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Gait evaluation showed high lifting of both pelvic limbs resulting in a hopping movement in the rear end; the right pelvic limb was kept lifted, making the dog trot on the 3 other limbs. Both thoracic limbs were lifted higher than normal. Complete blood count and serum biochemistry analysis including creatine kinase activity were normal. Electrophysiological examination showed no abnormalities. Muscle biopsy samples collected at a later stage of the disease showed no abnormalities. A homozygous frameshift variant in SETX (senataxin) was identified and is predicted to truncate about 85% of the protein. The SETX variant adds a new gene variant to the list affecting Jack Russell Terriers with gait abnormalities.<\/jats:p>","DOI":"10.1093\/jvimsj\/aalag085","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:16:16Z","timestamp":1778343376000},"source":"Crossref","is-referenced-by-count":0,"title":["Progressive abnormal gait in an adult Jack Russell Terrier with a homozygous frameshift variant in\n                    <i>SETX<\/i>\n                    (senataxin)"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-1359","authenticated-orcid":false,"given":"G Diane","family":"Shelton","sequence":"first","affiliation":[{"name":"Department of Pathology, University of California San Diego , La Jolla, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie F M","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Small Animal Department, Ghent University , Salisburylaan 133, Merelbeke 9820 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Van Ham","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Small Animal Department, Ghent University , Salisburylaan 133, Merelbeke 9820 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven G","family":"Friedenberg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonah N","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling T","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California San Diego , La Jolla, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie M","family":"Minor","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"2026050912160559000_ref1","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1111\/jvim.16108","article-title":"International veterinary canine dyskinesia task force ECVN consensus statement: terminology and classification","volume":"35","author":"Cerda-Gonzalez","year":"2021","journal-title":"J Vet Intern 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