{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:40:18Z","timestamp":1777952418576,"version":"3.51.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IVC Evidensia Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 2-year-old Boxer dog was examined for a 2-week history of progressive, painful right-lateralized paraparesis. Magnetic resonance imaging showed a focal ovoid mass with suspected intramedullary, or less likely, intradural location at the level of L3 vertebral body. Based on the imaging features, neoplasia, and specifically, a nephroblastoma, was suspected. Surgical excision found a difficult to excise mass with indistinct borders. The dog showed marked deterioration postoperatively and was euthanized 3\u00a0days later due to suspected myelomalacia. Histopathology and immunohistochemistry of the biopsy revealed that the spinal cord was replaced by a poorly organized proliferation of cells that consisted of both neuronal and glial components, embedded within an edematous neuropil. Immunohistochemistry of the lesion showed positivity for neuronal and astrocytic markers. These findings were consistent with a ganglioglioma, a rare neoplasm in dogs.<\/jats:p>","DOI":"10.1093\/jvimsj\/aalag081","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:28:53Z","timestamp":1777897733000},"source":"Crossref","is-referenced-by-count":0,"title":["Lumbar spinal cord ganglioglioma in a 2-year-old Boxer dog"],"prefix":"10.1093","volume":"40","author":[{"given":"Julia","family":"Hauer","sequence":"first","affiliation":[{"name":"Neurology Service, Tierklinik Hofheim - IVC Evidensia GmbH , Katharina-Kemmler-Strasse 7, Hofheim am Taunus 65719 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Polidori","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences, Vetsuisse Faculty, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Oevermann","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences, Vetsuisse Faculty, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Einwaller","sequence":"additional","affiliation":[{"name":"Neurology Service, Tierklinik Hofheim - IVC Evidensia GmbH , Katharina-Kemmler-Strasse 7, Hofheim am Taunus 65719 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schmohl","sequence":"additional","affiliation":[{"name":"Neurology Service, Tierklinik Hofheim - IVC Evidensia GmbH , Katharina-Kemmler-Strasse 7, Hofheim am Taunus 65719 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Wessmann","sequence":"additional","affiliation":[{"name":"Neurology Service, Tierklinik Hofheim - IVC Evidensia GmbH , Katharina-Kemmler-Strasse 7, Hofheim am Taunus 65719 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"2026050408284884100_ref1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477015","volume-title":"Tumors of the Central Nervous System","author":"Burger","year":"2007"},{"key":"2026050408284884100_ref2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/BF00294510","article-title":"Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases","volume":"88","author":"Wolf","year":"1994","journal-title":"Acta Neuropathol"},{"key":"2026050408284884100_ref3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40478-018-0551-z","article-title":"The genetic landscape of ganglioglioma","volume":"6","author":"Pekmezci","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"2026050408284884100_ref4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/030098588702400215","article-title":"Ganglioglioma of the spinal cord in a calf","volume":"24","author":"Roth","year":"1987","journal-title":"Vet Pathol"},{"key":"2026050408284884100_ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0021-9975(05)80106-9","article-title":"An immunohistochemical study of peripheral neuroblastoma, ganglioneuroblastoma, anaplastic ganglioglioma, schwannoma, and neurofibroma in cattle","volume":"111","author":"Omi","year":"1994","journal-title":"J Comp Pathol"},{"key":"2026050408284884100_ref6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3389\/fvets.2019.00356","article-title":"Ganglioglioma in the right cerebrothalamus in a 7-year-old quarter horse cross gelding","volume":"6","author":"Easton-Jones","year":"2019","journal-title":"Front Vet"},{"key":"2026050408284884100_ref7","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1177\/104063871002200623","article-title":"Desmoplastic ganglioglioma of the spinal cord in a western European hedgehog (Erinaceus europaeus)","volume":"22","author":"Ulrich","year":"2010","journal-title":"J Vet Diagn Invest"},{"key":"2026050408284884100_ref8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/vru.13426","article-title":"Clinical presentation and magnetic resonance imaging findings of a spinal cord ganglioglioma in a 7.5-year-old, male, neutered German shepherd dog","volume":"65","author":"Swan","year":"2024","journal-title":"Vet Radiol Ultrasound"},{"key":"2026050408284884100_ref9","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/vetsci9100514","article-title":"First case of a cerebrocortical ganglioglioma in a dog","volume":"9","author":"Mart\u00edn","year":"2022","journal-title":"Vet Sci"},{"key":"2026050408284884100_ref10","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1177\/030098586900600605","article-title":"Intraocular ganglioglioma in a dog","volume":"6","author":"Saunders","year":"1996","journal-title":"Pathol Vet"},{"key":"2026050408284884100_ref11","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1177\/0300985819829530","article-title":"Hyperadrenocorticism caused by a pituitary ganglioglioma in a dog","volume":"56","author":"Ishino","year":"2019","journal-title":"Vet Pathol"},{"key":"2026050408284884100_ref12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1292\/jvms.65.113","article-title":"Ganglioglioma in the thalamus of a puppy","volume":"65","author":"Uchida","year":"2003","journal-title":"J Vet Med Sci"},{"key":"2026050408284884100_ref13","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/jvim.12182","article-title":"Intramedullary spinal cord neoplasia in 53 dogs (1990-2010): distribution, clinico- pathologic characteristics, and clinical behavior","volume":"27","author":"Pancotto","year":"2013","journal-title":"J Vet Intern Med"},{"key":"2026050408284884100_ref14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1532-950X.2010.00789.x","article-title":"Canine spinal nephroblastoma: long-term outcomes associated with treatment of 10 cases (1996\u20132009)","volume":"40","author":"Liebel","year":"2011","journal-title":"Vet Surg"},{"key":"2026050408284884100_ref15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1740-8261.2003.tb00503.x","article-title":"Imaging of a spinal nephroblastoma in a dog","volume":"44","author":"McConnell","year":"2003","journal-title":"Vet Radiol Ultrasound"},{"key":"2026050408284884100_ref16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0899-7071(91)90157-Q","article-title":"MRI features of spinal ganglioglioma","volume":"15","author":"Cheung","year":"1991","journal-title":"Clin Imaging"},{"key":"2026050408284884100_ref17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1023\/B:NEON.0000024747.66993.26","article-title":"Spinal cord gangliogliomas: a review of 56 patients","volume":"68","author":"Jallo","year":"2004","journal-title":"J Neurooncol"},{"key":"2026050408284884100_ref18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/2156-7514.166355","article-title":"Ganglioglioma of the spinal cord","volume":"5","author":"Oppenheimer","year":"2015","journal-title":"J Clin Imaging Sci"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/3\/aalag081\/68206422\/aalag081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/3\/aalag081\/68206422\/aalag081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:28:54Z","timestamp":1777897734000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/doi\/10.1093\/jvimsj\/aalag081\/8666798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jvimsj\/aalag081","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,5]]},"article-number":"aalag081"}}