{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:40:57Z","timestamp":1776786057636,"version":"3.51.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Tennessee Research Foundation Maturation Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic strategies are needed to treat immune-mediated diseases in dogs. Human intravenous immunoglobulin (hIVIG), approved to treat inflammatory diseases in humans, has been used in dogs with some success in some immune-mediated hematologic and dermatologic disorders. However, cost, supply issues, and safety concerns have limited studies in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Evaluate the feasibility of swine immunoglobulin G (SwIgG) in healthy dogs as a replacement for hIVIG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Three healthy female beagles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Swine IgG purified by column chromatography and injected SC into beagle dogs with or without intradermal injections at predetermined time points. The dogs were observed for up to 3\u00a0weeks with blood collected for clinical chemistry, hematology, and cytokine analysis. Clinical monitoring included heart rate, temperature, and respiratory rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Injection of 1 dose (1\u00a0g\/kg) of SwIgG resulted in vomiting after injection that resolved with treatment; no other clinical signs were observed over the 3-week period. One beagle that received a single dose of 0.2\u00a0g\/kg SwIgG had a reaction and was removed from the second trial. The third beagle received 3 serial doses of 0.5\u00a0g\/kg SwIgG with no adverse reaction throughout the 3-week period. Clinical chemistry in all dogs indicated slight increase in creatine kinase activity, C-reactive protein concentration, and aspartate aminotransferase activity which returned to normal by day 7 postinjection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>It is feasible to use SwIgG in dogs and additional studies to investigate its use as an adjunctive treatment for immune-mediated disorders are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag046","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:45:31Z","timestamp":1774511131000},"source":"Crossref","is-referenced-by-count":0,"title":["Pilot study on the safety of swine immunoglobulin in dogs as a substitute for human intravenous immunoglobulin"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7009-7505","authenticated-orcid":false,"given":"Sophie","family":"Strome","sequence":"first","affiliation":[{"name":"Lake Forest Animal Hospital , Gaithersburg, MD ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4854-7140","authenticated-orcid":false,"given":"Jillian","family":"Smith","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, University of Tennessee , Knoxville, TN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1348-0562","authenticated-orcid":false,"given":"Namita","family":"Sinha","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center , Memphis, TN ,","place":["United 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