{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:55:53Z","timestamp":1769270153412,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In steroid responsive meningitis-arteritis (SRMA), involvement of reticulated platelets is suspected based on the current knowledge of pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To compare reticulated platelets (whole blood) in dogs with SRMA to groups of healthy and diseased dogs. Furthermore, for dogs with SRMA, to investigate if reticulated platelets correlate with total nucleated cell count (TNCC) in cerebrospinal fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Three groups were recruited from the University Hospital for Companion Animals or Anicura Holb\u00e6k Animal Hospital, Denmark; dogs with SRMA (n\u00a0=\u00a010), healthy dogs (n\u00a0=\u00a010), and dogs with signs of gastrointestinal disease and increased C-reactive protein in serum (n\u00a0=\u00a010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study investigated differences in percentages of reticulated platelets and total number of reticulated platelets (#reticPLTs) between included groups using the Kruskal\u2013Wallis test. In dogs with SRMA, TNCC in cerebrospinal fluid and correlation with reticulated platelet variables were investigated with Spearman\u2019s rank correlation coefficient. Statistical significance was defined as P value &amp;lt;\u2009.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A statistically significant difference was found for #reticPLTs between dogs with SRMA (median 4.94\u00a0\u00d7\u00a0109 cells\/L; 95% CI, 3.33-7.32) and dogs with signs of gastrointestinal disease (median 2.56\u00a0\u00d7\u00a0109 cells\/L; 95% CI, 2.02-6.32) (P\u00a0=\u00a0.02). No significant correlation was found between reticulated platelet variables and TNCC in dogs with SRMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>This study highlights potential involvement of reticulated platelets in SRMA pathophysiology. The identified difference in #reticPLT between dogs with SRMA and dogs with signs of inflammatory gastrointestinal disease might suggest differences in inflammatory pathways that are worth investigating in future research of SRMA pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf052","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:02:34Z","timestamp":1768986154000},"source":"Crossref","is-referenced-by-count":0,"title":["Investigation of reticulated platelets in dogs with steroid responsive meningitis-arteritis using ADVIA2120i"],"prefix":"10.1093","volume":"40","author":[{"given":"Pernille Lindholm","family":"Heidemann","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Dyrl\u00e6gevej 16, Frederiksberg C 1870 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Lindeholm","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Dyrl\u00e6gevej 16, Frederiksberg C 1870 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Allpass","sequence":"additional","affiliation":[{"name":"Anicura Holb\u00e6k Animal Hospital , L. 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