{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:40:38Z","timestamp":1776786038870,"version":"3.51.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>C-reactive protein (CRP) concentration in serum or plasma is high in humans during adrenal crisis due to multiple mechanisms, however, the frequency and clinical relevance of high CRP concentrations in dogs with hypoadrenocorticism are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To determine the frequency of high CRP concentrations in serum or plasma of dogs with hypoadrenocorticism. We hypothesized that CRP concentrations are commonly above reference limit in dogs with hypoadrenocorticism with and without inflammatory comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty-one dogs with hypoadrenocorticism presented to 2 referral centers between 2017 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were retrospectively reviewed for dogs diagnosed with and presenting for illness due to hypoadrenocorticism. Dogs were grouped according to identification of a concurrent inflammatory disease at the time of diagnosis, and whether electrolyte abnormalities were present. C-reactive protein concentrations were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-one dogs were included. C-reactive protein concentration in serum or plasma was above 10\u00a0mg\/L in 38 of 51 (75%) cases. Median CRP concentration was 52.5\u00a0mg\/L (range 8-191.4); this was not significantly different between dogs with (n\u00a0=\u00a014) or without (n\u00a0=\u00a037) a known inflammatory comorbidity (54.25 [8.0-191.4] and 44.0 [8-180.8] mg\/L, respectively, P\u00a0=\u00a0.35), or between dogs with (n\u00a0=\u00a032) or without (n\u00a0=\u00a013) electrolyte abnormalities (48.25 [8.0-180.8] and 63.0 [8.0-191.4] mg\/L, respectively, P\u00a0=\u00a0.51).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>High CRP concentrations in serum or plasma were frequently identified in dogs with hypoadrenocorticism, including dogs without recognized inflammatory comorbidities. Hypoadrenocorticism should be considered as a differential diagnosis in cases with high CRP concentrations and vague clinical signs. Extensive investigations for high CRP concentrations in dogs with hypoadrenocorticism might not be necessary without other supporting evidence of an inflammatory comorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag054","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:39:51Z","timestamp":1775313591000},"source":"Crossref","is-referenced-by-count":0,"title":["Frequency of abnormal C-reactive protein concentrations in blood of dogs with hypoadrenocorticism"],"prefix":"10.1093","volume":"40","author":[{"given":"Miranda X","family":"Tong","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Murdoch University , Perth, WA 6150 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiarni L","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Western Australian Veterinary Emergency and Specialty , Perth, WA 6164 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmel T","family":"Mooney","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University College Dublin , Dublin 4, D04 W6F6 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Tebb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Western Australian Veterinary Emergency and Specialty , Perth, WA 6164 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Tan","sequence":"additional","affiliation":[{"name":"Advanced Vetcare Veterinary Centre, Bedok, 488692 ,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrin J","family":"Boyd","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Murdoch University , Perth, WA 6150 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle L","family":"Hosgood","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Murdoch University , Perth, WA 6150 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E","family":"Shiel","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Murdoch University , Perth, WA 6150 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"2026042110462856500_ref1","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"2026042110462856500_ref2","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.3390\/ani12202888","article-title":"C-reactive protein as a diagnostic marker in dogs: a review","volume":"12","author":"Malin","year":"2022","journal-title":"Animals (Basel)"},{"key":"2026042110462856500_ref3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1292\/jvms.70.127","article-title":"C-reactive protein concentration in dogs with various diseases","volume":"70","author":"Nakamura","year":"2008","journal-title":"J Vet Med Sci"},{"key":"2026042110462856500_ref4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/jvim.12262","article-title":"Serum C-reactive protein as a diagnostic biomarker in dogs with bacterial respiratory diseases","volume":"28","author":"Viitanen","year":"2014","journal-title":"J Vet Intern Med"},{"key":"2026042110462856500_ref5","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/j.1476-4431.2009.00462.x","article-title":"Use of C-reactive protein to predict outcome in dogs with systemic inflammatory response syndrome or sepsis","volume":"19","author":"Gebhardt","year":"2009","journal-title":"J Vet Emerg Crit Care"},{"key":"2026042110462856500_ref6","volume-title":"Canine C-Reactive Protein - 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