{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:10:36Z","timestamp":1771870236869,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatitis-associated protein (PAP-1) is synthesized during acute pancreatitis (AP) and chronic enteropathy in people. Serum PAP-1 concentration (PAP-1) has not been measured prospectively in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate whether PAP-1 differentiates suspected AP (sAP) diagnosed by abnormal DGGR-lipase activity from non-pancreatic acute gastrointestinal disease (aGId) diagnosed by normal DGGR-lipase activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-six dogs with sAP, 48 dogs with aGId based on signs of acute gastrointestinal disease, lipase activity &amp;gt;\u2009450\u00a0U\/L (reference interval [RI],17-156\u00a0U\/L) and maximally 20\u00a0U\/L\u00a0&amp;gt;\u00a0RI, respectively. Forty healthy control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective daily assessment included a simplified modified canine activity index (MCAI). PAP-1, lipase activity, C-reactive protein concentration (CRP) were measured daily. PAP-1 assay validation comprised precision, interferences, linearity, and RI establishment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower\/upper PAP-1 quantification limits were 0.2 and 6.0\u00a0\u03bcg\/mL, linearity was excellent (R2 0.999) at high, acceptable (R2 0.966) at low PAP-1 concentrations. Intra-, inter-run precision was \u22645%, \u226422%, PAP-1 remained stable for 15\u00a0days (room temperature), no interferences were found. Duration of hospitalization and clinical disease severity did not differ between groups. At admission, PAP-1 above RI in 50% and 48 % of sAP and aGId dogs, respectively (sAP median, range 1.88\u00a0\u03bcg\/mL, 0.2-6.0 vs. aGId 1.57\u00a0\u03bcg\/mL, 0.2-6.0; RI, &amp;lt;1.9\u00a0\u03bcg\/mL). PAP-1 did not differ significantly between groups irrespective of observation time points. PAP-1 correlated significantly with CRP in sAP (rs\u00a0=\u00a00.623) and aGId (rs\u00a0=\u00a00.483). PAP-1 correlated significantly with lipase activity (rs\u00a0=\u00a00.474) in sAP, with MCAI (rs\u00a0=\u00a00.342) in aGId.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and clinical importance<\/jats:title>\n                    <jats:p>Serum PAP-1 reflects inflammation rather than underlying disease processes, and does not differentiate sAP from aGId.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag015","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:10:44Z","timestamp":1771866644000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum pancreatitis-associated protein 1 concentrations in dogs with acute signs of gastrointestinal disease and normal or abnormal DGGR lipase activity"],"prefix":"10.1093","volume":"40","author":[{"given":"Melanie","family":"Sidler","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Katrin","family":"Helfer-Hungerbuehler","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brugger","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition and Dietetics, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Riond","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Dennler","sequence":"additional","affiliation":[{"name":"Clinic of Diagnostic Imaging, Department of Clinical Services, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Unterer","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H","family":"Kook","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich 8057 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026022312103714900_ref1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/jvim.12334","article-title":"Agreement of serum spec cPL with the 1,2-o-dilauryl-rac-glycero glutaric 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