{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:41:02Z","timestamp":1776786062880,"version":"3.51.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic bronchopneumopathy (EBP) in dogs is an idiopathic disease presumably caused by hypersensitivity to causative allergens that remain unidentified. In humans, allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity to Aspergillus fumigatus in uncontrolled asthma in patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Investigate potential implications of A fumigatus and other ubiquitous antigens (house dust mites, HDMs) in dogs with EBP compared to healthy dogs and dogs with chronic bronchitis (CB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Paired serum and bronchoalveolar lavage fluid (BALF) from dogs with EBP or CB and healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case\u2013control observational study. Quantitative PCR (qPCR) for A fumigatus was performed on BALF and A fumigatus-specific antibodies were investigated using a validated ELISA on serum and BALF. An ELISA also was performed for HDM-specific antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aspergillus fumigatus qPCR was weakly positive in BALF in 2 of 23 EBP dogs and negative in all other dogs. Concentrations of A fumigatus-specific immunoglobulin E (IgE) in serum and BALF were very low and did not differ between groups. Concentrations of A fumigatus-specific serum immunoglobulin G (IgG) were higher in EBP dogs than in CB dogs and healthy dogs (P\u00a0=\u00a0.01) but concentrations in BALF were not different. Concentrations of HDM-specific IgG were higher in both serum and BALF in EBP dogs compared with CB dogs (P\u00a0=\u00a0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Higher concentrations of serum IgG for A fumigatus and HDM observed in EBP dogs might suggest an IgG-dependent disease. Based on our results, EBP is not mediated by A fumigatus-specific IgE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag024","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:32:08Z","timestamp":1773844328000},"source":"Crossref","is-referenced-by-count":0,"title":["Increased serum antibody responses to\n                    <i>Aspergillus fumigatus<\/i>\n                    and house dust mite antigens in dogs with idiopathic eosinophilic bronchopneumopathy"],"prefix":"10.1093","volume":"40","author":[{"given":"Aude Morgane","family":"Canonne","sequence":"first","affiliation":[{"name":"IMRB, INSERM, Univ Paris Est Cr\u00e9teil , Cr\u00e9teil 94010 ,","place":["France"]},{"name":"IMRB, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort , Maisons-Alfort 94700 ,","place":["France"]},{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge , Li\u00e8ge 4000 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