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Fasted and post-prandial blood samples were collected to measure serum insulin and whole blood glucose concentrations, and fasted samples were analyzed for serum cholesterol, triacylglycerol (TAG), nonesterified fatty acid (NEFA), very low-density lipoprotein (VLDL), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) concentrations at the end of each period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No differences were found in serum insulin, glucose, cholesterol, NEFA, TAG, HDL-c, LDL-c, or VLDL concentrations between lean and obese cats (P\u00a0&amp;gt;\u00a0.05) suggesting dyslipidemia was not present in the obese cats. The LP diet resulted in lower post-prandial insulin concentrations compared with the LC and LF diets (P\u00a0=\u00a0.01) which was attributed to lower protein intake with the LP diet. As expected, the LF diet led to lower fasted serum cholesterol and LDL-c concentrations compared with the LP and LC diets (P\u00a0&amp;lt;\u00a0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>These findings document the metabolic flexibility of cats and suggest that dietary macronutrient composition, particularly protein content, plays an important role in modulating insulin responses in adult, otherwise healthy, cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag013","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:59:32Z","timestamp":1771336772000},"source":"Crossref","is-referenced-by-count":1,"title":["Circulating lipid profiles and post-prandial glucose and insulin in response to dietary macronutrient composition in lean and obese cats"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-6926","authenticated-orcid":false,"given":"Hannah","family":"Godfrey","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-2814","authenticated-orcid":false,"given":"\u00c9rico M","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Verton-Shaw","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-4774","authenticated-orcid":false,"given":"Anna Kate","family":"Shoveller","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, Ontario Agricultural College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcia","family":"Kostiuk","sequence":"additional","affiliation":[{"name":"Champion Petfoods Holding Inc., Department of Research, Innovation and Product Development , Morinville, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Kelly","sequence":"additional","affiliation":[{"name":"Champion Petfoods Holding Inc., Department of Research, Innovation and Product Development , Morinville, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0155-9921","authenticated-orcid":false,"given":"Jennifer","family":"Saunders Blades","sequence":"additional","affiliation":[{"name":"Champion Petfoods Holding Inc., Department of Research, Innovation and Product Development , Morinville, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-8866","authenticated-orcid":false,"given":"Adronie","family":"Verbrugghe","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph , Guelph, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"2026021708592757600_ref1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/1746-6148-8-147","article-title":"Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome","volume":"8","author":"Tvarijonaviciute","year":"2012","journal-title":"BMC Vet Res"},{"key":"2026021708592757600_ref2","first-page":"1533","article-title":"Diabetes and insulin resistance associated disorders: disease and the therapy","volume":"83","author":"Chakrabarti","year":"2002","journal-title":"Curr Sci"},{"key":"2026021708592757600_ref3","doi-asserted-by":"publisher","first-page":"258624","DOI":"10.1155\/2012\/258624","article-title":"The carnivore connection hypothesis: revisited","volume":"2012","author":"Brand-Miller","year":"2012","journal-title":"J Obes"},{"key":"2026021708592757600_ref4","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.2337\/dc24-S002","article-title":"2. 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