{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:40:35Z","timestamp":1776786035353,"version":"3.51.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholecystectomy is well described for gallbladder mucocele management, but its role in other gallbladder diseases is less well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Characterize and compare dogs undergoing cholecystectomy for mature gallbladder mucocele (M-GBM) versus \u201cother gallbladder disease\u201d (non-M-GBM). A secondary exploratory aim was to compare surgical complication and 10 to 14-day mortality rates between cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 256 dogs undergoing cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study (2018-2025). Dogs were assigned to M-GBM or non-M-GBM groups based on radiologist review of stored ultrasonographic images. Clinical, biochemical, histopathologic, and outcome variables were compared. Survival was evaluated using Kaplan\u2013Meier curves and restricted mean survival time estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-nine dogs were classified as M-GBM and 187 as non-M-GBM. The M-GBM dogs were significantly older (11.0\u00a0\u00b1\u00a02.8 vs 8.7\u00a0\u00b1\u00a03.1\u00a0years; P\u00a0&amp;lt;\u00a0.001) and had higher white blood cell (13.8\u00a0\u00b1\u00a07.3 vs 10.0\u00a0\u00b1\u00a04.5\u00a0k\/\u03bcL; P\u00a0&amp;lt;\u00a0.001), and neutrophil counts (10.5\u00a0\u00b1\u00a06.2 vs 7.3\u00a0\u00b1\u00a03.9\u00a0k\/\u03bcL; P\u00a0&amp;lt;\u00a0.001), and ALT (148; interquartile range [IQR]: 55.2-402 vs 78; IQR: 42.5-278.5\u00a0U\/L; P\u00a0&amp;lt;\u00a0.001) and ALP activities (446; IQR: 148-1860 vs 178; IQR: 59.5-786.8\u00a0U\/L; P\u00a0&amp;lt;\u00a0.001). Fourteen-day mortality was significantly lower in the non-M-GBM cohort (3.2 vs 8.7%; P\u00a0=\u00a0.04). Post-surgical clinical improvement occurred in 83.7% of non-M-GBM dogs. Concurrent pancreatic and intestinal abnormalities were common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Cholecystectomy was safe, associated with owner-perceived clinical improvement, and carried a lower short-term mortality rate in non-M-GBM dogs compared with M-GBM dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag071","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:02:15Z","timestamp":1776355335000},"source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and outcomes of dogs undergoing cholecystectomy for diseases other than a mature gallbladder mucocele: a retrospective cohort study"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-2307","authenticated-orcid":false,"given":"Harry","family":"Cridge","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University , East Lansing, MI 48824 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizette","family":"Cotto","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University , East Lansing, MI 48824 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarod","family":"Williams","sequence":"additional","affiliation":[{"name":"Ozark Veterinary Specialty Care , Springdale, AR 72762 ,","place":["United 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