{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:40:26Z","timestamp":1785498026177,"version":"3.56.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MiraVista Diagnostics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary coccidioidomycosis (PC) is a common cause of respiratory tract disease in dogs from endemic regions, but evidence-based guidelines for monitoring treatment and determining remission are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Describe temporal changes in clinical signs, antibody serology, and thoracic radiographs in dogs with PC, and evaluate the performance of a treatment monitoring protocol to determine clinical remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-one client-owned dogs with newly diagnosed PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, cohort study. Dogs were examined at diagnosis (T0) and once every 3\u00a0months (T1-T4) until remission or for a maximum of 12\u00a0months. Clinical status was assessed using an owner-completed visual analog scale (VAS) representative of the 24\u00a0hours and 7\u00a0days that preceded the visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 24-hour and 7-day VAS scores increased (ie, clinical signs improved) from T0 (24-hour: mean, 95% confidence interval [CI]; 42.3\u00a0mm, 35.0-50.2; 7-day: 39.6\u00a0mm, 31.9-47.3) to T1 (24-hour, 85.7\u00a0mm, 78.1-93.3, 7-day, 84.4\u00a0mm, 76.8-92.1, P\u00a0&amp;lt;\u00a0.001) with minimal change thereafter. Immunoglobulin G titers decreased from T0 (median, interquartile range [IQR]; 1:16, 1:4-1:32) to T1 (1:2, 1:1-1:8, P\u00a0&amp;lt;\u00a0.001) without significant changes thereafter. Eighty-four percent (26\/31) of dogs achieved remission in a mean of 258.9\u00a0days (SD, 108.9), which occurred at T1 (13%, 4\/31), T2 (23%, 7\/31), T3 (32%, 10\/31), and T4 (16%, 5\/31). Relapse occurred in 15% (4\/26) of dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Most dogs with PC are expected to achieve remission within 6-9\u00a0months of starting antifungal treatment, and relapse is not uncommon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf064","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:44:16Z","timestamp":1770302656000},"source":"Crossref","is-referenced-by-count":1,"title":["A treatment monitoring protocol to determine clinical remission in dogs with pulmonary coccidioidomycosis"],"prefix":"10.1093","volume":"40","author":[{"given":"Jared A","family":"Jaffey","sequence":"first","affiliation":[{"name":"Department of Specialty Medicine, Midwestern University, College of Veterinary Medicine , Glendale, AZ 85308 ,","place":["United 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Glendale, AZ 85308 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Chittick","sequence":"additional","affiliation":[{"name":"Department of Specialty Medicine, Midwestern University, College of Veterinary Medicine , Glendale, AZ 85308 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"2026020706124363100_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00112-19","article-title":"Early events in coccidioidomycosis","volume":"33","author":"Donovan","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"2026020706124363100_ref2","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.2460\/javma.2005.226.1846","article-title":"Incidence of Coccidioides infection among dogs residing in a region in which the organism is endemic","volume":"226","author":"Shubitz","year":"2005","journal-title":"J Am 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