{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:40:52Z","timestamp":1776786052710,"version":"3.51.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calciprotein particles (CPP) are nanoparticles that play an important role in the pathogenesis of chronic kidney disease-mineral and bone disorder (CKD-MBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Identification of plasma CPP and preliminary exploration of the relationships among CPP concentrations, calcification propensity (T50), and CKD-MBD variables in cats with azotemic CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Cats with azotemic CKD (n\u00a0=\u00a052) stabilized on a phosphate-restricted diet (PRD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Total CPP (T-CPP), low-density CPP (L-CPP), and high-density CPP (H-CPP) were measured in heparinized plasma using a fluorescent bisphosphonate (OsteoSense) after gel filtration. Standardized linear regression models evaluated associations among CPP, T50, and CKD-MBD variables. Generalized estimating equations compared preprandial and postprandial CPP concentrations. Calciprotein particle changes (\u0394CPP) between visits were compared between cats with different ionized calcium (iCa) trajectories using independent samples t-test or Mann\u2013Whitney U tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fibroblast growth factor-23 (standardized coefficient [s\u03b2], 0.35; P\u00a0=\u00a0.04) and parathyroid hormones (s\u03b2, \u22120.34; P\u00a0=\u00a0.042) were significantly associated with preprandial T-CPP concentrations in cats fed a PRD, whereas phosphate was significantly associated with postprandial T-CPP (s\u03b2, 0.72; P\u00a0=\u00a0.003) and L-CPP (s\u03b2, 0.75; P\u00a0=\u00a0.003) concentrations before dietary phosphate restriction. \u0394T-CPP was significantly greater in cats with CKD with uptrend iCa compared to those with downtrend iCa after PRD stabilization (14\u2009105\u00a0\u00b1\u00a036\u2009299\u00a0AU vs \u221229\u2009495\u00a0\u00b1\u00a049\u2009664\u00a0AU; P\u00a0=\u00a0.036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Calciprotein particle measurement is possible in cats and adds to the assessment of CKD-MBD, particularly the risk of soft tissue mineralization. The trajectory of iCa after PRD might influence CPP concentrations in cats with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag037","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:00:07Z","timestamp":1773176407000},"source":"Crossref","is-referenced-by-count":0,"title":["Calciprotein particles in cats with naturally occurring chronic kidney disease"],"prefix":"10.1093","volume":"40","author":[{"given":"Pak-Kan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London , London ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kuro-o","sequence":"additional","affiliation":[{"name":"Division of Mineral Metabolism, Center for Molecular Medicine, Jichi Medical University , Shimotsuke, Tochigi 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