{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:37:15Z","timestamp":1770550635995,"version":"3.49.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity in cats is a complex metabolic condition, and understanding its metabolic processes is essential for gaining new insights into nutrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Investigate the effects of enzymatically-hydrolyzed poultry byproduct meal (EHPM-c) on the serum metabolomic profile of obese cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighteen adult, neutered, obese domestic cats were enrolled in the study. All subjects underwent comprehensive veterinary evaluations to confirm overall health and rule out concurrent systemic diseases, ensuring a homogenous study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cats were randomized into 2 groups and fed for 45\u00a0days with isonutritive diets containing either 30.8% conventional poultry byproduct meal (CPM-c) with 0.0% EHPM-c, or 17.0% CPM-c with 12.0% EHPM-c. After a 30-day diet standardization period, evaluations were performed at baseline (T0) and 45\u00a0days (T45) after consumption of the experimental diets. Metabolic spectra were obtained using nuclear magnetic resonance spectroscopy and analyzed using MetaboAnalyst\u00ae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Principal component analysis did not identify differences in the overall metabolite profiles between the groups, but discriminant analysis identified changes in the intensities of valine, acetate, 1-methylhistidine, and glycerol in the test group after 45\u00a0days. Additionally, pathway analysis indicated a significant effect on propanoate metabolism, ethanol degradation, fatty acid biosynthesis, and glycerolipid metabolism in the test group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>These findings suggest enhanced fat mobilization and improved utilization of branched-chain amino acids, potentially benefiting energy metabolism in obese cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalaf075","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:03:35Z","timestamp":1768986215000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum metabolomics identifies metabolic changes in obese cats fed enzymatically hydrolyzed poultry byproduct meal"],"prefix":"10.1093","volume":"40","author":[{"given":"Leonardo","family":"de Andrade Pr\u00edncipe","sequence":"first","affiliation":[{"name":"Pet Nutrology Research Center, School of Veterinary Medicine and Animal Science, University of Sao Paulo , Pirassununga 13635-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique","family":"Marchi","sequence":"additional","affiliation":[{"name":"Pet Nutrology Research Center, School of Veterinary Medicine and Animal Science, University of Sao Paulo , Pirassununga 13635-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Dantas","family":"Micheletti","sequence":"additional","affiliation":[{"name":"Pet Nutrology Research Center, School of Veterinary Medicine and Animal Science, University of Sao Paulo , Pirassununga 13635-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Marcos Bovetto","family":"de Campos Valim","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo , Pirassununga 13635-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nara Regina Brand\u00e3o","family":"C\u00f4nsolo","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo , Pirassununga 13635-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Silveira","family":"Pedreira","sequence":"additional","affiliation":[{"name":"Nutrition Development Center, Grandfood Industria e Comercio LTDA (Premier Pet) , Dourado 13590-000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Toloi","family":"Jeremias","sequence":"additional","affiliation":[{"name":"Nutrition Development Center, Grandfood Industria e Comercio LTDA (Premier Pet) , Dourado 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