2024 with presumed HST (elevated serum insulin-like growth factor-1 [IGF-1]\u00a0\u00b1\u00a0clinical signs compatible with acromegaly \u00b1 documented pituitary enlargement). Clinical presentation, diagnostic findings, and survival times were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-eight cats with HST were included. Twenty-six cats were males, and 2 cats were females; mean age was 9.5\u00a0years (\u00b1SD 3.5\u00a0years); mean body weight was 7.1\u00a0kg (\u00b1SD 2.1\u00a0kg). The median serum IGF-1 concentration was 1236\u00a0ng\/mL (range 704-2455\u00a0ng\/mL). Nineteen of 28 cats (68%) had clinical signs possibly related to acromegaly: prognathia inferior (13\/28), weight gain (12\/28), broad facial features (10\/28), abdominal enlargement (10\/28), respiratory stridor (9\/28), polyphagia (9\/28), and signs of neurological disease (3\/28). The most common clinicopathological abnormalities were hyperproteinemia (12\/28), serum creatinine above the reference interval (RI) (10\/28), and urinary specific gravity below the RI (9\/28). Hypertrophic cardiomyopathy phenotype was identified in 8\/17 cases. The most common comorbidity was chronic kidney disease (10\/28). The median survival time after diagnosis was 24\u00a0months (range 1-103\u00a0months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Hypersomatotropism can present without DM and should be considered in cats with signs suggestive of growth hormone excess or a pituitary tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf050","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:02:32Z","timestamp":1768986152000},"source":"Crossref","is-referenced-by-count":2,"title":["Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024)"],"prefix":"10.1093","volume":"40","author":[{"given":"Diego","family":"Miceli","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Endocrinology and Signal Transduction, Institute of Experimental Biology and Medicine 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